The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Promotores: A.P. IJzerman, H.W.T. van Vlijmen

Science, Leiden Institute of Chemistry (LIC)

1. To what extent do metallic NPs added to soil extractions change the activity, abundance, or community composition of microbes? 2. How do the effects of metallic NPs on soil microbes differ from the effects of the ions shedding from corresponding NPs?

Promotor: Prof.dr. J.W.M. Frenken

This dissertation provides crucial but as yet missing empirical data on the tone accent opposition in the so-called

To what extend can coercive diplomacy coerce a State to abandon its controversial nuclear program? Out of three case studies, namely Iran, Libya and South Africa, Jean Yves Ndzana’s PhD research project aims at studying the conducive conditions of coercive diplomacy.

Source: Org Biomol Chem, Volume 13, Issue 8, pp. 2407-22 (2015)

What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…

This thesis aimed to investigate core cross-linked polymeric micelles (CCPMs) and expand their potential for the delivery of hydrophobic drugs and co-factors.

Brain researcher Elseline Hoekzema has discovered that the structure of the brain changes during pregnancy, particularly those areas related to social functions. These changes persist for at least two years after the mother gives birth. Publication in Nature Neuroscience on 19 December.

On March 12th, Jonathan Brown succesfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Jonathan on this great result.

The need for knowledge among practitioners and the lack of an academic knowledge base for specifically collective arrangements of social work in the Netherlands were the reason for Anouk de Koning, Femke Kaulingfreks and Maartje van der Woude to start working on a Dutch Research Agenda (NWA) application…

To study how planetary systems come into existence we study much younger systems still in formation.

My work is motivated by the necessity to extend Standard Model of Particle Physics in order to explain three observed phenomena that this great theory fails to accommodate

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Manufacturers produce high-end technology mostly top-down with large machinery, but small particles are able to build structures by themselves from the bottom up. A major challenge is that these particles easily clump together. Leiden physicist Daniela Kraft has developed a method to use this phenomenon…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

We are cosmologists, in other words we use physics to study the Universe, how it started and evolved into the structure that we observe around us.

What are the 'dark' components of the universe?

One of the effects of climate change is the phenomenon of desertification, a process that occurs in semi-arid and arid areas and causes land degradation as well as vegetation loss. Due to the lack of resources, vegetation self-organizes to sustain itself by forming large-scale spatial patterns.

A new executive board has been installed at NeCEN, a state-of-the art facility that offers the most advanced cryo-electron microscopes worldwide. The new board members are full of excitement: what are their ideas for the future of the facility?

The European Union has invested ten million euros in the so-called iNEXT-Discovery consortium. The goal of this new consortium is to enable European researchers to extend innovative structural biology research. The Netherlands Centre for Electron Nanoscopy (NeCEN) is also part of iNEXT-Disovery, which…

Using musical cues to learn a physical task significantly develops an important part of the brain, according to a new study co-authored by Leiden psychologist Rebecca Schaefer. The results are published in the journal Brain & Cognition.

In the discs of dust and gasses around young stars, mysterious structures occur. Together with professor Ewine van Dishoeck, PhD student Paolo Cazzoletti investigate how we can explain these forms, such as rings, spirals and holes. On 12 December, he will defend his thesis.

Religions involve belief in the unbelievable: in evil spirits causing disease, in souls surviving death, and in gods punishing wrongdoers and blessing the just. Cognitive studies suggest that humans are predisposed to speculate about fate and divine agency, but support from so-called ‘plausibility structures’…

This thesis investigates the connection between tonal realization and tone change (tone sandhi) in Wenzhou Chinese, and whether and how such a connection is conditioned by prosodic structure and focus marking.

In the search for new medicines against diseases such as cancer, a Leiden team has developed a new workflow. This approach combines artificial intelligence (AI) with molecular modelling and is suitable for finding unknown and innovative drug structures, the researchers proved.

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Tell Sabi Abyad is a major Late Neolithic settlement mound in Northern Syria, belonging to the seventh and early sixth millennium bc. This book presents the results of large-scale fieldwork conducted at the site between 1994 and 1999, under the auspices of the Netherlands National Museum of Antiquities…

For centuries, astronomers have studied the universe by collecting light signals. Since 2015, the confirmation of an important prediction of Einstein allows us to explore the universe in a new way: through gravitational wave radiation. Astronomy PhD candidate Valeriya Korol proposes to use these gravitational…

A review of Elke Devroe's participation in the European Society of Criminology of 2016 : The first conference of the European Society of Criminology was held in 2000 in Lausanne. Now, 16 years later and lots of new ESC-members later, the 16th Annual conference of the European Society of Criminology…

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

An organized overview of the current global fungal diversity, that is what Irene Martorelli and colleagues try to achieve with the new MycoDiversity Database (MDDB) she builds in collaboration with Naturalis Biodiversity Center. The new database will make it easier and quicker to observe which fungi…

Imprint of Action is the first large-scale study focussing entirely on sociocultural impact in archaeology and, as such, is explorative in nature; it provides unique insights into the workings of interaction and participation in archaeological events, and openly shares qualitative and quantitative research…

The 2004 Indian Ocean tsunami caused immense destruction and over 170,000 deaths in the Indonesian province of Aceh. The disaster spurred large-scale social and political changes in Aceh, including the intensified implementation of shari‘a law and an end to the long separatist conflict. After the Tsunami…

On 7 December 2021, Georgina Kuipers defended the thesis 'Beschadigd vertrouwen'. The doctoral research was supervised by Prof. W. den Ouden and Prof. M.A. van der Steen (EUR).

Latent variable modeling of students' solution strategies and performance

Researchers at LIACS are working to devise the computers of tomorrow that will be the backbone of the Cloud and Edge computing paradigms as well as the Internet of Things. In this respect, we are involved in research and development of high performance computing systems, embedded & real-time computing…

Cathodic corrosion is a relatively unknown phenomenon that can severely etch metallic electrodes at cathodic (negative) potentials.

First author Rubin Dasgupta, PhD student at the Biophysical Organic Chemistry & Macromolecular Biochemistry groups at the Leiden Institute of Chemistry has made the cover of the June edition of Solid State Nuclear Magnetic Resonance.

Promotor: Prof.dr. T. Hankemeier, Co-Promotores: T. Reijmers, L. Coulier

Lecture

There seem to be genes that influence how our brains develop over time. A large international consortium has discovered this with an extensive study. The results of the study were recently published in Nature Neuroscience.

Describe and identify what dosimetry parameters are of importance to interpret dose-response relationships (eg., mortality, sub-lethal, growth or reproduction inhabitation, DNA damage and reactive oxygen species, etc. ) for metal-based nanoparticles? How to develop quantitative models that enable to…

Errors are everywhere, and mechanical failures are especially common: buckled grain silos and cracked support columns are, justly, seen as an issue to be avoided.

The aim of this project is to explore the use of statistical interaction models to quantify cross-omics and omics-drug interactions in large-scale clinical and experimental datasets