This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

Nobody is better qualified to tell you what it is like to work at Leiden University than the employees themselves. Watch the videos and meet your future colleagues. They will be happy to share their experiences with you.

Promotor: Prof.dr. E.J.J. Groenen

Emeritus professor at the Natural Products Laboratory, Institute of Biology, Leiden University - the Netherlands

The Graduate School of Science has a centuries-old tradition in cutting edge education and research in science.

Promotor: Prof.dr. J. Kuiper

Microbial rhodopsins are photosensitive pigments implemented in the growth and adaptation of a large population of microorganisms.

Promotor: H.S. Overkleeft, Co-promotor: M. van der Stelt

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij

The Supramolecular & Biomaterials Chemistry group comprises the PIs Alexander Kros, Roxanne Kieltyka, Gregory Schneider and Sander Wezenberg, and is active in the field of self-assembly of amphiphilic peptides and applying them in supramolecular chemistry.

What are the functions of the endocannabinoid system?

Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.

This thesis describes the design, characterization and application of dextran based crosslinked network.

Promotores: Prof.dr. J. Kuiper, Prof.dr. P.H.A. Quax

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

With its instalment in 2022, the Kroese-Duijsters Symposium will provide a platform for interaction between researchers from different fields and in different career stages, from doctoral students to world-leading professors.

Cardiovascular syndromes are the major cause of death in Western societies.

Plants, algae and cyanobacteria have the amazing capacity to perform delicate photophysical and photochemical processes of light capture, excitation transfer, charge separation and catalysis in fluctuating living environments. As a consequence, photosynthetic proteins and membranes form dynamic architectures.…

Science, Leiden Academic Centre for Drug Research (LACDR)

At the division of Biopharmaceutics, we aim to develop and test new therapeutic approaches to limit or even prevent the development of atherosclerosis in order to reduce the number of acute cardiovascular syndromes such as myocardial infarction or stroke.

Lecture, Lecture part of a series

Selected publications of the Cardiovascular and Metabolic Therapeutics group.

How is it that some covid-19 patients are affected much worse than others? Can we predict beforehand which of them will develop critical symptoms Professor Thomas Hankemeier, together with a diverse consortium of universities, academic hospitals and industrial partners, is looking for the answers to…

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

To be eligible for Industrial Ecology at Leiden University and Delft University of Technology, you must meet the following admission requirements.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Promotores: H.S. Overkleeft, G.A. van der Marel, Co-promotor: B.I. Florea

Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.

Prostate cancer (PCa) is one of the most prevalent cancer in males.

In this thesis, a system pharmacology approach, integrating metabolomics, pharmacology and chemical biology, was applied to understand and modulate the endocannabinoid system across different model systems (cells, zebrafish, mice and humans).