PURPOSE: In the present study we investigated the root-cause of an interference signal (100-200 nm) of sugar-containing solutions in dynamic light scattering (DLS) and nanoparticle tracking analysis (NTA) and its consequences for the analysis of particles in biopharmaceutical drug products.

Promotor: M. Franx, Co-Promotor: I.F. Labbé

Promotor: Prof.dr. T. Schmidt, Co-promotor: Dr. ir. S. J.T. van Noort

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

Gold nanoparticles show surprisingly strong interactions with light in the visible range, which can be divided into scattering, absorption, and photoluminescence.

Promotor: M.T.M. Koper, Co-Promotor: F. Calle-Vallejo

The Executive Board has appointed Professor Harold Linnartz as Professor of Laboratory Physics with effect from 1 June 2011. Linnartz has worked since 2005 as senior lecturer at the Leiden Observatory.

Large areas of space are filled by molecular clouds that consist of gas and dust grains that are the remnants of dead stars. When these clouds start collapsing, the decreasing temperature and increasing density cause gas particles to start accreting onto dust grain surfaces.

An important award like the Spinoza Prize, the 'Dutch Nobel Prize', generates lots of media attention. An overview.

Students from the Coornhert Lyceum from Haarlem visited the Babylab Leiden together with their teacher Roos Bannenberg. The 5-VWO students follow modules of 10 weeks for science orientation and they had difficulty imagining what research with babies looks like. The Babylab Leiden gave a solution.

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

Astronomers want to understand the Universe, from the Big Bang to the present day, and what the future will hold. In Leiden they focus on two key questions: ‘How did stars and planets originate’ and ‘How were galaxies and black holes formed in the young Universe?’ A new generation of telescopes – just…

A remarkable population of short period transiting rocky exoplanets with equilibrium temperatures on the order of 2,000 K has recently been discovered.

Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

Galaxies form and evolve through close interaction with their surroundings. As a result, the heavy elements ('metals') that are synthesized in stars, are found both inside and outside galaxies.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

Lecture

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

Promotor: Prof.dr. M.A.G.J. Orrit

Promotor: M. Ubbink, Co-promotor: G. Siegal

Dr. in Biomedical NMR spectroscopy, LUMC, Leiden - The Netherlands

The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.

Twee teams of astronomers, including from the universities of Amsterdam and Leiden, have discovered how hot gas giants are surrounded by large halos of thin helium gas, an indication that they are slowly losing their atmosphere. The helium, that was recently seen for the first time by the Hubble space…

This thesis is a collection of experimental attempts to enhance photoluminescence of fluorescent molecules and quantum dots with single gold nanorods (GNRs) and relevant applications.

In this thesis, we use low-frequency and high-frequency radio observations to address the following questions regarding quasars: is the radio loud/quiet quasar dichotomy real?

This thesis discusses the physical and chemical processes than influence the composition of forming planets.

A full overview of MacBio PhD Theses.

The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…

Visualising cell proteins without invasive techniques is possible with the help of fluorescence. During a lecture of the Natuurwetenschappelijk Gezelschap Leiden on 18 January, winner of the Spinoza Prize 2017 and founder of the field of single molecule optics Michel Orrit explained how this works.

PhD Defence

PhD Defence

PhD Defence

Michel Orrit was awarded the Physica prize 2016 for his groundbreaking work on single molecule spectroscopy.

Bernhard Brandl, the new Leiden Professor of Infrared Astronomy, is developing instruments for the world’s largest telescopes. These telescopes can be used to observe objects in space that are more than 13 billion years old. Brandl will deliver his inaugural lecture on 26 September.

PhD Defence

PhD Defence

The van Exter group has an extensive history of prior research in classical and quantum optics. As former part of the group of Han Woerdman, we have studied topics as diverse as:

Promotor: C.U. Keller, Co-Promotor: F. Snik

Rottgering

These are the proposed research projects for LEAPS 2019. Please note that not all projects will go ahead and some may still be added in the near future. Final funding decisions lie with the Faculty sponsors. And please make a note that if you are interested in an ESA project, to check if your state…

On September 12, Michel Orrit received his Spinoza prize in the Royal Theatre in The Hague from OCW Secretary of State Sander Dekker. With the award comes a budget of 2.5 million euro, to be spent freely on scientific research, and the coveted Spinoza statue. Orrit shared the honor with Eveline Crone…

The main subject of this thesis is the design and synthesis of paramagnetic molecules for protein studies with NMR and EPR spectroscopy.

Our facilities cover: