Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

Metabolic diseases are a burden on the European population and health care system. It is increasingly recognised that individual differences with respect to history, lifestyle, and genetic make-up affect disease progression and treatment response. A Systems Medicine approach, based on computational…

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).

The skin is our natural barrier and lipids are a key part of this barrier. In the outer skin layer, the stratum corneum (SC), lipids form a densely organized structure dependent on the composition of these lipids.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Can animal venoms yield novel antimicrobial peptides?

We are developing biology-driven platforms to measure metabolites based on liquid chromatography-mass spectrometry (LC-MS), gas chromatography-MS (GC-MS), and capillary electrophoresis-MS (CE-MS).

Activity-based protein profiling (ABPP) is a functional proteomics technique for directly monitoring the expression of active enzymes in cell extracts and living cells. The technique relies on irreversible inhibitors equipped with reactive groups (warheads) that covalently attach to the active site…

What are the functions of the endocannabinoid system?

A major goal of ABS research is to overcome one of the major bottle-necks in metabolomic research: the lack of a high-throughput infrastructure in which thousands of samples can be processed in a standardized and cost-effective way (max. a few tens of Euro’s per sample for a full metabolome profile).…

TRANSVAC is a collaborative infrastructure project funded by the European Commission (EC), initially under the 7th Framework Programme (FP7) and currently under Horizon 2020. The project is a joint effort of leading European groups working in the field of vaccine development, and is coordinated by…

Metabolomicshas emerged as an important discipline to study molecular and cellular processes in living cells and organisms with the ultimate aim to obtain an answer to a given biological/clinical question.

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

Ancient Greek was spoken in a large number of different dialects. Although we do not find direct evidence for syllabic liquids in any of our sources, comparative evidence shows that these sounds must have been present in Proto-Greek, and that they were retained until comparatively recently in the prehistory…

In this Thesis, novel charge induction mechanisms of ionic liquids are treated, tested and experimented on complex oxides, in particular cuprates.

The present study explores the role of water in the ancient Roman city of Ostia.In antiquity, Ostia was situated at the intersection of the Tiber River and the Mediterranean Sea, and acted as one of the harbour cities of Rome for several centuries.This study investigates how water was acquired, used,…

Water, Urbanism, and Sustainability in Roman Ostia

LCD screens use liquid crystals which have a high degree of order, even though they form a fluid. A new theory maps out the interplay between order, temperature and symmetry. Publication in Physical Review X.

The filamentous bacteria Streptomyces are widespread inhabitants of terrestrial soils.

We study the interplay of topology and geometry with chirality for several passive and active systems, employing both analytical and numerical methods.

This thesis explores interfacial conductance and electric field-effects in LaAlO3/SrTiO3 heterostructures.

111 years ago, Heike Kamerlingh Onnis liquified helium for the first time, a tour the force that netted him the Nobel prize. It took a laboratory of a size rarely seen. Now, ultracold helium has become a commodity for physics research. In Wolfgang Löffler's lab, it is ready at hand thanks to a coffee…

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

Promotor: Prof.dr. T. Hankemeier, Co-Promotor: R.J. Vreeken

Promotor: J. Zaanen

After 2 years of planning, designing, testing and adjusting, the brand-new low-vibration physics lab at the new Gorlaeus Building of the Science Campus is working like a charm and ready to make its mark in the world of science. Also, the renewed facility for the production of liquid helium is all do…

Promotor: Prof.dr. M.L. van Hecke, Co-Promotor: Prof. dr. V. Vitelli

The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.

Publication in Proceedings of the National Academy of Sciences.

PhD Defence

PhD Defence

Lecture

Lecture

PhD Defence

Inaugural Lecture

PhD Defence

PhD Defence

Lecture

Lecture, Archaeological Forum

- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

The Cryogenics Department has a liquid helium production unit and an automatic liquid nitrogen filling plant.

Due to the corona pandemic the 12th International Metabolomics Workshop has been postponed. The event will not take place from March 30 to April 17 2020. We will inform you via this website as soon as we have a new date.

PhD at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

The Biologics Formulation Group is led by Prof. Wim Jiskoot. A major challenge in the formulation of biopharmaceuticals is to overcome their inherent instability during production, storage, transportation, handling and administration. We are studying underlying mechanisms of degradation of biopharmaceuticals…

What are the mysteries behind soft condensed matter?