Multiple Sclerosis, Parkinson’s and Alzheimer’s disease are the most common neurodegenerative disorders. Unfortunately, no effective treatments are currently available to halt the progression of these neuroinflammatory diseases [1].

Cell adhesion signaling

Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

Promotor: H.P. Spaink, A.H. Meijer Co-promotor: R. Marin-Juez

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotores: A.H. Meijer, H.P. Spaink

An international research team consisting of Katharina Riebel as leading PI and two international collaborators were awarded a Human Frontier Science Program grant for their proposal ‘Seeing voices’: the role of multimodal cues in vocal learning.

Promotor: Prof.dr. P. Hooykaas, Co-promotor: Dr. R. Offringa

The Minor Computational Approaches to Disease, Signaling and Drug Targets (CADSDT) is focused on fundamental scientific research required for discovery of new drug targets and development of new drugs.

In previous studies at our laboratory it was demonstrated that drug exposure of HepG2 cells can lead to an altered TNFα-induced NF-κB oscillatory phenotype, concurrent with a synergistically increased sensitivity for TNFα-induced apoptosis.

Bacteria are highly complex and diverse organisms that have adapted to survive in ecological niches ranging from the most extreme to the most heterogeneous environments.

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

This thesis focuses on the role of chemokine receptors CXCR3 and CCR2 in the inflammatory process and infection control using the zebrafish model.

This project is funded by the Dutch Cancer Society. The project will be part of an ongoing research line aimed at identifying mechanisms of cancer therapy resistance and metastasis. In this project, it will be investigated how the Grainyhead family of transcription factors controls therapy response…

The cannabinoid CB2 receptor (CB2R) represents a promising therapeutic target for various forms of tissue injury and inflammatory diseases. Although numerous compounds have been developed and widely used to target CB2R, their selectivity, molecular mode of action and pharmacokinetic properties have…

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

Handbook of Signal Processing Systems is organized in four parts. The first part motivates representative applications that drive and apply state-of-the art methods for design and implementation of signal processing systems; the second part discusses architectures for implementing these applications;…

Source: Mol Psychiatry (2015)

Promotor: B. van de Water

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

On November 1st, Min Liu succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Min on this great result.

This thesis considers multi-prover commitment schemes whose security is based on restrictions on the communication between the provers.

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

The PID-directed shift in PIN polarity has been broadly accepted as one of the essential mechanisms for the regulation of auxin transport polarity.

IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

Promotor: A.H. Meijer, Co-promotor: B.E. Snaar-Jagalska

Physicists have studied the astrophysical neutrino signal as reported by the IceCube collaboration from a different angle with their ANTARES detector. The Milky Way centre was an obvious prime suspect to be a source, but this hypothesis is now only closer to debunked than confirmed. Publication in Physical…

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

How do animals choose their partners? The answer is simple: it’s all about quality. While humans tend to wear clothes that happen to be in fashion, animals do nothing without a reason. Behind beautiful plumage or a deafening roar is only one message: I am in great shape. The evolutionary courtship displays…

Behavioural biologist Wouter Halfwerk has been awarded a 2-year outgoing Rubicon-grant from NWO. He will be working at the Smithsonian Tropical Research Institute with bats and frogs to understand the evolution of multimodal communication.

It is important for students to meet alumni of the program, to see what jobs they have.

Promotor: P.M. Brakefield

Efficiently responding to others’ emotions has great survival value, especially for social species, such as primates, who establish close, long-term bonds with group members. The closest living relatives to humans are the chimpanzee and the bonobo. Studying these species, and comparing them on the exact…

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Heart failure is a major health care problem with high mortality.

Galaxy intrinsic alignments induce a major astrophysical contamination to weak gravitational lensing measurements and need to be modelled and mitigated when extracting cosmological information from such measurements.

Promotor: Prof.dr. J. Memelink

Promotor: A. Achúcarro Co-promotor: A. Boyarsky

An overview of the research at the Cancer Dug Target Discovery group.