Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Animal models suggest that the chemokine ligand 2/CC-chemokine receptor 2 (CCL2/CCR2) axis plays an important role in the development of inflammatory diseases. However, CCR2 antagonists have failed in clinical trials because of a lack of efficacy.

Source: Eur J Med Chem (2015)

Research question

Promotor: Prof.dr. A.P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.

This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.

Supervisor: Natalia Ortiz Zacarías

A tantalizing concept that has emerged in our recent research is binding kinetics. An important parameter is residence time (RT), a direct reflection of how long a drug stays bound to its target. This parameter is of crucial importance, because drug action lasts only as long as the receptor-ligand complex…

Supervisor: Lizi Xia

How can we extend the drug residence time to combat diseases more effectively?

Marjolein Soethoudt was awarded the Unilever Research Prize 2013 for the University of Leiden. The prize was bestowed upon her because of her thesis about her 9-months Master’s internship that she performed in the department from September 2011 until July 2012, in combination with her other study re…

In this research group, headed by Laura Heitman, novel receptor concepts in drug discovery are studied, aiming to increase the effectivity of medicines. Many drugs act via so-called G protein-coupled receptors (GPCRs) and therefore our research is mainly focused on understanding and improving drug-receptor…

The receptor nomenclature committee of IUPHAR, the International Union of Pharmacology, has several subgroups. Among these are a few that our division is involved in, those for adenosine, nicotinic acid, and GnRH receptors.

Do you need a visa or residence permit for your stay in the Netherlands? What will it cost and how can you apply? Find out how and when you can request a student visa or residence permit via Leiden University.

On Thursday 1 December 2016 at 13.45 hrs, Francisco Sepulveda Ramirez will defend his doctoral thesis ‘Residence in Tax Treaties' at the Academy Building of Leiden University. Supervisor is Professor F.A. Engelen.

Here you can find our most recent research publications

If you wish to come to the Netherlands, there are certain immigration procedures you need to follow. Leiden University can apply for a visa and residence permit on your behalf.

Leiden University's Residence Life Programme aims to help international students living in university housing in Leiden, Oegstgeest, and The Hague.

If you wish to come to the Netherlands, there are certain immigration procedures you need to follow. Leiden University can apply for a visa and residence permit on your behalf.

If you are going to study in the Netherlands as a foreign student you may need an entry visa (MVV) and/or a residence permit (VVR). Whether you need a visa and/or a residence permit depends on your purpose of stay, the length of your stay and your nationality.

Source: J Med Chem, Volume 57, Issue 8, pp. 3213-22 (2014)

How does the presence of internally displaced people impact on the justice and security concerns of longer-term residents in host communities, and to what extent do residents have different concerns than displaced?

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

Structure-affinity relationship (SAR) and structure-kinetics relationship (SKR) studies were combined to investigate a series of biphenyl anthranilic acid agonists for the HCA2 receptor.

Not taking into account the saturation of drug targets can lead to wrong conclusions about the duration of a drug's action. This is what former PhD candidate Wilbert de Witte writes together with the Leiden professors of pharmacology Meindert Danhof, Piet van der Graaf, and Liesbeth de Lange in Nature…

Source: ChemMedChem (2015)

Reproducing past, present and future: colonial visions and experience in Asia in the residencies

On Thursday 1 December 2016 at 13.45 hrs, Francisco Sepulveda Ramirez will defend his doctoral thesis ‘Residence in Tax Treaties' at the Academy Building of Leiden University. Supervisor is Professor F.A. Engelen.

This research combines archaeological, archaeometric and ethnohistorical research to study the organisation of settlement space and residence rules among the Taino Indians during the Late Ceramic Age (AD 1000-1492).

Subproject of "Differences that make all the difference. Gender, migration and vulnerability (migration to the Netherlands 1945-2005)"

Diede Farhosh-van Loon defended her thesis on 18 October 2016

Long Island, an islet of Antigua in the northern Lesser Antilles forms the major source for flint in the Lesser Antilles. A survey by Hofman, Hoogland and van Gijn in 1989 has indicated the presence of various raw material sources. Test-excavations at the major flintknapping site of Flinty Bay show…

The cultural sector, shut down by the corona pandemic, must urgently look for new ways to generate income.

As a young boy, Gabriel Inzaurralde, lecturer and researcher in Latin American studies, wanted nothing more than to become a writer. He still writes and passes on lessons from Latin American literature and culture to his students. 'My lectures are a constant attempt to reopen closed minds.'

Activities of Tony Roe, Catalina Vicens, Magda Pucci, Hans Kalliwoda, Gary Schultz, Eleni Kamma, and Danne Ojeda

The European ARTificial Intelligence Lab is now offering artists working with Artificial Intelligence the chance for a residency at the Leiden Observatory and the Ars Electronica Futurelab. Entries are possible until 22 July 2020

The Indigenous Calendars of Mexico and Guatemala

Supervisor: Indira Nederpelt

Leiden University celebrated its 444th anniversary with a historical procession on 8 February. It celebrated this year’s Dies Natalis in time-honoured fashion with a ceremony in the Pieterskerk, but broke with tradition by sending professors out to primary schools.

Ferdinand Harmsen (49) is an ICT and Education Coordinator. He helps study programmes that want to use ICT to improve their education. He has been working with IT all his life, although it wasn't his initial calling: 'It turned out to be a very nice instrument to do what really fascinates me'.

Author Bibi Dumon Tak will be the new writer-in-residence at Leiden University from autumn 2020.

Novelist and essayist Karin Amatmoekrim will be writer-in-residence at Leiden University in autumn 2019. She will be the 35th writer-in-residence at the University.

Systems are called real-time systems, if the correctness of the system does not only depend on the correctness of the system output but also on whether the output is delivered on time.

From May to November 2017 the Van Vollenhoven Institute will carry out a research project, funded by NWO/WOTRO, on ‘Everyday justice and security provision for displaced and residents in Bukavu, DR Congo’.

Promotor: Prof.dr. F. den Hollander

1) How natural cycles and activities are interconnected for building the time in one community? 2) What perceptions of Ñuu Dzaui peoples about their landscape can be connected with precolonial times?