494 search results for “lipid metabolism” in the Public website
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Key publications
Key publications of the Biomedical Microscale Analytics group.
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Bio-organic Synthesis
The research in the Biosyn group is focused on the design, synthesis and function of the four major types of biomolecules: nucleic acids, carbohydrates, peptides and lipids and hybrid structures thereof. These biomolecules and their derivatives are used in drug discovery and chemical biology, to develop…
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Hit and Lead Optimization
The goal of hit and lead optimization is to optimize suitable chemical starting points that can modulate a drug target. The methods and technologies used are similar to those in Hit Discovery, but once the compound has shown activity in an animal model, it moves from 'hit' to 'lead.'
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Ischemia/reperfusion injury: a metabolic meltdown
PhD defence
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Multimodality Imaging in Metabolic Heart Disease
PhD defence
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Metabolic regulation of differentiation and maturation
PhD defence
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BioTherapeutics (MSc)
The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…
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Bernd Schneider
Dr. at Max Planck Institute for chemical Ecology, Jena - Germany
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Unlocking Nature’s Pharmacy from Bogland Species
Development of Natural Resource for New Medicines
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Genetic and methodological aspects of statin-induced lipid response
PhD defence
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Research
Research lines within the Pharmacy group:
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Macrophages and atherosclerotic lesions
Macrophages and atherosclerotic lesions The infiltration of monocytes in the arterial wall, their differentiation to macrophages, and the subsequent accumulation of cholesterol in these macrophages initiate the process of atherosclerosis. We study the importance of specific genes in macrophages for…
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Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
PhD defence
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Towards artificial photosynthesis on the lipid bilayer of liposomes
PhD defence
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mRNA and Drug Delivery with Lipid-based Nanoparticles
PhD defence
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Lipids as therapeutic targets for barrier repair in skin diseases
PhD defence
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Historic Chinese Materia Medica revisited
What are the differences between the trade in Chinese herbal drugs in Europe between 1800 and now? Can we see the major metabolic changes after 200 yours?
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Metabolomic characteristics of Catharanthus roseus plants in time and space
Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa
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Harnessing the soil microbiome for improved stress tolerance in crop plants
Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?
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From Descriptive to Predictive Pharmacology in Children using Semi-Physiological population modelling
An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.
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Mathematics-based strategies for repairing tumour blood vessels
How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?
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Regulatory networks in Streptomyces
We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.
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Enabling volume-restricted metabolomics using next-generation microscale analytical tools
Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.
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Multi-omics studies of the control of growth and antibiotic production of Streptomyces
Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).
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Novel Pathways in Cholesterol Metabolism to Combat Cardiometabolic Diseases
PhD defence
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Combatting metabolic disease. Ethnic aspects, mechanisms and novel treatment strategies
PhD defence
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CE-MS for metabolomics: advancing performance and detection sensitivity
The major and ultimate aim of metabolomics is to obtain an answer to a specific biological or clinical question.
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Single cell technologies for mechanobiology and mechanopharmacology
Mechanobiology is a major area in biology, however, mechanics is currently a missing element in drug development pipelines. This has led to a high cost for the society. Mechanotoxicity of drugs often appears as a long-term side effect of drugs, and has led to removal of drugs from the market. Furthermore,…
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Concepts and applications for evidence-based dosing in morbidly obese patients before and after weight loss surgery
Promotor: C.A.J. Knibbe, Co-promotores: H.P.A. van Dongen, B. van Ramshorst
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Exploration of the endocannabinoid system using metabolomics
PhD defence
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Regulation of signal transduction pathways by hypoxia in breast cancer subtypes
PhD defence
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Kroese-Duijsters Symposium 2022: Molecular Receptors and Machines in Lipid Bilayer Membranes
Conference
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Preclinical validation of putative targets in cardiovascular and metabolic disease
PhD defence
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Studies on molecular basics of metabolic syndrome in zebrafish
PhD defence
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
PhD defence
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The Synthesis of Chemical Tools for Studying Sphingolipid Metabolism
PhD defence
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Ecology and genomics of Actinobacteria and their specialised metabolism
PhD defence
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This Week's Discoveries | 11 February 2020
Lecture
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Sarantos Kostidis
Dr. in Biomedical NMR spectroscopy, LUMC, Leiden - The Netherlands
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Macrophages and atherosclerotic lesions-projects
For more information regarding ongoing research projects, please contact Prof. Miranda van Eck.
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Biomedical Microscale Analytics
The Biomedical Microscale Analytics group is led by Dr. Rawi Ramautar. In present-day metabolomics, and bioanalysis in general, the analytical toolbox used encounters difficulties for the analysis of limited amounts of biological samples. As a result, a significant number of crucial biomedical/clinical…
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Joachim Kopka
PhD at the Max Planck Institute of Molecular Plant Physiology, Golm – Germany
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Galactofuranose biosynthesis in the filamentous fungus Aspergillus niger
This project aims to further understand the molecular details related to the biosynthesis and function of Galf containing glycoconjugates in fungal Aspergillus spp.
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Lipid model membrane systems as a tool for unraveling the underlying factors for skin barrier dysfunction
PhD defence
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On the geometry of demixing: a study of lipid phase separation on curved surfaces
PhD defence
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Gaining control of lipid-based nanomedicine by understanding the nano- bio interface
PhD defence
- Prof Dr André Kessler
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Mechanistic modelling of drug target binding kinetics as determinant of the time course of drug action in vivo
Drug-target binding kinetics determine the time course of the central event in pharmacotherapy: Drug-target interaction.
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Iminosugars as glucosylceramide processing enzymes inhibitors: design, synthesis and evaluation
This Thesis describes the design, synthesis and evaluation as glycoprocessing enzyme inhibitors of focused libraries of iminosugars.