805 search results for “lysosomal storage disorder” in the Public website
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Implementing carbon capture, utilisation and storage (CCUS) in Society
Lecture, Webinar
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A computational study of structural and excitonic properties of chlorosomes
The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…
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Growth and Transport properties of (Rare Earth)TiO3 / SrTiO3 interfaces
This thesis presents the results of a study on the interfaces of insulating oxides with and without the insertion of a magnetic layer.
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LEF grant for Semiha Aydin to pilot social anxiety treatment
Semiha Aydin is one of the three first-generation researchers who received a grant from the Leiden Empowerment Fund to stimulate their scientific career.
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Stress, Obesity and Mood Disorders
PhD Defence
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Biologics Formulation
The Biologics Formulation Group is led by Prof. Wim Jiskoot. A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals…
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Functional analysis of Dof transcription factors controlling heading date and PPDK gene expression in rice
Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang
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Our facilities
In support of the research and education, the Leiden Institute of Advanced Computer Science (LIACS) has a Research and Education laboratory at its disposal. Within this environment, we can offer machines that go beyond normal office automisation and production.
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Computational facilities
Beowulf clusters looking for new frontiers.
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Fundamental Research in Energy & Sustainability
Twenty years from now, the world population is estimated to be around 9 billion people (now 7.8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables, water and energy.…
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Invasive plant species, models for evolutionary change
Which traits did change due to the invasion process of plants and how do these traits contribute to the invasiveness of such species. What is the role of carbohydrate accumulation? What is the function of carbohydrate accumulation in plants? Is genetic variation depleted in invasive species under se…
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Programme structure
The research master's specialisation Developmental Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.
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Kinetics for drug discovery – The first step towards an improved drug discovery paradigm
Supervisor: Indira Nederpelt
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Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
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Alice in Wonderland-syndrome
FSW Professor Jan Dirk Blom has written a book on Alice in Wonderland syndrome. This is the first scientific book on this rare disorder, which was first described in 1955 by the British psychiatrist John Todd. Todd was inspired by the famous book by Lewis Carroll, in which Alice experiences all kinds…
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Effects of noninvasive vagus nerve stimulation on perseverative cognition
Can excessive worrying be reduced via stimulation of the vagus nerve?
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ERC Synergy Grant to unlock sugar codes for health and a sustainable society
Hermen Overkleeft and his colleagues Gideon Davies (University of York) and Carme Rovira (University of Barcelona) will receive a 9.1 million euros Synergy Grant from the European Research Council. Together, they will form the Carbocentre Synergy team for research into enzymes that work on glycans:…
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Self-regulation in boys with oppositional defiant disorder and conduct disorder
PhD Defence
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mechanisms of social-emotional dysfunction in autism spectrum disorder and conduct disorder
PhD Defence
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Novel chemical tools for target validation in neuroinflammation
In what way can new tools and techniques be used to develop drug candidates for the treatment of neurological disorders?
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Workshop: Endophenotypes of Social Anxiety Disorder
Conference
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Sexual responses can be learned and unlearned
Undesirable associations with sex can be unlearned, but return if the circumstances change. They must therefore be unlearned in different situations. The drug D-cycloserine may help here. These are the findings of psychologist Mirte Brom.
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Centralized Biobanking Facility
The centralized LUMC biobank department helps to implement rules and regulations regarding informed consent, collection, storage and distribution of biomaterials and data for biobanking.
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Light and Electron Microscopy Facility
The aim of this facility is to accelerate biomedical research by providing access to advanced light and electron microscopy and by sharing expertise about sample preparation, imaging modalities, data storage and image analysis.
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About us
All living creatures have to cope with environmental demands and threats that challenge their physical or emotional homeostasis.
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The role of zebrafish (Danio rerio) larvae in developing new drug candidates for treating anxiety, from natural sources
Can zebrafish larvae be used as a behavioural model for screening natural products as potential neurotropic drugs?
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Neurodevelopmental risks in young children with an extra X or Y chromosome
This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.
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Electrocatalytic CO2 reduction toward liquid fuels : on heterogeneous electrocatalysts and heterogenized molecular catalysts
With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.
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The effect of the chain length distribution of free fatty acids on the mixing properties of stratum corneum model membranes
The stratum corneum (SC) plays a fundamental role in the barrier function of the skin. The SC consists of corneocytes embedded in a lipid matrix.
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Energy & Sustainability
Twenty years from now, the world population is estimated to be around 8.7 billion people, compared to the current 7.3 billion. In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables,…
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Solid Bioneedle-Delivered Influenza Vaccines Are Highly Thermostable and Induce Both Humoral and Cellular Immune Responses
The potential of bioneedles to deliver influenza vaccines was investigated.
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Statistical physics and information theory for systems with local constraints
Systems with local constraints is a new finding in recent researches on complex systems. The heterogeneous spatial interactions and the temporal dependencies among those numerous units make it difficult to describe by traditional statistical physics.
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Looking back at the Lorentz Workshop
“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”
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Translational Neuroscience
Within the LUMC medical research profile Translational Neuroscience innovative multidisciplinary research is performed on a number of severe disorders of the brain, nerves and muscles.
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The power of positive peers for socially anxious youth
Can positive peer feedback break the cycle of negative self-relevant cognitive processes and reduce self-reported anxiety in early adolescents?
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Personality disorders and insecure attachment among adolescents
PhD Defence
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Research
At the Sport Data Center, five research themes are explored.
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Sustainable demolition of the Faculty of Science building
The demolition of the high-rise building is ready. The remaining debris are removed and the area is cleared. For the demolition, the University applied the BREEAM evaluation method at the level of ‘Excellent’, which means that the demolition operations were carbon neutral and did not cause any form…
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Cool little kids
Effectiveness of an early intervention program for anxiety-prone toddlers in the Netherlands
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Clinical epidemiology of commonly occurring anxiety disorders
PhD Defence
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Michel Orrit and Hermen Overkleeft members KNAW
The Royal Netherlands Academy of Arts and Sciences (KNAW) selects prominent researchers as members based on their scientific achievements. On September 17th, the KNAW will install 21 new members, including Leiden physicist Michel Orrit and chemist Hermen Overkleeft.
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Presentations and Lectures
Members of our research team give different types of presentations and lectures.
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
Glycosidases are important enzymes in the turnover of polysaccharides and glycoconjugates, and are involved in a range of human pathologies including genetic disorders such as Gaucher and Pompe disease, but also in various cancers.
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Systems pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Self-regulation in boys with ODD/CD
Understanding individual differences in self-regulation in boys with ODD/CD on the level of brain, cognition and behavior
- Martina Huber Lab (EPR Group)
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Research
Research in the group Clinical Neurodevelopmental Studies is focused on understanding and influencing developmental mechanisms in children and adolescents, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.
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Past research
Read about the impact of past research