Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

This thesis aims to improve the detection from ultra-weak single emitter by enhancing their emission properties with plasmonic nanostructures. We exploit the wet-chemically synthesized single crystalline gold nanorods (GNRs) as our basic frameworks in the whole studies, simply because of their unique…

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Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

The focus of our theoretical research is understanding the behaviour of soft condensed matter, physical matter which is deformed or structurally altered by thermal fluctuations or small stresses.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

ASLU 16

Supervisor: P.J.J. Hooykaas

Heritage Quest citizen scientists conduct research in two ways: online and in the field. Online, from their own home, they inspect elevation maps for traces of archaeological heritage.

This thesis revolves around the electronic spectroscopy of molecules in the laboratory and the search for the carriers of the diffuse interstellar bands (DIBs).

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

Due to the fact that the Frisian lands lacked major political centers in the Middle Ages and also because most of its monasteries suffered complete destruction in the second half of the 16th century, relatively few written documents concerning medieval Frisian history have survived. To analyze them…

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

In the Leadership Lab (4 EC) you will set out to tackle a topical problem presented by one of our partner organisations, and develop general leadership skills that contribute to a successful execution of the consultancy assignment.

The programme group Research Methods and Statistics offers support to researchers from a variety of research projects within Education and Child Studies.

The Leiden Institute of Education and Child Studies aims to conduct high-quality research that addresses major social issues. This inspires its BSc, MSc and PhD programmes.

The Old Observatory of Leiden is the oldest extant university observatory in the world. While students of Leiden University receive lectures in the main part of the building, the visitor center in the basement and the telescopes on the building serve the general public. Here you will find information…

The Leiden Institute of Advanced Computer Science (LIACS) of Leiden University proudly establishes the Blaise Pascal chair. The chair applies for one year and is meant to strengthen the cooperation of the Leiden computer science research with foreign institutes.

Humanities, Institute for Area Studies, Chinese Studies

The main interest of this project concerns learners’ perceived learning outcomes in massive open online courses and the factors related to their perceived learning outcomes.

Arts and leisure, Arts and leisure

The specialisations Art History and Museum Studies both engage in critical perspectives and in current practices and the development of a professional network. The specialisation Art History puts emphasis on the analysis of art works within a museal and curatorial context. Our courses, taught by art…

The specialisations Art History and Museum Studies both engage in critical perspectives and in current practices and the development of a professional network. The specialisation Museum Studies focuses on the art museum and places it in an artistic, cultural, social and political context. Our courses,…

Potential drugs that seem promising in the lab, but don’t show any activity in a person: they cost the industry an incredible amount of time and money. That’s why Indira Nederpelt focuses on a more efficient search for new drugs in her PhD, by determining the kinetics of a potential drug earlier on…

On Friday May 3rd 2013 NWO has announced that Dr. Mario van der Stelt, Division of Bio-Organic Synthesis (LIC) and Dr. Laura Heitman, Division of Medicinal Chemistry (LACDR), have been awarded with an ECHO-STIP grant for their project, entitled: “Novel target engagement biomarkers for better drug ca…

PhD Defence

Leiden biophysicists have found a new possible way to attack cancer cells. They have located ‘sinkholes’ on the cells where receptor proteins disappear from the surface. If a drug could push these proteins towards those areas, it would kill the cancer cell.

An overview of research projects at the Predictive Pharmacology group.

Lecture, Van Leeuwenhoek Lecture on BioScience

Promotor: Bas Edixhoven, Promotor: Qing Liu

We are interested in understanding the mechanics of soft materials, of which biological materials are prominent examples.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The focus throughout this thesis will be on gathering fundamental studies of the detailed structure and composition of the electrode/electrolyte interface effect on the rate and mechanism of key electrocatalytic reactions.

The origin and evolution of galaxies are closely tied to the cyclic feedback processes between stars and the interstellar medium (ISM).

ACPA offers electives in visual arts, music or music philosophy. As a student of Leiden University or the University of the Arts The Hague* you can choose these electives offered by ACPA.

In 2019 citizen scientists inspected elevation maps of the Veluwe region and discovered several thousand potential new archaeological structures. The project started as exploration into the potential of citizen science in Dutch archaeology, but developed into a fully flexed project in which citizen…

Arts and leisure, Arts and leisure

Plants are able to resist a pathogen’s attack by a dual innate immune system. The relationship between the two pathways was not clear, but it turns out that they mutually potentiate each other, as assistant professor Pingtao Ding (Institute of Biology Leiden) and colleagues (The Sainsbury Laboratory,…

Science, Institute of Biology Leiden (IBL)

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

How to make a quantitative assessment of the relative contribution to toxicity of ions and particles? Is the toxicity of nanoparticles related to their size or shape? Which physicochemical property of nanoparticles is an appropriate dose metric of nanoparticles?

The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology.

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

The Aging and Immunity group is led by Dr. Amanda Foks. In this group we aim to investigate how aged immune cells contribute to atherosclerosis and identify novel therapeutic targets and strategies to extend health span and inhibit cardiovascular disease.

How are carbohydrates processed by the immune system? Can carbohydrates be used to trigger T-cells against other conjugated antigens? Can they be used as adjuvants?

Which metabolites of sponge are influenced by individual environmental or biological factors?

This research area is focused on the development and application of novel concepts and models in the emerging area of quantitative systems pharmacology (QSP).

Key publications of the Systems Pharmacology group