Promotor: Prof.dr. P. Stevenhagen, Jan-Hendrik Evertse, Co-promotor: Pascal Autissier

We warmly welcome abstracts for Poster and Oral Communications! Abstract deadline is 15 May 2022.

This thesis describes the antimicrobial discovery strategy developed in our group, the den Hertog Group at the Hubrecht Institute. It includes a cultivation-based screening approach for novel antimicrobial agents from the source of fungi, and a bacterial time-lapse imaging approach for antimicrobial…

PhD Defence

PhD Defence

The 3rd International Workshop on Klinefelter Syndrome, Trisomy X, and XYY will be held at The Academy Building, Rapenburg 73, Leiden. It is situated in the city center, close to hotels, restaurants and attractions.

We study the link between the acoustic, behavioral and physiological health of birds and prominent pollution factors. We aim to explore causation through experimental studies on detrimental factors like traffic noise, particulate matter and chemical toxins. Our primary target is scientific progress…

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

PhD Defence

Lecture

PhD Defence

The effective treatment of tuberculosis (TB) remains a major challenge to global health.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

The potential of liposomal cancer vaccines

How does the endocannabinoid system in the zebrafish function at the molecular and phenotypic levels and how is it linked to the stress axis?

Promotor: T. Schmidt, Co-Promotor: B.E. Snaar-Jagalska

Diacylglycerol lipases (DAGLα and DAGLβ) convert diacylglycerol to the endocannabinoid 2-arachidonoylglycerol. Our understanding of DAGL function has been hindered by a lack of chemical probes that can perturb these enzymes in vivo.

Promotor: Prof.dr. J. den Hertog

Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

What are the functions of the endocannabinoid system?

N-acylethanolamines (NAEs), which include the endocannabinoid anandamide, represent an important family of signaling lipids in the brain. The lack of chemical probes that modulate NAE biosynthesis in living systems hamper the understanding of the biological role of these lipids.

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

With its instalment in 2022, the Kroese-Duijsters Symposium will provide a platform for interaction between researchers from different fields and in different career stages, from doctoral students to world-leading professors.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

Promotor: Prof.dr. J. Memelink

Promotor: P.M. Brakefield

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Ethnography and Photography in a Moroccan Berber Village

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

Nanoparticles that transport medicines to a specific part of the human body are usually broken down in the liver prematurely. Jeroen Bussmann from Leiden University has discovered a new method to prevent this from happening. Publication in ACS Nano.

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

The Leiden Institute of Advanced Computer Science (LIACS) of Leiden University proudly establishes the Blaise Pascal chair. The chair applies for one year and is meant to strengthen the cooperation of the Leiden computer science research with foreign institutes.

Due to the fact that the Frisian lands lacked major political centers in the Middle Ages and also because most of its monasteries suffered complete destruction in the second half of the 16th century, relatively few written documents concerning medieval Frisian history have survived. To analyze them…

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

We investigate emergent structures and dynamics of soft materials self-assembled from microscopic constituents.

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

Promotor: Prof.dr. E. F. van Dishoeck, Co-promotor: A. N. Heays

Promotor: E. Bouwman, Co-Promotor: S. Bonnet

The Leiden Institute of Education and Child Studies aims to conduct high-quality research that addresses major social issues. This inspires its BSc, MSc and PhD programmes.

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.