856 search results for “immunity infection and tol” in the Public website
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Tolerance and Immune Regulation in Rheumatoid Arthritis
PhD defence
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Novel mediators of anti-tumor immunity
PhD defence
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The Rome Hinterland Project
This project aims to integrate three of the largest survey databases in the Mediterranean to study the impact of the megalopolis Rome on its direct hinterland.
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Re-assessing the environmental impact of early Roman expansion
This project aims to explore the environmental impact of early Roman expansion (4th/3rd century BC) through a program of dating and ecological sampling of traces of field systems (centuriations).
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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Glucocorticoid modulation of the immune response
PhD defence
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Towards controlled microneedle-mediated intradermal immunization
PhD defence
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Synthetic carbohydrate ligands for immune receptors
PhD defence
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Identification of regulators of cancer - immune interactions
PhD defence
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New insights for improved pertussis vaccines - Press release -
Researchers in Bilthoven, The Netherlands, have recently unraveled the defense against whooping cough bacteria in unprecedented detail. The outcome of the project, conducted at Intravacc (Institute for Translational Vaccinology) in Bilthoven, provides opportunities for a new approach in the development…
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Improving therapeutic vaccines
Chemist Sander van Kasteren aims to accurately map how our immune system responds to vaccines, particularly those aimed at curing diseases like cancer and chronic viral infections. The goal is to use this knowledge to improve vaccine design. An ERC Consolidation Grant will provide him with the funding…
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Delivery of Biotherapeutics
The Delivery of Biotherapeutics research group is led by Prof. Matthias Barz and focusses on the synthesis and characterization of polypept(o)ids and their application in nanomedicine to improve existing therapies or enable novel diagnostic or therapeutic approaches.
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Leiden Spinoza and Stevin Prize laureates
Of the 105 Spinoza Prizes that have been awarded since 1995, 26 have gone to researchers from Leiden University. The NWO Spinoza Prize is the highest Dutch award in science. The younger NWO Stevin grant goes to researchers who have achieved great success in the field of knowledge utilisation for society.…
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Why Biomedical Sciences at Leiden University?
The Biomedical Sciences Master programme in Leiden will help to deepen and broaden your understanding of human health and disease. We provide you with a challenging and flexible programme in a personalized environment.
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Research
The Faculties of Leiden University have developed several themes for research cooperation between Leiden University and its Indonesian partners.
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Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
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Do common antibiotic treatments influence emotional processing?
People who have taken antibiotics in the past three months pay more attention to negative facial expressions, according to research by postdoc Katerina Johnson and assistant professor Laura Steenbergen. This may explain how antibiotics increase the risk of developing depression.
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European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
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Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
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Eduard Fosch-Villaronga & Louk van Doorn win the DT4REGIONS Ideathon on AI Potential for Preventive Healthcare
eLaw - Center of Law and Digital technologies from Leiden Law School, and the Vascular Surgery Department at Leiden University Medical Centre in the Netherlands, join forces to explore the use of AI for diabetes and secondary prevention of diabetic foot problems and won a prize for it.
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Immune Thrombocytopenia: Exploring antibodies, scintigraphy and immune modulation. Moving towards a new era for patients with ITP
PhD defence
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Unwiring beneficial functions and regulatory networks in the plant endosphere
How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?
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Individualized prognosis in childhood immune thrombocytopenia
PhD defence
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Projects
An overview of Quantitative Pharmacology projects
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Quest for new antibiotics
Gubbens
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Key publications
Key publications of the Biologics Formulation group
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Development of a universal delivery system for tailor-made cancer vaccines
The potential of liposomal cancer vaccines
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Host-Microbe Interactions in Animal Sciences
Animal Sciences’ contributions to the Host-Microbe Interactions research theme focus on the interaction of animal hosts with pathogenic microbes but also the beneficial role of the gut microbiome.
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Individualized dosing of serotherapy in allogeneic hematopoietic cell transplantation - a delicate balance
Promotor: C.A.J. Knibbe, Co-promotor: J.J. Boelens, R.G.M. Bredius
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Modulation of leukocyte homeostasis in atherosclerosis
Promotores: Prof.dr. E.A.L. Biessen, Prof.dr. T.J.C. van Berkel
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Bioorthogonal Labeling Tools to Study Pathogenic Intracellular Bacteria
In this thesis, bioorthogonal chemistry is combined with correlative light-electron microscopy to selectively label and study pathogenic intracellular bacteria within the host immune cell.
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Innovation in treatment and care
Treatment and care for cancer patients is becoming increasingly advanced. For example, surgeons can now perform operations with much greater precision, and therapeutic vaccines are being developed to prompt the patient’s immune system to fight cancer. Work is also being done on better early diagnostics,…
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Immunotherapy to limit atherosclerosis
Atherosclerosis is a chronic inflammatory disease, and vaccination may be an attractive method to induce long lasting protection against endogenous factors that contribute to the development of atherosclerosis. We have shown that for example vaccination against modified LDL or interleukin-12 limits…
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BK polyomavirus infection after kidney transplantation: risk and prevention
PhD defence
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Optimizing triage and treatment strategies in urinary tract infection
PhD defence
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Host-Directed Therapy for Intracellular Bacterial Infections
PhD defence
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Anti-glycan antibody responses during infection with Schistosoma
PhD defence
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Strategies in prevention and treatment of prosthetic joint infections
PhD defence
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Selective autophagy in host defense against mycobacterial infection
PhD defence
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Improving the treatment of pathogenic fungi. ‘The process is working, but not that well…’
Fungi germinating in the lungs of patients. Doesn’t sound too nice, does it? Luckily, humans can deal with this normally, and we are able to clear the infection before anything comes to harm. However, in people with health issues, Aspergillosis can cause a lot of damage, especially if the fungus becomes…
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Annemarie Meijer appointed full Professor of Immunobiology
Annemarie Meijer is appointed full Professor of Immunobiology. Meijer’s research focuses on immunobiology and infectious disease. She uses the zebrafish as a model for understanding mechanisms of host immune defense against intracellular bacterial pathogens.
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Characterization of innate immune cells in the glioma microenvironment
PhD defence
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T and NK cell immunity after hematopoietic stem cell transplantation
PhD defence
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Characterization of innate immune cells in the glioma microenvironment
PhD defence
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Neuropsychiatric symptoms and immune system parameters in Huntington's Disease
PhD defence
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Immune cell complexity in the tumor microenvironment of breast cancer
PhD defence
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Natural and Vaccine derived immunity against the human papillomavirus
PhD defence
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Immunochemical approaches to monitor and modulate the adaptive immune system
PhD defence