Promotor: Prof.dr. A. P. IJzerman, Co-Promotor: Dr. L.H. Heitman

Our ability to learn and control movements is essential for engaging in goal-directed behaviour. From buttoning your shirt and driving a car, to cooking dinner and brushing your teeth -- our actions in daily life rely on this ability.

A multi-disciplinary approach to past lifestyles and cultural practices

What is the function of the insect serosa?

Can birds - like people- ‘see’ voices and learn how to sing by listening and watching?

Does the mineralocorticoid receptor play a role in the effects of cortisol and synthetic glucocorticoids on the immune response?

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

Cardiovascular diseases are the primary cause of death in the world with atherosclerosis as primary underlying cause.

Can drug screening for tuberculosis treatment be made more efficient?

1. What is the exact role of PIN proteins in PAT? 2. How is PIN polarity established, and how is it modulated by AGC kinase-mediated phosphorylation? 3. What is the role of the AGC kinase, as modulators of PAT, in translating environmental signals, such as gravity, light or mechanical stress, to plant…

Imagine that you have a chronic skin condition, characterized by red patches of itchy, scaly skin. You regularly notice people staring at your skin and sense their reluctance to shake your hand. Or imagine that you have Parkinson's Disease, causing your hands to tremble and making it difficult for you…

Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…

Heart patients who maintain a healthy lifestyle can start earning discounts at shops or for trips out. The Tergooi Hospital is the first in the Netherlands to introduce this unique method that was co-developed by the research group headed by Professor of Health Psychology Andrea Evers and the Leiden…

Inaugural Lecture

Lecture, History Brown Bag Seminar

Can we exploit the cell death machinery of the host to develop new host-directed anti-TB treatments?

We examine how soil inoculation influences aboveground organisms (i) directly, and indirectly via (ii) its effects on plant chemistry or volatile emission, or via (iii) mediating the effects of belowground pathogens on aboveground organisms via the shared plant.

Conference

Four scientists from the Faculty of Science will receive a grant of up to 50,000 euros in the Open Competition Domain Science - XS from science financier NWO. This category emphatically strives to encourage curiosity-driven and bold research involving a relatively quick analysis of a promising idea.…

Many dangerous diseases such as COVID-19, Ebola and Q fever have jumped from animals to humans. But it is not only because of these diseases that we should include animals in our health policy, but also because of their right to health, writes PhD candidate Joachim Nieuwland. PhD defence on 13 May.

With this thesis the PhD-candidate aims to enrich the body of evidence concerning the relation between stress and health, and the mediating role of (un)conscious perseverative cognitions, which is captured in the extended perseverative cognition hypothesis.

Utilization of plant-originated products as new antibiotics

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

No two pandemics are ever the same. The current coronavirus crisis, for instance, is clearly very different from the deadly plague outbreaks in the 14th and 15th centuries. Can historians learn anything from the coronavirus crisis? And what can we learn at the moment from historians? These are questions…

What are the biological and biophysical mechanisms that control chemokine gradient sensing and migration of immune, endothelial, and tumour cells in tumour development?

This year, two Leiden master students will be awarded a KNMP Student Award. Both Wisse van Os and Jip Linthorst will receive 1,000 euros from the Royal Dutch Pharmacists Association (KNMP) as a reward for their excellent study results, motivation and commitment.

Biological chemist Nathaniel Martin is going to test an alternative antibiotic that can combat common resistant bacteria such as MRSA. For this purpose, he will receive 350,000 euros from the NWO's NACTAR programme. ‘We want to know how safe and effective our antibiotic is in a realistic situation.’

The Horizon 2020 project ImageInLife has started on 1 January, followed by a kick-off meeting at the coordinating University of Montpellier at the end this month. This Marie Skłodowska-Curie training network brings together European groups that work on the imaging of vertebrates and offers fourteen…

When foreign matter enters our body, our immune system has to make a choice whether or not to go on the attack. There are times when the system goes wrong, and we end up with an illness or an allergic reaction. Researchers at LUMC are trying to steer the immune system. The dossier on Immunity, Infection…

Leiden University Medical Center (LUMC) and the Centre for Human Drug Research (CHDR) are taking part in the phase 2 clinical trial of Janssen Vaccines’ candidate coronavirus vaccine. The vaccine will be tested on 45 test participants in Leiden from 14 September onwards.

Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…

The current COVID-19 vaccination campaign involves injecting the vaccine into muscle tissue, but injecting a smaller amount of vaccine in the skin might also provide good protection. The #wakeuptocorona crowdfunding campaign has enabled Anna Roukens (LUMC) to examine the safety and efficacy of vaccination…

For the first time, research has been conducted on how the health of detained persons prior to their detention differs from that of non-detainees and to what extent health problems change over the period: from before and after their detention.

Leiden Biology student Lukas Kiefer has won the Unilever Research Prize 2018 for his research into efficient production of a new antibiotic. Kiefer: ‘I want to make biological medicines available to people in need.'

Genetically modified organisms (GMOs) could be useful allies in the fight against critical environmental problems. Could because the use of GMOs is strictly regulated at the moment. A Leiden student team is now trying to make these GMOs safer with the aid of an ingenious lock.

Research groups in the Biological & Soft Matter Programme unravel mechanisms in biological processes and develop novel bio-inspired soft materials.

PhD Defence

The predication of the effect (efficiency and toxicity) of a drug in a patient is very important in (i) clinical decision support and (ii) the development of novel drug treatments.

As a result of an increased life expectancy, more people suffer from chronic diseases and discomfort. Elderly patients may have multiple diseases simultaneously, with concomitant multiple medications.

Dr. Jessica Kiefte-de Jong and Dr. Thijs Bosker, both Assistant Professors at LUC, have been awarded by The Leiden University Fund (LUF).

The Department of Medical Microbiology of Leiden University Medical Centre (LUMC) will investigate the efficacy of a new experimental vaccine from the pharmaceutical company Jansen against the coronavirus. The research is being conducted in collaboration with the The Janssen Pharmaceutical Companies…

Cardiovascular disease is the leading cause of death worldwide.

PhD Defence

How can we extend the drug residence time to combat diseases more effectively?