How can we manipulate the biotic and abiotic environment to increase thrips resistance in tomato and chrysanthemum? More specifically we ask: How can plant secondary metabolites that are not soluble in water be delivered to plants in seed coating or root dipping treatment? Can bacteria be used to…

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

Promotor: W.Th.F. den Hollander

What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?

Scientists are split over whether the benefits some microdosers experience are a placebo effect or something more. Michiel van Elk talks about his research and the effects of psychedelics, in the New York Times, as noticed by the BDNews24.com.

Researchers of the Leiden University Medical Centre (LUMC) and the Leiden Institute of Chemistry have made an important discovery about the commonly used anti-cancer drug doxorubicin. They have found a way to reduce its side effects without sacrificing the effectiveness of the medication. This is encouraging…

Using N2 dissociation on Ru(0001) as a representative showcase (for catalysts employed in the Haber-Bosch process), we have shown for the first time that non-adiabatic effects can substantially reduce a molecule’s dissociation probability on a metal surface. These effects are currently completely unaccounted…

We are confronted on a daily basis with news about the Corona virus and its consequences. We read alarming headlines like 'Dutch becoming increasingly anxious about Corona virus' or 'Huge fears and stress about Corona crisis'.

We consider the propagation of electrical signals through nerve fibres.

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Promotor: Prof.dr. M. Ubbink

This week sees the first edition of the textbook Mouse&Manuscript published online. Mouse&Manuscript is a collection of interactive lessons on codicology and oriental manuscripts. Its aim is to stimulate teaching on codicology in and outside of the classroom, and to contribute to the disclosure of Leiden…

This dissertation contains four works during my PhD. Different biomaterials have been designed based on coiled-coil peptides. These biomaterials have a range of applications, inclusing drug delivery, cell sorting to cell-cell fusion.

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Cryogenic electron microscopy (cryo-EM) is a powerful technique used to visualize the inside of cells and to study specific protein complexes. Within this thesis, I describe the use of various cryo-EM techniques to gain insight into the structural changes of the human pathogen, Vibrio cholerae, as it…

This thesis described the development of novel scanning tunneling microscopy techniques to investigate strongly correlated electronic states in quantum matter.

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

Which plant leaf characteristics are involved in thrips resistance in tomato?

LACDR, the Leiden Institute for Drug Research, developed better tolerated excipients to prevent adverse effects related to the surface of nanosized drugs such as vaccines. LADCR professor of Biopharmacy Matthias Barz and Polypeptide Therapeutic Solutions (PTS) are collaborating to develop processes…

The Life in Custody (LIC) Study comprises a large-scale research project into prison climate and the quality of prison life in Dutch prisons.

By reforming agriculture in targeted areas, we can protect the Natura 2000 areas much more effectively. This is what Jan Willem Erisman of Leiden University and Ton Brouwer of Gispoint consultancy write in a new report. They have created a special, nitrogen map of the Netherlands that shows the areas…

On 29 October, seven innovative lecturers from different faculties will join the existing ten fellows of the Leiden Teachers' Academy. The current fellows have been engaged for the past year in implementing their innovation projects. How are these progressing?

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

The Hazelhoff Centre for Financial Law organized the third edition of the workshop ‘Principles for effective negotiations in legal practice’ on 5 June 2018.

Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?

We aim to develop a drug-delivery method based on the production of biomolecules directly at the target site.

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

In this blog post Saskia Postema and Jan Melissen claim that Chinese UN celebrities’ activism under Xi Jinping has become aligned with the Chinese leadership’s ambitions.

How does ICT affect society? Mirjam van Reisen, professor Computing for Society at the Leiden Centre of Data Science, is intrigued by this question. We speak with her about innovation, changes in health care, and mobile human trafficking. ‘Innovation has many benefits, but it can also be very disrup…

The Collective Experience of Empathic Data Systems (CEEDs) consortium developed novel integrated technologies that support experiencing, analysing and understanding of very large datasets.

Radio interview with CML researchers Martina Vijver and Henrik Barmentlo in the NTR radio programme: Nieuws en Co on Friday 24 March 2017. The researchers gave an overview of the research which will be conducted in the Living Lab in the coming year. The Living Lab is located in the BioScience Park in…