Promotor: Roeland M.H. Merks

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Promotores: Prof. Dr. Th.J.C. van Berkel, Prof. Dr. M. van Eck

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The objective is to develop in vitro antigen degradation assays in order to mimic the fate of the antigen in vivo.

Projects within the theme ‘Computational Biology’ aim to employ mathematical or computational dynamical modelling approaches to discover novel concepts that are important for drug development.

What are the principles of genome folding and dynamics in bacteria?

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.

Chemotherapy that does nothing until you irradiate it with light. Sylvestre Bonnet receives a Vici grant of 1.5 million euros for the development of this treatment. The Leiden chemist wants to build a new molecule to fight tumours that are at the time still difficult to treat.

Getting personal

Searching for ways to delay the need for a transplant and trying to build kidneys to order.

More and more medicines are becoming available that target a tumour’s specific traits. The use of chemotherapy is continually undergoing improvement.

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The LUMC Flow Cytometry Core Facility accommodates all research and diagnostic flow cytometry equipment of the LUMC.

GitLab is a single application for the entire software development lifecycle. We use the Leiden University gitlab services

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Physics and Engineering Approaches to Biomedicine and Pharmacology

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The Green algae Chara as model system for intra and inter cellular transport processes.

Science, Leiden Academic Centre for Drug Research (LACDR)

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

Worldwide resurgence of pertussis necessitates the need for improvement of pertussis vaccines and vaccination strategies.

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Exploiting metabolic vulnerabilities to identify anticancer compounds in zebrafish synthetic lethality screens.

Can we develop new enzymes and cell factories to upgrade current enzyme cocktails towards complete degradation of biomass?

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The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

For more information regarding ongoing research projects, please contact Prof. Johan Kuiper.

We investigate reaction systems, a novel computational model gleaned from the biochemical reactions taking place in living cells and information processing in nature.

How can the transport of molecules in living cells help to target medicines at exactly the right place?

The imaging group focuses on bio-imaging, image analysis and visualization.

The LUMC iPSC Hotel offers the generation of research grade human induced pluripotent stem cells (hiPSCs) from different tissue sources using state of the art reprogramming techniques.

With an ageing population it is becoming increasingly important to find means to repair cells, tissue and organs through regenerative medicine.

There are several training oportunities within the cell observatory

An overview of our infrastructure at the SPP division:

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Is there a sufficiently large market for drug screening and testing in Zebrafish larvae using membrane fusion?

Ecotox is located in an ambitious surrounding at the Leiden University. It is an initiative of both institutes Institute of Environmental Sciences (CML) and Institute of Biology Leiden (IBL).

Vaccination via the skin or the mucosae

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

Promotores: J. Jonkers, K.E. de Visser

Promotor: G.F.A. Kersten, W. Jiskoot, Co-promotor: B. Metz