106 search results for “inflammation” in the Public website
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B cell modulation in atherosclerosis
Cardiovascular disease is a major global burden and atherosclerosis is the main underlying pathological process.
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Inflammafish: Cross-talk between inflammation and autophagy in tuberculosis
Effective host defence against tuberculosis bacteria depends on a properly balanced level of inflammation. The Inflammafish project uses zebrafish larvae to study how autophagy controls this inflammation and vice versa.
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metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
Promotores: T. Hankemeier; R. Berger, Co-promotor: R.J. Vreeken
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Imaging of biomaterial-associated inflammation and infection using zebrafish
Which immune mechanisms are involved in host defense against Staphylococcal infection?
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Direct relationship between depression and inflammation called into question
Depression has traditionally been linked to increased inflammation. Innovative research by psychologist Eiko Fried refutes this popular assumption. He shows that specific depression symptoms such as sleeping problems explain this relationship. Publication in Psychological Medicine .
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Nanomedicine to Visualize and Treat Inflammation after Stroke (NAVISTROKE)
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Role of Chemokine Gradient Sensing in Ewing Sarcoma Progression, Angiogenesis and Immune Targeting
What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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correlates with the skin barrier function in atopic eczema patients and inflammation plays a role in the altered epidermal lipid biosynthesis
Source: Journal of Investigative Dermatology, Volume 135, pp. S59-S59 (2015)
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New substances inhibit inflammation in the brain
Chemical biologists from Leiden, led by Dr Mario van der Stelt, have discovered substances that can reduce inflammation processes in the brain. This is a first step in the development of potential medicines for the treatment of brain diseases like Alzheimer's and Parkinson's. Published in Proceedings…
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
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Conquering the fortress: New strategies for the treatment of tuberculosis
Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?
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The role of inflammation in muscle aging
PhD Defence
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Endothelial dysfunction and inflammation in diabetic nephropathy
PhD Defence
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TechTalk Autoimmunity & Inflammation
Lecture
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Cell therapy in ischemic heart disease models: role of inflammation and paracrine factors
PhD Defence
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The role of inflammation in cardiac and vascular remodelling
PhD Defence
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Ocular inflammation in age-related eye diseases
PhD Defence
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Systemic and adipose tissue inflammation in obesity and insulin resistance
PhD Defence
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Coagulopathy and blood abnormalities in cancer and inflammation
PhD Defence
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metabolic interactions: using metabolomics to probe oxidative stress, inflammation and systemic immunity
PhD Defence
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Aspects of methodology in assessing inflammation and damage in rheumatoid arthritis and axial spondyloarthritis
PhD Defence
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Challenging the cholinergic system: ageing, cognition & inflammation
PhD Defence
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Computer-aided techniques for assessment of MRI-detected inflammation for early identification of inflammatory arthritis
PhD Defence
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The contribution of metabolic and adipose tissue inflammation to non- alcoholic fatty liver disease
PhD Defence
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Modulation of the immune system for treatment of atherosclerosis
Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.
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A vaccine against thickened artery walls
Atherosclerosis (thickening of the artery wall) is the most common cause of heart attacks or strokes, and one of the most common causes of death in the western world. People with this condition have to take medicine all their lives, so a vaccine for atherosclerosis would be a breakthrough.
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Stress-induced modulation of the innate immune system in cardiovascular disease
Promotor: Prof.dr. J. Kuiper
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Medical Biochemistry
Medical Biochemistry is a section of the Leiden Institute of Chemistry at Leiden University. The section is headed by Prof. Dr. Hans Aerts.
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Therapeutic Immunomodulation
The Therapeutic Immunomodulation Group is led by Prof. Johan Kuiper. In this group we aim to identify novel immunologic targets and apply immunotherapy to inhibit or even prevent the development of atherosclerosis.
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Systems Pharmacology
The Systems Pharmacology group is headed by Prof. Piet Hein van der Graaf. Systems Pharmacology is the quantitative analysis of the dynamic interactions between drugs and a biological system to understand the behaviour of the system as a whole, as opposed to the behaviour of its individual constituents;…
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Liver X receptor: therapeutic targeting of common pathways in Psoriasis and Cardiovascular co-morbidities
Both psoriasis and atheroslcerosis are diseases characterized by a chronic and systemic inflammatory profile with local lipid disturbances that alter the barrier function of the skin (psoriasis) and cause the development of atherosclerotic plaques (atherosclerosis).
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The interplay between lipids and the immune system in atherosclerosis
Cardiovascular diseases are among the most frequent causes of death in the world. The main underlying pathology of cardiovascular diseases is the development of atherosclerosis in the medium and large-sized arteries.
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Marjolein Soethoudt
Cannabis-like synthetic drugs may inhibit pain and inflammation, but their development is hampered by insufficient knowledge about the cellular receptor in the human body that such drugs should activate. Marjolein Soethoudt focused her PhD research on this receptor. She developed better molecular tools…
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BSc Project Research Presentatie Annelies Vlaar, 19 januari @ 15:00, LUMC
Het project heeft plaats gevonden in de Gorter LUMC groep onder begeleiding van Dr. J.W.M. Beenakker en prof.dr.ir. T.H. Oosterkamp . De titel van de presentatie is:"Contribution of inflammation and fat infiltration to T2 ." De datum van de presentatie is vrijdag 19 januari om 15:00 in zaal 222 , C2,LUMC.…
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First-pass and systemic metabolism of cytochrome P450 3A substrates in neonates, infants, and children
Growth and development affect the metabolism of drugs administered to neonates, infants, and children.
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Novel Immune Cell-Based Therapies for Atherosclerosis
Promotor: Prof.dr. J. Kuiper, Co-Promotor: S.C.A. de Jager
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Cytochrome P450 3A-mediated first-pass and systemic drug metabolism in children
From descriptive to physiological models that can predict oral absorption and elimination of CYP3A substrates across the pediatric age range.
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A₃ adenosine receptor allosteric modulator induces an anti-inflammatory effect: in vivo studies and molecular mechanism of action
Source: Mediators Inflamm (2014)
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Prediction of the potency of mammalian cyclooxygenase inhibitors with ensemble proteochemometric modeling
Source: J Cheminform, Volume 7, Issue 1 (2015)
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
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Cellular therapy promising treatment for arteriosclerosis
Vanessa Frodermann, a PhD student at the Biopharmaceutical department of the Leiden Academic Centre for Drug Research, has discovered that arteriosclerosis could be inhibited by cellular therapy. Arteriosclerosis is one of the leading causes of the development of cardiovascular disease. Her PhD defence…
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Annemarie Meijer new training coordinator in European network
The new project INFLANET will train young scientists in Europe to become experts in inflammation research. Professor Annemarie Meijer from the Institute of Biology Leiden coordinates the training.
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Stressed brain, stressed heart?
Ilze Bot and Johan Kuiper have published in The Lancet: Study unveils how stress may increase risk of heart disease and stroke. Aso: The National Dutch newspaper 'NRC' has mentioned them in a column