1692 search results for “long residence time” in the Public website
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Small changes for long term impact: optimization of structure kinetic properties: a case of CCR2 antagonists
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Receptor Residence Time
Research question
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When structure-affinity relationships meet structure-kinetics relationships: 3-((Inden-1-yl)amino)-1-isopropyl-cyclopentane-1-carboxamides as
Source: Eur J Med Chem (2015)
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Visa and residence permit
Do you need a visa or residence permit for your stay in the Netherlands? What will it cost and how can you apply? Find out how and when you can request a student visa or residence permit via Leiden University.
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Visa & Residence Permit
If you are going to study in the Netherlands as a foreign student you may need an entry visa (MVV) and/or a residence permit (VVR). Whether you need a visa and/or a residence permit depends on your purpose of stay, the length of your stay and your nationality.
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Visa and residence permit
Whether you need a visa and a residence permit depends on your purpose of stay, the length of your stay and your nationality. If you are going to study in the Netherlands as a foreign student you may need a visa (MVV) and/or a residence permit (VVR).
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Residence Life Programme
Leiden University's Residence Life Programme aims to help international students living in university housing in Leiden, Oegstgeest, and The Hague.
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Residence in Tax Treaties
On Thursday 1 December 2016 at 13.45 hrs, Francisco Sepulveda Ramirez will defend his doctoral thesis ‘Residence in Tax Treaties' at the Academy Building of Leiden University. Supervisor is Professor F.A. Engelen.
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Drug-target residence time: a case for the adenosine A1 and A2A receptors
Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Feiteng Long
Faculteit der Sociale Wetenschappen
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Visa, residence and work permit
If you wish to come to the Netherlands, there are certain immigration procedures you need to follow. Leiden University can apply for a visa and residence permit on your behalf.
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Visa, residence and work permit
If you wish to come to the Netherlands, there are certain immigration procedures you need to follow. Leiden University can apply for a visa and residence permit on your behalf.
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Long Island, Antigua
Long Island, an islet of Antigua in the northern Lesser Antilles forms the major source for flint in the Lesser Antilles. A survey by Hofman, Hoogland and van Gijn in 1989 has indicated the presence of various raw material sources. Test-excavations at the major flintknapping site of Flinty Bay show…
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Of Love and Longing
Diede Farhosh-van Loon defended her thesis on 18 October 2016
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Agonists for the Adenosine A1 Receptor with Tunable Residence Time. A Case for Nonribose 4-Amino-6-aryl-5-cyano-2-thiopyrimidines
Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)
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Everyday justice and security provision for displaced and residents in Bukavu, DR Congo
How does the presence of internally displaced people impact on the justice and security concerns of longer-term residents in host communities, and to what extent do residents have different concerns than displaced?
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the Liverpool care pathway for the dying patient in nursing home residents
The Liverpool care pathway for the dying patient (LCP) is a multidisciplinary tool developed for the dying phase for use in palliative care settings. The literature reports divergent experiences with its application in a nursing home setting related to its implementation and staff competencies. The…
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Long term dynamics of stochastic evolution equations
Promotor: S.M. Verduyn Lunel, Co-promotor: O. van Gaans
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present and future: colonial visions and experience in Asia in the residencies
Reproducing past, present and future: colonial visions and experience in Asia in the residencies
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Less government, but who is thinking long term?
On the 18th of November the article: 'Minder overheid, maar wie denkt er na over de lange termijn? (translation from Dutch: 'Less government, but who is thinking long term?') written by prof. dr. Frits M. van der Meer was posted on Mejudice: 'an independent forum for discussions aiming to stimulate…
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Organisation of settlement space and residence rules among the Taino, the indigenous people of the Caribbean encountered by Columbus
This research combines archaeological, archaeometric and ethnohistorical research to study the organisation of settlement space and residence rules among the Taino Indians during the Late Ceramic Age (AD 1000-1492).
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Liposome-based synthetic long peptide vaccines for cancer immunotherapy
Promotores: Wim Jiskoot; Ferry Ossendorp
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The parabolic Anderson model and long-range percolation
Promotor: Prof.dr. F. den Hollander
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Residence in Tax Treaties
On Thursday 1 December 2016 at 13.45 hrs, Francisco Sepulveda Ramirez will defend his doctoral thesis ‘Residence in Tax Treaties' at the Academy Building of Leiden University. Supervisor is Professor F.A. Engelen.
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China’s long march to national rejuvenation: toward a Neo-Imperial order in East Asia?
In tracing the deeper historical roots of what Xi Jinping contemporarily frames as a “Chinese dream” of “wealth and power,” the article discerns key actors, events, and organizing principles in a long process toward restoring China’s deemed rightful place in the regional system.
