Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

Promotor: J.G.E.M. Fraaije, Co-Promotor: A. Kros

The thesis describes the use of electron paramagnetic resonance (EPR) spectroscopy, in continuous wave and pulse modes, to address the interaction of α-Synuclein (αS) with membranes and the aggregation of αS.

Multicellular giant algae Chara species have been widely used in physiological studies for decades.

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

The plant hormone auxin plays a central role in the growth and development of plants. Auxin acts in a concentration dependent manner and polar cell-to-cell transport of this hormone determines its distribution in the tissues of plants. This polar auxin transport is mediated by several families of auxin…

Promotor: A. Kros

Promotor: M. Ubbink, Co-promotor: G. Siegal

The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.

Alexander Kros and co-workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled-coil lipopeptides inserted into the membrane of cells and in the bilayer of lipid-coated…

The skin barrier function is provided by the stratum corneum (SC). The lipids in the SC are composed of three lipid classes: ceramides (CERs), cholesterol (CHOL) and free fatty acids (FFAs) which form two crystalline lamellar structures. In the present study, we investigate the effect of CER chain length…

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

The European Research Council (ERC) has awarded chemist Dr Alexander Kros a Starting Independent Researcher Grant of 1.4 million euro. He will be using the grant to study how molecules penetrate the natural barrier of a cell membrane. If his research is successful, it will in time bring about a revolution…

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

Task of the Computer Committee is to give advice, possibly unsolicited, on ICT matters to the Management Team of LIACS. This includes advice on ICT related policies of the faculty and university, procurement of computer and other machinery, and system administration.

PhD candidates carry out a programme of independent research and additional (limited) course work, culminating in production of a PhD thesis in typically 4 years.

Promotor: J. A. Bouwstra

Beowulf clusters looking for new frontiers.

The two-year master’s programme in Computer Science at Leiden University offers seven specialisations ranging from AI to Bioinformatics and Data Science. The programme combines excellent theoretical teaching with possibilities for applied work with industrial relevance.

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

In this work we describe three methods to improve the performance of Quantum Field Theory calculations.

Source: International Journal of Cosmetic Science, Volume 37, Number 1, pp. 158-158 (2015) ISBN: 0142-5463

The effectiveness of the skin barrier underlies the outer layer of the skin: the stratum corneum (SC). However, in several skin diseases this barrier is impaired. In two inflammatory skin diseases, atopic eczema and Netherton syndrome, an increased level of monounsaturated fatty acids (MUFAs) has been…

Promotor: Prof.dr. S. Haring

A high resolution, three dimensional view of a molecule provides detailed information that help elucidate its function: by knowing the exact arrangement of atoms in a molecule, we can understand disease, develop drugs to combat them and improve technology.

The worldwide race to the quantum computer is in full swing. This computer can take on computing tasks that we can only dream of today, such as finding proteins that can be used as medicines in seconds flat. Leiden physicists have discovered how the Majorana particle can be used as a building block…

LIACS is partner in the project 'Stereotyping in Computer Science.' The project is a collaboration between multiple universities and the Dutch national expert organization on girls/women and science/technology (VHTO), which will investigate the stereotypes that children hold about computer scientist…

Natural Computing investigates algorithms and phenonema based on nature to create better and new computer science innovations.

Our goal is to develop usable, practical and meaningful Brain-Computer Interfaces to diagnose, restore, repair and enhance functions of the impaired brain.

We are becoming ever more dependent on automation systems in our daily lives. Computer Science is more than programming; you integrate maths and logic into the development of systems and solutions that can be applied in all fields - from business to healthcare.

The Computer Support group provides dedicated support for the computing infrastructure of Leiden Observatory

Met de bachelorspecialisatie Informatica & Economie aan de Universiteit Leiden leer je waardevolle inzichten in de economie te combineren met (programmeer)vaardigheden en kennis uit de informatica.

Promotor: S.J. Edixhoven, L.D.J. Taelman

The master's specialisation Bioinformatics at Leiden University focuses on research, development and application of computational tools and approaches for expanding the use of biological, medical, behavioral and health data.

The master’s specialisation Computer Science and Education at Leiden University prepares students to teach the subject of biology to secondary school students. The programme comprises a one-year Computer Science component, followed by an education component in the second year.

Research in this group, headed by Gerard van Westen, focusses on computational methods integrated in different parts of the drug discovery process. More specifically, topics include innovative treatments for cancer, selectivity modeling, translational research, allosteric modulation, drug resistance…

The master's specialisation Data Science: Computer Science at Leiden University provides students thorough knowledge and understanding of statistical and computational aspects of data analysis, including their application in databases, advances in data mining, networks, pattern recognition, and deep…

High Performance Computing previously the domain of theoretical scientists and computer and software developers is becoming ever more important as a research tool in many research areas. A University facility, providing serious computational capabilities, combined with easy and flexible local access,…

This dissertation investigates Extended Lexical Units (ELUs), elements that are bigger than just one word and which are stored in the Lexicon.

Leiden Institute of Advanced Computer Science (LIACS)

Promotor: Roeland M.H. Merks

This thesis is a collection of theoretical works aiming at adjusting quantum algorithms to the hardware of quantum computers.

The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.

The goal of the MODOMA-project is to create a computer model of language acquisition.

LUMC Technology Focus Area (TFA) Data Analytics is een samenwerkingsverband van verschillende onderzoeksgroepen in het LUMC die nieuwe kwantitatieve en computationele methodologie ontwikkelen voor biomedisch en klinisch onderzoek.

The Computer Systems, Imagery & media (CSI) program performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems. Focus is furthermore on methods and techniques for the analysis…

The first book ever on information-theoretically secure multiparty computation

The master’s specialisation Computer Science and Science Communication and Society at Leiden University bridges the gap between experts and the public by combining high quality research in computer science with extensive training in science communication.

The quantum computer is on its way, but is society ready for it? Quantum computers have a reputation of being difficult to grasp because of their complexity. This limits society’s ability to envision future applications creating a gap between society and quantum computers. A consortium of 14 knowledge…