1,312 search results for “infectious diseases” in the Public website
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Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
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Combatting infectious diseases; nanotechnology as a platform for rational vaccine design
Currently, several successful vaccines are available. However, for pathogens with a highly variable genetic composition, and for which serum IgG antibodies are not a useful correlate of protection, effective vaccines are yet to be developed.
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Two-pronged attack on infectious diseases
A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.
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Mapping of bacterial genomes to combat infectious diseases
Mapping of bacterial genomes to combat infectious diseases
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Development & Disease
Development & Disease is one of the four research themes of the Institute of Biology Leiden.
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Leiden iGEM team wants to build a kit to diagnose infectious diseases
Fourteen bachelor’s and master’s students are representing Leiden University in this year’s International Genetically Engineered Machine competition (iGEM). Their plan: to create a kit that can be used to quickly identify infectious diseases in case of an outbreak.
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Development & Disease in Animal Sciences
Animal Sciences’ contributions to the Development & Disease research theme include the mechanisms and evolution of embryonic development, the development of cognitive mechanisms, and animal models for understanding mechanisms of human disease.
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Bram Slütter
Science
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TechTalk: Infectious Diseases
Conference
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NeCEN
With the powerful electron microscopes at NeCEN we study abnormalities in cells of blood vessels in cardiovascular disease, the interaction between pathogens and hosts in infectious diseases, molecular processes that cause cancer and the interaction between drugs and target proteins. Drug development…
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Health and disease
Bone research provides plenty of detailed data about the health of a person or a group. This data is not only used to reconstruct the past but also to fight disease today.
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FishForPharma: Training network on zebrafish infection models for pharmaceutical screens
How can zebrafish models be used to gain a better understanding of host-pathogen interaction mechanisms and to screen new drugs for infectious disease treatment?
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Reversing cardiovascular diseases
How can the development of constrictions in the blood vessels be reversed?
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Leiden-Brazil Summer School on Data Science in Health and Disease
This summer course will stimulate international collaborations between students from Brazil and Leiden. The course will provide an introduction to the use of big data analysis in health and disease. The programme, including theory and practical modules, will focus on diverse hospital data, “omics data”…
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Coen van Hasselt
Science
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Annemarie Meijer
Science
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Human disturbance of ecosystems leads to increase in disease-transmitting mosquitoes
The changes that humans are making to the landscape are beneficial for mosquitoes that spread diseases such as Zika, chikungunya and dengue. This is what biologist Maarten Schrama and his colleagues write in the journal Nature Scientific Reports. ‘If we know in which living environments mosquitoes thrive…
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Herman Spaink
Science
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Immunity, Infection and Tolerance
The LUMC has a longstanding tradition researching the role of the immune system in infectious diseases, transplantation and auto-immune diseases.
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Institute for Chemical Immunology
Overkleeft
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Research in Africa reduces health spending and prevents diseases of affluence
Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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TRANSAUTOPHAGY: European network for multidisciplinary research and translation of autophagy knowledge
TRANSAUTOPHAGY is a European COST action to promote multidisciplinary research on autophagy and translation of knowledge to applications.
- Practical Information
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Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?
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Staphylomics: Identifying host factors involved in staphylococcal infection
How can Staphylococcus aureus bacteria subvert the host immune system?
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Autophagy and Lc3-associated phagocytosis in host defense against Salmonella
Control of infectious diseases poses continuous challenges for human health.
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Systems dermatology of inflammatory diseases
Inflammatory skin diseases such as psoriasis and atopic dermatitis can severely impact both the physical and social aspect of a patient’s life. Aberrant inflammatory responses are thought to be a major causative factor in these disorders, but an abundance of different factors contribute to the development…
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Inaugural lecture: Innate immunity into the picture
Tuberculosis bacteria and other intracellular pathogens use cells of our immune system as Trojan horses to spread into tissues. Annemarie Meijer, professor of immunobiology, explains how research into innate defence mechanisms using zebrafish inspires novel strategies for infectious disease treatmen…
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Personalized Medicine
Assessing and implementing new diagnostics strategies for stratifying patients
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NACTAR: The lugdunomycins: a new class of polyketide antibiotics with unique chemical scaffold
Aim of the proposal is to develop lugdunomycin into a drug candidate able to treat infectious diseases caused by multi-drug resistant pathogens.
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Cell Therapy
Decision support tool for cell therapy commercialization and business development
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glucosylceramide metabolism fundamental studies and applications for Gaucher disease
This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).
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Development & Disease in Microbial Sciences
Microbial Sciences'contribution to the Development & Disease research theme is to perform world-class research to understand cellular morphogenesis, growth, development and virulence of microbes.
- Facilities
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Chemokine signaling in Tuberculosis and Salmonella infection
Who benefits from CXCR/CXCL chemokine signaling during infection: host or pathogen?
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Development & Disease in Plant Sciences
Plant Sciences' contribution to the Development & Disease research theme is to unravel the processes that allow plants to adapt to changing abiotic and biotic environmental conditions or stresses, with the aim to contribute to the sustainable production of food, flowers and bio-based products using…
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Systems diagnosis of chronic diseases, explored by metabolomics and ultra-weak photon emission
Promotor: J. van der Greef; Co-promotor: E. van Wijk, M. Wang
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ZF-HEALTH - Zebrafish Regulomics for Human Health
How can zebrafish research help understanding human diseases?
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Magnetic Resonance Microimaging of Alzheimer's Disease
Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…
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Immunity, Infection and Tolerance
Our immune system protects us against disease, but every now and then, something goes wrong: an enemy invades our bodies or our immune system attacks our own cells and we become ill. Doctors and researchers at the Leiden University Medical Center (LUMC) want to be able to manipulate the immune system…
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metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
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Systems pharmacology of human neuroendocrine disease entities
An important hormone excreting gland in the human body is the pituitary
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Impaired barrier of inflammatory skin diseases
Focus in skin research
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Searching for disease indicators in healthy people
LUMC researchers are looking for factors that point to illness at an early stage.
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Macrophages as drivers of an opportunistic infection
The opportunistic bacterium Burkholderia cenocepacia is feared by cystic fibrosis patients and is emerging in hospital-acquired infections. An international study sheds new light on the infection mechanism of this opportunistic pathogen that may have large implications for treatment strategies.
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Circulating cells as biomarkers in cardiovascular disease : the difference between men and women
Promotor: J. Kuiper
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Japan
This is an Erasmus+ International Credit Mobility project of the Leiden University Medical Center with Nagasaki University.
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Better vaccines against malaria and tuberculosis
The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.