Promotores: W.J.G.M. Peijnenburg, G.R. de Snoo, Co-promotor: M.G. Vijver

Deficiency of glucocerebrosidase (GBA) underlies Gaucher disease, a common lysosomal storage disorder. Carriership for Gaucher disease has recently been identified as major risk for parkinsonism. Presently, no method exists to visualize active GBA molecules in situ. We here report the design, synthesis…

Lecture

A high-end label: Cyclophellitol aziridine-type activity-based probes allow for ultra-sensitive visualization of mammalian β-glucosidases (GBA1, GBA2, GBA3, and LPH) as well as several non-mammalian β-glucosidases (see picture). These probes offer new ways to study β-exoglucosidases, and configurational…

How can zebrafish research help to understand and fight human cancer?

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

Description of Development of a low cost technology for in-situ treatment of groundwater for potable and irrigation purposes (TiPOT) (2004 - 2007)

On 3 August Frederik Behre, PhD candidate at the Europa Institute, taught an international group of students and practitioners at the annual Summer School specialized in Information Technology Law organized by the Institute for Legal Informatics at the University of Hannover.

On 9 January 2019, Marieke Wierda defended her thesis 'The Local Impact of a Global Court: Assessing the Impact of the International Criminal Court in Situation Countries'. The doctoral research was supervised by Prof. dr. C. Stahn en Prof. dr. L.J. van den Herik.

'The World Upside Down. The Geographical Revolution in Humanist Commentaries on Pliny's Natural History and Mela's De situ orbis (140-1700)', in: Enenkel, K.A.E. & Nellen, H. (Eds.), Neo-Latin Commentaries and the Management of Knowledge in the Late Middle Ages and the Early Modern Period (1400-1700).Humanistica…

In surface science there is great effort to move from studying simple, flat model surfaces in vacuum to investigating more complex model catalysts in gas environments (in situ). This thesis gives three examples of such studies using microscopy and spectroscopy.

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Lecture

This project proposes an integrated and comparative study on the syntactic, semantic, prosodic and processing aspects of in-situ wh-questions, taking the Grammar-parser correspondence hypothesis (Phillips 1996, 2003) as a guiding principle.

The dissertation describes TEM experiments on heterogeneous catalysts.

Our facilities cover:

PhD Defence

Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.

Molecular complexes can be used as electrocatalysts for oxygen reduction, water oxidation, and/or hydrogen peroxide production.

The Saalian archaeological record at Maastricht-Belvédère (the Netherlands).

Dorothea Schulz & Martin Hense

PhD Defence

Promotor: Prof.dr. J.W.M. Frenken

The lysosomal β-glucosidase named glucocerebrosidase (GCase) is a retaining β-glucosidase that hydrolyzes the glycosphingolipid glucosylceramide (GlcCer) to ceramide and glucose at acid pH.

This thesis describes the design and development of subunit‐selective inhibitors of particular catalytically active subunits of human constitutive proteasomes and immunoproteasomes.

Promotor: J.W.M. Frenken

Pursuing Whiteness in the Colonies offers a new comprehension of colonial history from below by taking remnants of individual agencies from a whiteness studies perspective. It highlights the experiences and perceptions of colonisers and how they portrayed and re-interpreted their identities in Afric…

Key publications of the Skin Barrier and Vaccination group.

The End Of Our Fifth Decade. Corrie Bakels & Hans Kamermans (eds) (2012)

Promotores: G.A. Persoon, H.H. de Iongh

Overkleeft

The work described in this dissertation contributes to a better mechanistic understanding of nanoparticles in vivo. To achieve that goal, we used the zebrafish as a highly predictive pre-screening model of nanoparticles.

Bacterial chemosensory arrays are protein assemblies that are the key structural and functional component for motile bacteria to sense their internal or environmental chemical signals.

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Can metabolomic profiling be used to predict resistance against insect herbivores in plants?

Ecotox is a stimulating top-facility that provides an integrative research environment around the topic of ecotoxicological testing and experimental research. Research focus: Dose-response modelling Mode-of-actions and mechanism-of-actions Test method development, in view of targets in…

Crossing borders and connecting people in archaeological heritage management. Essays in honour of prof. Willem J.H. Willems

The nanoscale structure of a catalyst under reaction conditions determines its activity, selectivity, and stability. For the production of sustainable energy and materials, new catalysts are needed. By understanding the structure-activity relationships of catalysts under reaction conditions, insight…

Research at the Catalysis and Surface Chemistry group is comprised of the following research themes:

Are there acoustic cues for settlement stage larvae in deep-sea soundscapes around hydrothermal vents?

The

How has early development in R. ocellatus been modified as a result of its parasitic embryonic lifestyle?

Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.

Coordination chemistry is the chemistry of metal atoms