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Role of epigenetics in long-term health effects of early life stress
Can epigenetic changes explain associations between early life stress and health outcomes?
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Plan B for particle physics: finding long lived particles at CERN
This thesis discusses the discovery potential of Intensity Frontier experiments.
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In vivo fluorescence imaging of IgG1 aggregates after subcutaneous and intravenous injection in mice
PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.
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Intracellular allosteric modulators for human CC chemokine receptors
Supervisor: Natalia Ortiz Zacarías
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The Long Arab Conquest of Central Asia: Urban Change in Merv, Paikent, Balkh and Samarkand (651-821)
This PhD research aims to trace the impact of the Arab conquest, both immediate and long-term, on the material and social organization of Central Asia from 651 to 821 through an “urban change” perspective in four cities: Merv, Paikent, Balkh and Samarkand.
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Transitioning From Military Interventions to Long-Term Counter-Terrorism Policy
These three repors are part of a research project that assesses how military interventions can best prepare the ground for an effective long-term counter-terrorism policy. Three different cases have been studied, and they have each provided the input for the policy relevant recommendations that are…
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Transitioning from Military Interventions to Long-Term Counter-Terrorism Policy
In December 2014, Leiden University’s Institute of Security and Global Affairs with the Australian National University’s Asia-Pacific College of Diplomacy and the International Centre for Counter-Terrorism, commenced a research project to assess how (temporary) military interventions can best prepare…
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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The ins and outs of ligand binding to CCR2
Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman
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Co-damages of environmental policies related to climate change and long-range transboundary air pollution
Using the principles of Industrial Ecology in Environmental Policy making in two cases: transition to a hydrogen economy and chlorinated compounds.
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New History of Fishes. A long-term approach to fishes in science and culture, 1550-1880
From 1550 onwards, a great interest in the natural world developed across Europe. This interest was not only stimulated by a growing knowledge of local flora and fauna, but also by the import of numerous exotic animal and plant species. Think, for instance, of researches and collectors like Gessner…
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Affinity and kinetics study of anthranilic acids as HCA2 receptor agonists
Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.
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Binding kinetics
A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…
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Lipids: Localization of Ceramide and Fatty Acid in the Unit Cell of the Long Periodicity Phase
The lipid matrix of the skin's stratum corneum plays a key role in the barrier function, which protects the body from desiccation. The lipids that make up this matrix consist of ceramides, cholesterol, and free fatty acids, and can form two coexisting crystalline lamellar phases: the long periodicity…
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analysis of different dimensions of the desistance process among long-term prisoners in the Netherlands
On 5 September 2019, Jennifer Doekhie defended her thesis 'Dimensions of desistance: A qualitative longitudinal analysis of different dimensions of the desistance process among long-term prisoners in the Netherlands'. The doctoral research was supervised by Prof. P. Nieuwbeerta.
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Why don't drugs make it to the market?
How can we extend the drug residence time to combat diseases more effectively?
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ARTificial Intelligence Lab offers residency at Leiden Observatory
The European ARTificial Intelligence Lab is now offering artists working with Artificial Intelligence the chance for a residency at the Leiden Observatory and the Ars Electronica Futurelab. Entries are possible until 22 July 2020
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Residents and researchers explore plastic and psychology in the city
This year will see the start of not one but two citizen science projects in Leiden and The Hague. This is the outcome of a large survey among residents and researchers in both university cities. The Citizen Science Lab will help the winners implement their ideas, with support from the University and…
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Thought in East Central Europe Volume I, Negotiating Modernity in the 'Long Nineteenth Century'
A History of Modern Political Thought in East Central Europe is a two-volume project, authored by an international team of researchers, and offering the first-ever synthetic overview of the history of modern political thought in East Central Europe.
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Structure-kinetics relationships of Capadenoson derivatives as adenosine A1 receptor agonists
Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)
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Presenting the NVIC (long version)
Please have a look at the long version of our promo video
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Gabriel Inzaurralde: ‘Literature lets you live four times as long'
As a young boy, Gabriel Inzaurralde, lecturer and researcher in Latin American studies, wanted nothing more than to become a writer. He still writes and passes on lessons from Latin American literature and culture to his students. 'My lectures are a constant attempt to reopen closed minds.'
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The Role of Target Binding Kinetics in Drug Discovery
Source: ChemMedChem (2015)
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Kinetics for Drug Discovery: a Case for the Adenosine A3 receptor
Supervisor: Lizi Xia
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Live long and healthy
Leiden University will be 444 years old this year and is still very much alive and kicking. But how can we humans grow old healthily? Hanno Pijl at LUMC is the grand master of lifestyle medicine. He explains how we can all benefit from a sensible - but still enjoyable - lifestyle.