1415 search results for “mathematical modeling” in the Public website

Mathematical modelling of advanced herbal extraction
Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Mathematical modelling of adverse outcome pathways
In this project, we aim to develop mathematical models to mechanistically and quantitatively predict the dynamics of cellular stress pathway activation and its relation with toxic effects when cells are exposed to various toxicants.

Bioactivity based quality control for Chinese herbal medicine
Can we establish a new quality control system for herbal medicines that is based on bioactivity rather than a few abundant chemicals?

Prediction of spatialtemporal brain drug distribution with a novel mathematical model
A novel mathematical model describes spatialtemporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Mathematical modeling of cellular stress pathways for mechanistic understanding of chemicalinduced liver injury
Cellular stress response pathways are activated upon exposure to chemicals and help organisms deal with various molecular dangers (e.g. oxidative stress). When these pathways become hyperactivated an adverse response takes place and cells die, which may lead to organismlevel toxicity such as druginduced…

Quantitative biology of polar auxin transport and plant development
The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

Ruben Huele
Wiskunde en Natuurwetenschappen

Mathematical model predicts drug concentration in the brain
Do medicines arrive in the right amount at the right spot in our brain? By making a model that depicts our brain in small 'brain blocks', PhD student Esmée Vendel tries to find an answer to this question. Her new, mathematical model predicts the concentration of medicines in the brain over time and…

A mathematical model for a more diverse workforce
Many organisations have a biased workforce, even though diversity has so many advantages. Australian and Dutch researchers, including Leiden psychologist Romy van der Lee, have developed a solution based on a mathematical model. They published their findings in PLoS One on 28 July.

Mathematical analysis of systems pharmacology models
Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

Multiscale mathematical biology of cellextracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Mathematical model helps to explain the formation of spine and ribs
Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.

Anja RuetenBudde
Wiskunde en Natuurwetenschappen

Mathematicsbased strategies for repairing tumour blood vessels
How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic wasteproducts and matrixdegrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

Xinru Li
Wiskunde en Natuurwetenschappen

Leiden hosts seventh Survival Analysis for Junior Researchers conference
Next April, Leiden will host the seventh annual international Survival Analysis for Junior Researchers conference (SAfJR2018). This threeday event is aimed at careeryoung statisticians with an interest in the application and development of timetoevent analysis and related topics. The conference…

Prediction of spatialtemporal brain drug distribution with a novel mathematical model
PhD Defence

Predicting medicine behaviour in the brain: from crystal ball to mathematical model
Lecture

Predict Human CNS PK/PD: Preclinical Experiments and Advanced Mathematical Modelling
Lecture

LCN2 Seminar: Mathematical Modeling of Embryonic Development: The Intra and Extracellular Networks that Coordinate Collective Cell Behavior
Lecture

Sanne Willems
Wiskunde en Natuurwetenschappen

Preparing MFDEs for the Modelling World
Classical mathematical models treat space and time as a continuum, while it is sometimes more useful to regard it as granular. Hupkes is studying what this means for a number of important patterns that are often found in computer calculations and in nature.

Nightingale Colloquium presents Cynthia Liem
Lecture

Florence Nightingale Colloquium presents Odette Scharenborg
Lecture, Lunch included

Florence Nightingale Colloquium presents Max Welling
Lecture

Florence Nightingale Colloquium presents Peter Grünwald  webinar
Lecture
 Florence Nightingale Colloquium

Jan van Haaren brings Football Analysis to the Florence Nightingale Colloquium
Lecture, including drinks and nibbles at the FooBar

CANCELLED: Florence Nightingale Colloquium presents Max Welling
Lecture, Lunch included

Florence Nightingale Colloquium presents Johannes SchmidtHieber
Lecture, Lunch included

Florence Nightingale Colloquium presents Tjeerd van Staa
Lecture

Nightingale Colloquium presents Veronika Cheplygina
Lecture

Florence Nightingale Colloquium presents Marta Fiocco
Lecture

Anisotropy in cell mechanics
Mechanical interactions between cells and their environment play an important role in many biological processes.

Mathematical Institute
Mathematics forms the basis of many innovations in technology, the service industry and science, such as data analysis and coding, artificial intelligence, weather or climate change modelling or understanding molecular processes. The researchers from the Mathematical Institute (MI) are constantly developing…

Mathematics as weapon against desertification
PhD student Robbin Bastiaansen applies mathematics to get insight in practical problems. By comparing mathematical models with developments in existing ecosystems, he hopes to demystify the process of desertification. His research has been published in Proceedings of the National Academy of Sciences…

PhD candidates in Mathematical Statistics
Science, Mathematical Institute (MI)

Theoryenriched practical knowledge in mathematics teacher education
This study looks at the question of how and at what level students in primary teacher education can integrate theory and practice, and how the organisation of their learning environment, focusing especially on mathematics and pedagogy, can contribute to that.

Predictive pharmacology
The aim of this research area is to be able to predict human drug response on the basis of mathematical models that are developed using preclinical experiments and prior knowledge.

Spatial (3D) CNS drug distribution in vivo
Another research line is the development of a spatial CNS drug distribution model, by ultimately including the 3dimensional anatomical organization of the CNS.

Plant BioDynamics Laboratory
The Plant BioDynamics Lab (PBDL) is a laboratory dedicated to experiments designed to develop and validate quantitative mathematical models of dynamical processes in biology. The principal objective of developing these models is to make quantitative predictions about these processes.

Student projects
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Mathematics cluster STAR tenure track
Perform cuttingedge research in the area of the STAR mathematics cluster.

Indefinite integration through recognition based heuristic search
Towards a framework that integrates contentbased and processbased accounts of mathematical thinking

Mathematics
PhD candidates carry out a programme of independent research, leading to a PhD thesis in typically 4 years.

Stefan Semrau Lab
We study cellfate decisionmaking using embryonic stem cells as a model system. Stem cells integrate a large number of cues to direct their development into a great variety of cell types.

Prediction of human gut (colon cancer) target site concentrations and PKPD relationships
The advanced insights obtained for the CNS PBPK model development are currently used to develop advanced mathematical models for drug distribution prediction in other body tissues protected by barriers, such as the gut. The gut PBPK model will be linked to drug effects for treatment of colon cancer.

Sander Hille
The effectiveness of antibiotics and the transport of the plant hormone auxin: both can be described using mathematical models. Sander Hille is a mathematician who works at the cutting edge of biology and mathematics. His interdisciplinary research is both fundamental and applied. When working on fundamental…

Bayesian Statistics in Infinite Dimensions: Targeting Priors by Mathematical Analysis
Novel methods for understanding key aspects that are essential to the future of Bayesian inference for high or infinitedimensional models and data.

Personalised medicine for multiple outcomes: methods and application
The main objective of this thesis was to develop clinically relevant survival models for patients with highgrade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.