Duality, stochastic processes

Promotor: F.H.J. Redig, Co-Promotor: W.T.F. den Hollander

Promotor: W.Th.F. den Hollander

Brownian motion is the random motion of (colloidal) particles due to collisions with the atoms and molecules of the solvents, which are moving due to temperature.

This thesis discusses the discovery potential of Intensity Frontier experiments.

In this research, for the first time a detailed description as well as systematic and comparative analysis of the final particle system in Chinese are provided.

Interaction between Legal Systems acknowledges that law-making and law enforcement are increasingly taking place on various levels: in a global context, in EU context, on a national level and in a private law framework. These levels influence each other, sometimes directly, on the basis of a hierarchical…

Promotor: W.Th.F. den Hollander, Co-promotor: F.R. Nardi

Our research primarily focuses on the early universe and its origins in theories that go beyond the Standard Model of particle physics.

The miniaturization of machines towards the micron and nanoscale requires the development of joint-like elements that enable and constrain motion. We developed a facile method to create colloidal joints, that is, anisotropic colloidal particles functionalized with surface mobile DNA linkers that control…

A couple of years ago, theoretical physicist Carlo Beenakker tracked down the Majorana particles and inspired Leo Kouwenhoven from TU Delft to try to create them in a superconducting nano-structure. He succeeded in doing so in 2012, and the news made headlines around the world. But a lot of work still…

The external tissues of plants and animals are colonized by microbial communities termed microbiota. When organisms are exposed to environmental pollutants, these substances will therefore encounter microbiota at the exposure interface.

Promotor: W. Jiskoot, Co-promotor: A. Hawe

My work is motivated by the necessity to extend Standard Model of Particle Physics in order to explain three observed phenomena that this great theory fails to accommodate

The intracluster medium (ICM) is a hot, tenuous and X-ray emitting gas that pervades galaxy clusters.

The purpose of this study was to investigate the formation and growth kinetics of complexes between proteins and oppositely charged polyelectrolytes.

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

We have studied the impact of particle shape anisotropy, multivalent interactions and flexibility on systems of micron-sized colloidal particles.

Particles are omnipresent in biopharmaceutical products. In protein-based therapeutics such particles are generally associated with impurities, either derived from the drug product itself (e.g. protein aggregates), or from extrinsic contaminations (e.g. cellulose fibers).

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

It is an established fact that the Standard Model has to be extended to explain the so-called Beyond the Standard Model (BSM) phenomena: dark matter, matter-antimatter asymmetry of the Universe and neutrino flavour oscillations.

The lipid membrane is a basic structural component of all living cells. Embedded in this nanometer-thin barrier, membrane proteins shape the membrane and at the same time respond to the shape of the membrane.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

In this thesis we investigated the ability of two-photon multifocal microscopy for single-molecule microscopy in live cells and organisms.

This study explores regional variation in the use of utterance-final particles by analyzing spoken Taiwan Mandarin data recorded from spontaneous conversations.

This ecological community has long been known to affect host biology, and their diverse roles have been further clarified in recent years following numerous studies of animal:microbiota interactions in diverse systems.

PhD defence

Light obscuration (LO) is the current standard technique for subvisible particle analysis in the quality control of parenterally administered drugs, including therapeutic proteins.

Gold nanorods are biocompatible nanoparticles that present an excellent two-photon signal that can be used to get high spatial resolution inside living cells. Gold nanorods are photostable and therefore can be followed inside cells for long time, with possible applications as trackers in live cells.

What is the connection between materials with weak and strong gravitational interactions?

The thesis addresses the long-term dynamical evolution of hierarchical multiple systems.

This handbook provides a resource for those already familiar with some kinds of micro-particles who wish to learn more about others, or for those just starting out in the study of microremains who wish to have a broad understanding about microscopic archaeology.

What is Interaction between Legal Systems (ILS) and what does it entail as research profile area at Leiden Law School? More on this at the kick-off event of ILS 2.0. This will take place on Wednesday 26 October 15.00 – 17.00 in the Grotiuszaal (A051 KOG). The afternoon will be closed with drinks at…

Which microorganisms live near and inside plant roots? How do they contribute to plant health? Can microorganisms be employed in plant protection?

How does global change across time and space lead to convergence and loss of variation or increasing diversity and conflict?

Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken

How do social and political developments influence the process of meaning-making in different parts of the world? Why is a particular discourse interpreted in numerous ways depending on the context it is produced and propagated? And how are culture, politics, history, and language intertwined?

Fostering multi-polar perspectives that engage more connected, nuanced and pluralistic understandings of the world. Global Interactions encourages and supports research that provides significant new insights on these global processes across time and space.

Media & interaction is where artificial intelligence and machine learning meet philosophy, cognitive science, and the creative arts. Examples of research questions in this domain are: 'Can an algorithm be creative by human standards?', 'Can creative processes, such as composing music or writing poetry,…

Membrane proteins and membrane interactions of proteins are studied by spin label EPR. Intact, native membranes, vesicles of all sizes and nano-disks can be investigated, because the size of the object does not matter in EPR. Whereas solution NMR is limited to micelles (a few nm in diameter), by EPR…

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

Media & interaction is where artificial intelligence and machine learning meet philosophy, cognitive science, and the creative arts. Examples of research questions in this domain are: 'Can an algorithm be creative by human standards?', 'Can creative processes, such as composing music or writing poetry,…

Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.

The Computer Systems, Imagery & media (CSI) research programme performs research on methods and techniques for the design, implementation and application of advanced computer systems, in particular parallel, distributed and embedded computer systems.

Many biological processes occur by biomolecules coming together and organizing into specific clusters without being bound to each other. These interactions range from clustering, transiently interacting (kiss and run), or assembling to multimeric units that can only function in conjunction. The hydrogen…

Mycoheterotrophy is a particular mode of life in which plants obtain carbohydrates from their associated fungal partners, instead of by using photosynthesis.

This thesis focus on the interaction between M dwarf stellar winds and Galactic cosmic rays and the possible effects on the habitability of exoplanets.

Promotor: J.N. Kok, Co-promotor: H.J. Hoogeboom

Promotor: C. W. J. Beenakker, Co-promotor: J. K. Asboth