526 search results for “latent variabele models” in the Public website
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More efficient drug development with the help of computer models
The coronavirus has the world in its grip. Finding a cure has never been more important. Unfortunately, the development of new drugs for treatment of the COVID-19 disease caused by the virus and development of a vaccine are complex, lengthy, and above all costly processes. With the help of computer…
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New model predicts ‘yoyo’ orbits around black holes
Stars orbit black holes while jumping up and down. This is the prediction of a theoretical model developed by Leiden physicist Satish Kumar Saravanan, based on Einstein’s theory of relativity. He defends his PhD thesis on July 7th.
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Multiscale mathematical biology of cell-extracellular matrix interactions during morphogenesis
During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.
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Galaxy formation and the structure of the Universe
Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)
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The integration of meta-analysis and classification & regression trees: meta-CART
In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).
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Advances in Survival Analysis and Optimal Scaling Methods
This thesis is based on five papers on several topics.
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Quantifying the toxicity of mixtures of metals and metal-based nanoparticles to higher plants
Promotores: Prof.dr. W.J.G.M. Peijnenburg & Dr. M.G. Vijver
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Guiding evolutionary search towards innovative solutions
Promotors: Prof.dr. T.H.W. Bäck, Prof.dr. B. Sendhoff (Technische Universität Darmstadt)
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Rosaleen March
Science
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Ruben Huele
Science
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Sebastiaan Deetman
Science
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Software development by abstract behavioural specification
The development process of any software has become extremely important not just in the IT industry, but in almost every business or domain of research.
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Jinhui Zhou
Science
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Amie Corbin
Science
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Viktor Pirmana
Science
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David Shakouri
Faculty of Humanities
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Zhongxiao Sun
Science
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Nicolas Navarre
Science
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Myrthe Veenman
Faculteit der Sociale Wetenschappen
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Carlotta Rieble
Faculteit der Sociale Wetenschappen
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Mathilde Verdam
Faculteit der Sociale Wetenschappen
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Carina Harpprecht
Science
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Anne Uilhoorn
Science
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Henk Kelderman
Faculteit der Sociale Wetenschappen
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Weilin Huang
Science
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Fulco Scherjon
Faculteit Archeologie
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Dirk-Jan Kok
Science
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Micha Drukker
Science
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MULTIPLY - MULTIscale SENTINEL land surface information retrieval Platform
Aim: To develop and enable application of a practical, flexible, user-friendly platform to provide the scientific community with a tool to generate land surface products and its associated uncertainties and exploit these for data-intensive science.
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Joost Beltman
Science
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Marco Spruit wants to develop a language model to improve healthcare
By making smart use of available data, the health and care of people can be substantially improved. Marco Spruit wants to use language and machine learning in the coming years to identify and solve the biggest care issues in the region of The Hague. He has been appointed Professor of Advanced Data Science…
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dr. ir. Hai-Xiang Lin working on Data Analytics for Environmental Modelling joins CML
Prof.dr.ir. Hai-Xiang Lin is appointed on 1 March 2015 as part-time professor on Data Analytics for Environmental Modelling at CML on behalf of the R. Timman foundation. He will join the CML-department of Industrial Ecology. He has a position at the Department of Applied Mathematics at the Faculty…
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Global fitness maximising approaches to evaluate the trade-offs involved in the evergreen and deciduous conundrum
Which traits and/or trade-offs determine benefits of being deciduous or evergreen?
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Leiden University wins best position paper at the 2019 Model ICAO
The 2019 Model ICAO took place from 21-24 May at the ICAO headquarters in Montreal.
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Weathering the Ice Age
Where did species survive the cold cycles of the current Ice Age?
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‘Seeing voices’: the role of multimodal cues in vocal learning
Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?
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Mathematical model helps to explain the formation of spine and ribs
Mathematical biologists from Leiden have developed a model that helps to explain how the spine and vertebrae, among other things, form during embryonic development. The same process, the other way around, plays a key role in cancer metastasis. Publication in iScience.
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Stochastic resetting and hierarchical synchronisation
Stochastic resetting is simple enough to be approached analytically, yet modifies stochastic processes in a non-trivial way.
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Statistical Science
The research programme Statistical Science is concerned with the analysis and interpretation of masses of data, the quantification of uncertainty using probability models, and the development and benchmarking of algorithms and methods with these aims.
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Proteins in harmony: Tuning selectivity in early drug discovery
This thesis describes the importance of being able to control the selectivity of potential drug candidates.
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Actors at work
Promotor: F.S. de Boer Co-promotor: P. T. de Gouw
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NMR studies of protein-small molecule and protein-peptide interactions
Promotor: M. Ubbink, Co-promotor: G. Siegal
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Calculated Moves: Generating Air Combat Behaviour
By training with virtual opponents known as computer generated forces (CGFs), trainee fighter pilots can build the experience necessary for air combat operations, at a fraction of the cost of training with real aircraft.
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Sanne Willems
Faculteit der Sociale Wetenschappen
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A family affair? Exploratory insights into the role of family members of those who joined jihadist groups
Since 2012, thousands of individuals have traveled from Western countries to join jihadist groups in Syria and Iraq. While much has been written about these individuals, only sparse attention has been paid to the social environment of these jihadist travelers and, more specific, the role of family members…
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Tracing Policy-relevant Information in Social Media: The Case of Twitter before and during the COVID-19 Crisis
This paper written by Vydra and Kantorowicz answers the research question ‘What policy-relevant information does Twitter contain?’ as well as the research question ‘How does this information change between a period of normalcy and a period of crisis?’
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The development and prevention of social anxiety in youth
What are the developmental pathways to social anxiety (disorder), the causal processes and maintaining factors? How do these factors interact in the development of social anxiety disorder? How can this knowledge be used to design and implement effective preventive intervention programs for youth?
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Improving vegetation representation in Multi-sensor Earth Observation Products through phenology and trait-based priors
What are the behaviours of plant traits throughout various points in the growing season in a radiative transfer model framework and how well can this knowledge be integrated through data assimilation to provide priors for robust local and global vegetation products and analysis?