562 search results for “mass spectrometry” in the Public website
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volume regime in metabolomics with capillary electrophoresis-mass spectrometry
Ramautar
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers
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Enabling volume-restricted metabolomics using next-generation microscale analytical tools
Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.
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BioMedical Metabolomics Facility Leiden
The BioMedical Metabolomics Facility Leiden (BMFL) offers a highly structured environment for advanced metabolomics studies. BMFL builds on fully validated, state-of-the-art platforms that each cover a part of the human metabolism and together span the complete human metabolome.
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken
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Analytical chemistry and biochemistry of glycosphingolipids: new developments and insights
Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…
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Towards automated identification of metabolites using mass spectral trees
Promotor: Prof.dr. T. Hankemeier, Co-promotor: Dr. Theo Reijmers
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Sheathless capillary electrophoresis-mass spectrometry as a new approach for analyzing the polar metabolome
Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.
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Rawi RamautarWiskunde en Natuurwetenschappen
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Capillary Electrophoresis-Mass Spectrometry for Metabolomics
In the field of metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In order to highlight the unique features of CE-MS for metabolomics studies, Dr. Rawi Ramautar…
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Interview with Rawi Ramautar at ASMS Conference 2015
Live from the ASMS Conference 2015 in Saint Louis: Baljit Ubhi, our Metabolomics Specialist, has a coffee with Rawi Ramautar, Assistant Professor at the Leiden Academic Center for Drug Research.
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New insights into Neandertal knowledge from the mass-spectrometry analysis of plastic containers
The analysis of protein residues extracted from the storage containers of circa 50,000 year old bone-tools reveals Neandertal strategic selection of bovid ribs to make some of their “lissoirs”.
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Systems pharmacology of the endocannabinoid system
In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Genomics driven metabolomics novel strategies for the discovery and identification of secondary metabolites
Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Young Hae ChoiWiskunde en Natuurwetenschappen
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Mass spectrometry based protein profiling
PhD Defence
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Decomposing tears in order to detect Dry Eye Disease
By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…
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A fatty solution for eczema
Pharmacologist Walter Boiten developed a new method to determine the amount of lipids in a person's skin. With this method he tested the effects of a new cream he developed for eczema patients. The first results are promising. Boiten defends his dissertation on 15 January.
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Mass spectrometry based protein profiling
PhD Defence
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Statistical Methods for Mass Spectrometry-based Clinical Proteomics
PhD Defence
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Clinical Glycomics of Antibodies by Mass Spectrometry
PhD Defence
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Lab-on-a-tissue: Optimization of On-Tissue Chemistry for Improved Mass Spectrometry Imaging
PhD Defence
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Biomarker Discovery in High Grade Sarcomas by Mass Spectrometry Imaging
PhD Defence
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Data analysis for mass spectrometry imaging: methods and applications
PhD Defence
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Key publications
Key publications of the Biomedical Microscale Analytics group.
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Facilities
Our facilities cover:
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Joachim Kopka
PhD at the Max Planck Institute of Molecular Plant Physiology, Golm – Germany
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David Overy
Dr. at Agriculture and AgriFood Canada, Ottawa Research & Development Center - Canada
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Environmental and metabolomic study of antibiotic production by actinomycetes
Promotor: Prof.dr. G.P. van Wezel
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Development of novel metabolomics and systems pharmacology methods
We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).
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Teris van Beek
Dr. at the Department of organic chemistry, Wageningen University - the Nederlands
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Systems pharmacology of the endocannabinoid system
What are the functions of the endocannabinoid system?
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The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition
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Young Hae Choi
Associate professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands
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Rob van der Heijden
PhD at Leiden University and Bruker - the Netherlands
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
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Biomedical Microscale Analytics
The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…
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Screening of animal venoms for antimicrobial compounds
Can animal venoms yield novel antimicrobial peptides?
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Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS
Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…
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Bernd Schneider
Dr. at Max Planck Institute for chemical Ecology, Jena - Germany
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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Transvac2
TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…
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Research schools in chemistry
The Leiden Institute of Chemistry actively participates in several national research schools for MSc and PhD students. These schools are consortia that stimulate collaboration between research groups of the different participating Dutch universities. The research schools also offer advanced training…
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity
The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.