PhD Defence

PhD Defence

Description of Effects of glufosinate-ammonium on off crop vegetation.

PhD Defence

PhD Defence

PhD Defence

Intrigued by the way cells autonomously regulate their fate, we strive to understand and visualize cellular processes as the basis of Cell Signaling.

Due to the modern techniques of combinatorial chemistry and high-throughput screening, data on the biological activity of many millions of compounds is known. However, it is still very difficult to transfer this data into knowledge: if we know that compounds A and B bind to a certain protein with high…

Monoacylglycerol lipase (MAGL) is the principal enzyme responsible for hydrolysis of the endocannabinoid 2-arachidonoylglycerol (2-AG). MAGL inhibition provides several potential therapeutic opportunities, including anti-nociceptive, anti-inflammatory and anti-cancer activity.

PhD Defence

PhD Defence

Cell adhesion signaling

Establishing human induced pluripotent stem cell (iPSC) CRISPR-Cas9-based fluorescent reporter cell lines for NF-kB signalling. We will use this to enable studying the dynamic activation and downstream signalling of Toll-like receptor and cytokine signalling in iPSC-derived differentiated cells in a…

For more information regarding ongoing research projects, please contact Prof. Miranda van Eck.

How do nanoparticles bioaccumulate and biodistribute in organisms?

Can we bring novel treatment options to the clinic for UM patients with liver metastases?

Science, Leiden Academic Centre for Drug Research (LACDR)

What is the difference between a minister saying that something is possible or that it is not impossible ?

This work is dedicated to interpreting in cohomological terms the special values of zeta functions of arithmetic schemes.

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

The Data-Driven Drug Discovery Network (D4N) is an initiative by researchers from Leiden University and collaborators to join efforts in applying and developing novel techniques from data science to drug discovery and related topics from bioinformatics.

Registration is open.

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

Rembrandt painted the portraits of more Leiden alumni than we can show in the route. Discover who else posed for Rembrandt.

To an algebraic curve C over the complex numbers one can associate a non-negative integer g, the genus, as a measure of its complexity.

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

Selected publications of the Cardiovascular and Metabolic Therapeutics group.

Relevant publications of the CIGR participants.

In neonates and infants, body size, enzyme pathways, and expression and function of receptors and (target) proteins are still developing.

The disease acute myeloid leukemia (AML) is characterized by fast progression and low survival rates.

Supervisor: Anna Vlachodimou

Description of Biotic ligand models: making an inventory of available models & assessment of the variability of the predicted HC5 using the BLMs in different Dutch water types (2005 - 2007)

Bacteria caught red-handed, deeply frozen just as they were about to cause Lyme’s disease. Ariane Briegel is wildly enthusiastic about the wonders she observes thanks to three elements: a freezing technique, a camera-equipped microscope, and AI. ‘It’s fascinating. Every single cell is different.’

In the hunt for a vaccine against cervical cancer, fundamental knowledge about the immune system and organic chemistry have been brought together and have already resulted in a vaccine that is now being tested in clinical trials. Scientists are now working hard on an improved variant.

Meet the organising committee.

The theater studio is a multifunctional space of 9.4 x 8 m, with wooden floor, mirrors and curtains. Music system and piano available.

The dance studio is a space of 7 x 10 m, with wooden floor and barre. Music system available

The music studio is a multipurpose room measuring 9.4 x 8.9 m, with marmoleum on the floor and 40 chairs. Music system and piano available.

This thesis consists of five chapters on how to construct prediction sets for different types of data and models in a parametric or nonparametric Bayesian paradigm.

In this thesis, the researcher developed a nanosystem based on the metallophilic Interaction between cyclometalated complexes.

Promotor: Prof.dr. M. de Jong, Co-Promotor: Dr. A.J. Heijboer

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Pharmacogenetics is nowadays increasingly incorporated in the clinic to better predict pharmacokinetics and optimize dosing regimens of drug treatments. While this approach has been successful and improved our prediction of drug metabolism, drug levels within patients may still commonly deviate between…

PURPOSE: To monitor the biodistribution of IgG1 aggregates upon subcutaneous (SC) and intravenous (IV) administration in mice and measure their propensity to stimulate an early immune response.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

PhD student Esmee Koedoot studied the underlying processes responsible for metastases in a dangerous type of breast cancer. She hopes to find new possibilities to fight the disease. In December 2019 she obtained her doctorate cum laude.

Moving Week will take place between 20-21 August 2022. In order to prepare yourself for your Moving Day, we want to share with you some more info, and what to expect before this date. DUWO - our student housing partner that deals with LUC's housing will be in touch with you in the summer to start…

PhD Defence

The Science Council is an advisory committee to the Board of the Institute and consists of the full and associate professors of the Institute.