209 search results for “mass spectrometry” in the Public website
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Quantification in untargeted mass spectrometry-based metabolomics
Promotor: Prof.dr. T. Hankemeier, Co-promotor: T.H. Reijmers
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High-throughput profiling of small molecules using mass spectrometry
Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken
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Automated de novo metabolite identification with mass spectrometry and cheminformatics
Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier
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Polymers in the Liver: Metabolism and Regulation
Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…
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Sheathless capillary electrophoresis-mass spectrometry as a new approach for analyzing the polar metabolome
Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.
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Capillary Electrophoresis-Mass Spectrometry for Metabolomics
In the field of metabolomics, capillary electrophoresis-mass spectrometry (CE-MS) has become a very useful analytical technique for the profiling of highly polar and charged metabolites in biological samples. In order to highlight the unique features of CE-MS for metabolomics studies, Dr. Rawi Ramautar…
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Virus-host metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Allosteric modulation by sodium ions and amilorides of G protein- coupled receptors
Promotor: A.P. IJzerman
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Allosteric modulation by sodium ions and amilorides of G protein-coupled receptors
Promotor: A.P. IJzerman
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Lab-on-a-tissue: Optimization of On-Tissue Chemistry for Improved Mass Spectrometry Imaging
PhD Defence
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Antimicrobial & Anticancer Compounds
Actinomycetes produce a plethora of bioactive natural products, including two thirds of all antibiotics used in the clinic, and many other medically important molecules such as those with anticancer, antifungal or immunosuppressant activity. We seek to unravel the regulatory networks that control the…
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The Palaeoproteomic Identification of Pleistocene Hominin Skeletal Remains:
Towards a Biological Understanding of the Middle to Upper Palaeolithic Transition
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Development of Comprehensive and High-throughput metabolomics techniques
A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…
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Intercellular Skin Barrier Lipid Composition and Organization in Netherton Syndrome Patients
Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…
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Relative quantification of proteasome activity by activity-based protein profiling and LC-MS/MS
Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…
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Highly sensitive analysis using 3D cell culture model
A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…
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Metabolic Characterization of Marine Sponge
Which metabolites of sponge are influenced by individual environmental or biological factors?
- Tuning the Catalytic Activity of Oxide-Supported Nanoparticles via Plasma-Assisted Synthesis
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The distribution of stellar mass in galaxy clusters over cosmic time
Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: Dr. H.Hoekstra
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The End of our Third Decade (volume II)
Papers written on the occasion of the 30th anniversary of the institute of Prehistory, Volume II.
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Research
The current projects of the Molecular Physiology group focus on kinases and proteins of the endocannabinoid system.
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Mass Torts in Europe
In recent years, the issue of mass tort litigation and the fair and efficient settlement and adjudication of mass torts has drawn increasing attention in academic discourse, legal practice and policy debates.
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5th LCDS meeting: Electron Microscopy and Data Science
Conference
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Publications
Here you can find our most recent research publications
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Feedback from deeply embedded low- and high-mass protostars. Surveying hot molecular gas with Herschel
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg
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Paving the path between low- and high-mass star formation: dynamics probed by Herschel far-infrared spectroscopy
Promotor: Prof.dr. E.F. van Dishoeck, Prof.dr. F.F.S. van der Tak (RUG)
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The way you move: ceramic chronology building through the materialized bodily gestures of manufacturing practices
Lecture, Archaeological Forum
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The Great Collapse
Promotor: Prof.dr. S.F. Portegies Zwart
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Chemical Biology lecture - Human Norovirus: The winding road to entry inhibition
Lecture
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Entertainment and enlightenment for the masses: reality television in China
In the controlled, censored, and taboo-ridden media landscape of communist China, one would not expect seeing a television show featuring real people having actual conflicts. Yet reality programmes about conflict mediation are mushrooming in the People’s Republic. Both the public and the authorities…
- Lecture: 'Pervasive Punishment: Making sense of 'mass supervision’
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One step closer to preventing mass death of roosters
The Dutch biotech start-up In Ovo is the first company to develop a large-scale solution for determining the sex of a chick while it is still in the egg. This fast and cheap technique can be applied mechanically at hatcheries, which was not possible before.
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Shadow Libraries: The Politics of Mass Digitization
Lecture
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Buddhism For the Masses: the History and Future of a Tibetan Storytelling Tradition
Lecture
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'Putting Bashir on trial would be a boost for the International Criminal Court'
Who should try the fallen Sudanese president Bashir? The International Criminal Court (ICC) in The Hague wants to put the former dictator on trial for war crimes, crimes against humanity and genocide in Darfur, but the Sudanese military is refusing to hand him over and wants to try him in their own…
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Rethinking the Role of Ideology in Genocide, Atrocities and Mass Killing
Lecture
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The Connection Between Mass and Light in Galaxy Clusters
PhD Defence
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Interview session: "Looking for the Missing: Mass Graves, Disappearances and Justice in Mexico"
Lecture, Interview session
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StepTalk: Mass Starvation: The History and Future of Famine
Debate, StepTalks
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Unveiling dark structures with accurate weak lensing
Improvements of weak gravitational lensing shape measurements are presented and some used for data analysis.
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Small scale kinematics of massive star-forming cores
Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde
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The interplay between stars, gas and dust in faint star-forming galaxies
When observing star-forming galaxies, we are not only seeing stellar light, but we also see how this interacts with galactic gas and dust. This thesis contains studies of the stellar, nebular and dust properties of low mass star-forming galaxies.
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Behavioral implications of Neandertal energetics
Recent studies of Neandertal body mass and skin surface indicate raised energetic requirements in this lineage compared to anatomically modern humans.
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Club Power
Club power is a muscle-strengthening group session using dumb-bells with special weights. You determine the weight yourself. All exercises are done to fun and lively music.
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Causing a stir: Radiative and mechanical feedback in starburst galaxies
Promotores: Prof.dr. F.P. Israel, Prof.dr. P.P. van der Werf
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Alexey Boiarsky Group
Boyarsky is on a quest to unravel the nature of one of the most mysterious phenomena in the Universe. The cosmos appears to consist for the larger part out of mass we cannot see. We have no idea where it comes from. Physicists call this ‘dark matter’. Sterile neutrinos are candidate building blocks…
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About the Research School
The Research School for Medieval Studies aims to enhance the quality of scholarly training and research within the field of Medieval Studies in the Netherlands and Flanders. The school is a joint venture of six Dutch and three Flemish Universities. (Groningen, Leiden, Utrecht, Amsterdam, VU University…
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The excavation of the Paardenmarkt Alkmaar
In June-August 2010 large scale excavations were executed on the cemetery belonging to the monastery, an area now termed the Paardenmarkt, by Hollandia Archeologen in cooperation with Leiden University. During the course of nine weeks, the students from the former minor Human Osteoarchaeology excavated…
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Education
The department of Business Studies facilitates business study education to students of the Leiden Law School as well as the students of other faculties of Leiden University.
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Pressure groups
Where did the new generation of antislavery activists get their inspiration to organize in large-scale pressure groups?