588 search results for “innate immunity” in the Public website
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Immune modulation by helminths and the impact on the development of type 2 diabetes
PhD Defence
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Respiratory tract infection: prevention, early detection and attenuation of immune response
PhD Defence
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resistance of Human papillomavirus- infected or -transformed cells to Th1 immunity
PhD Defence
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The NKG2A / HLA-E axis a novel target for immune checkpoint therapy
PhD Defence
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Outcome after Paediatric Stem Cell Transplantation for Inborn Errors of Immunity
PhD Defence
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The Anti-Citrullinated Protein Antibody immune response and its effector functions in Rheumatoid Arthritis
PhD Defence
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Immune regulation by CD4+CD49b+ T cells & B cell responses in arthritis
PhD Defence
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metabolomics to probe oxidative stress, inflammation and systemic immunity
PhD Defence
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Control of Western flower thrips through jasmonate-triggered plant immunity
PhD Defence
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Insights from modeling metabolism and amoeboid cell motility in the immune system
PhD Defence
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Immune parameters affecting maternal tolerance towards the fetus in normal and aberrant pregnancies
PhD Defence
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Safety and efficacy after immunization with Plasmodium falciparum sporozoites in the controlled human malaria infection model
PhD Defence
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T cell immunity against MHC-I low tumors in mouse models
PhD Defence
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Mast cell mediated immune modulation in experimental Rheumatoid Arthritis and atherosclerosis
PhD Defence
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Systems biology as a compass to understand cancer-immune interactions in humans
PhD Defence
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Voila/Neuromet
To be able to identify, slow down and reverse functional deterioration in the elderly to give them more years of good health.
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Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
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The Rome Statute as Evidence of Customary International Law
On 9 April 2019, Yudan Tan defended her thesis 'The Rome Statute as Evidence of Customary International Law'. The doctoral research was supervised by Prof. dr. W.A. Schabas.
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Chemical tools to study lipid signaling
Synthesis and application of chemical biology tools to study immunomodulatory signaling lipids.
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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The road to insurmountability: Novel avenues to better target CC Chemokine receptors
This thesis explores different avenues to develop insurmountable antagonists for CC Chemokine Receptors, such as CCR1, CCR2 and CCR5.
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The role of the interleukin 12 family in atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-promotor: Saskia C.A. de Jager
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The serosa: an evolutionary novelty in insect eggs
What is the function of the insect serosa?
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Inverse electron demand Diels-Alder pyridazine elimination: synthetic tools for chemical immunology
The inverse electron demand Diels-Alder (IEDDA) pyridazine elimination emerged in 2013 as a new bioorthogonal reaction and constitutes a prime example of what is now known as dissociative bioorthogonal chemistry. The research described in this Thesis aims to develop synthetic strategies which enable…
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Host-Microbe Interactions
Host-Microbe Interactions is one of the four research themes of the Institute of Biology Leiden.
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Novel formulations and delivery strategies for inactivated polio vaccines: new routes with benefits
This thesis describes the development of improved formulations and alternative delivery strategies for polio vaccination.
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Mathematical Institute
The Mathematical Institute is responsible for the research and education in mathematics and statistics at Leiden University.
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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Chemical Synthesis of Fragments of Streptococcal Cell Wall Polysaccharides
This thesis describes the design and synthesis of fragments of various cell wall carbohydrates of the Streptococcus species, including the branched Group B-specific antigen (GBC) of Group B Streptococcus, glycerol phosphate (GroP) modified group A carbohydrate (GAC), and the O-acetylated type 1 capsular…
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Advanced in vitro models for studying drug induced toxicity
Promotor: Prof.dr. B. van de Water, Co-promotor: L.S. Price
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In vitro and in vivo evaluation of synergistic and opposing effects of Chinese herbal medicine and natural compounds on immuno-modulation.
Can we link multiple components from herbal extracts with their biological activities?
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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Civil Liability for Damage caused by Global Navigation Satellite System
On 17 December 2018, Dejian Kong defended his thesis 'Civil Liability for Damage caused by Global Navigation Satellite System'. The doctoral research was supervised by Prof. dr. P.M.J. Mendes de Leon.
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Supramolecular peptide amphiphile nanoparticles as a novel allergy vaccine platform
Bet v1, the major allergen in birch pollen, is one of the main causes of allergies such as asthma and rhino-conjunctivitis. Additionally it is the main cause of birch pollen allergy in humans.
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Development of an effective, safe, and painless intradermal tuberculosis vaccine based on microneedles loaded with antigen-containing nanoparticles
Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…
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Image-based Computational Biology
In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…
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Physics and Engineering Approaches to Biomedicine and Pharmacology
Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.
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Chemical Biology
Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…
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From islet transplants to stem cell therapy for diabetes patients
Stem cells can be differentiated into insulin-producing cells.
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Leiden University Medical Center
The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.
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Repair a bad kidney or make a new one to order
Searching for ways to delay the need for a transplant and trying to build kidneys to order.
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Research
Research at the BIOSYN group is comprised of the following research themes:
- IBL Symposium 2021
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Geometry in ornament: On the history, theory and science about the presumed universality of geometrical patterns and its cognitive foundation
Knowledge and culture subproject 3:
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Social and emotional competence in children and adolescents who are Deaf or Hard of Hearing (DHH)
How does having limited access to the social world affect Deaf or Hard of Hearing (DHH) children’s emotional development? And in turn, how do impairments in emotional functioning affect social development and the development of psychopathology?
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Development of the human fetal immune system: Novel insights from high-dimensional single-cell technologies
PhD Defence