Dr. Foks obtained this fellowship for the project “Can promotion of efferocytosis induce regression of atherosclerosis?”, in which she aims to identify novel targets to promote regression of atherosclerosis. This research grant allows her to initiate independent research for the next three years.

As part of the HTSM2017 funding program, the LACDR division for Systems Biomedicine and Pharmacology received 1.08 million euros for a research project to develop novel engineering approaches to fight cancer.

Vitamin A or retinol is essential in embryonic development, the visual cycle and the immune system.

The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…

Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…

PhD defence

PhD defence

PhD defence

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

A coronavirus booster shot provides a better immune response against COVID-19 than a single vaccine dose. mRNA boosters are the most effective upon receiving Janssen. These are the results of a collaborative study between several organisations, including the Leiden University Medical Center (LUMC).…

Corneal transplantation is one of the most common human organ transplantations worldwide. Although the 1-year survival rate is as high as 90%, more than half of transplantation patients suffer various types of corneal rejection, such as epithelial rejection, chronic stromal rejection, and endothelial…

Lecturers had a week to move their courses online. An enormous challenge because remote teaching definitely wasn’t commonplace at Leiden University. Suzan Verberne, a lecturer and researcher at LIACS, shares her experiences. ‘I tried to do too much in my first week working from home.’

IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.

Promotores: Wim Jiskoot; Ferry Ossendorp

Vaccines are an extraordinary category of biopharmaceuticals. They are usually prophylactic and come in many types, from whole bacteria to peptides and nucleic acids. They are very cost effective and almost every human on the planet is vaccinated. The latter mandates that vaccines have to be extremely…

Hermelijn Smits is Professor of Host-commensal Interactions and Immune Modulation. In this role she is increasing our current understanding of the way in which microbes and parasites shape our immune system to protect us from respiratory infections and chronic inflammatory diseases. In her inaugural…

Leiden University and Leiden University Medical Center have joined the Netherlands Centre for One Health (NCOH), further strengthening the academic network in which such problems as antimicrobial resistance are studied.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

The Pontine Region Project (PRP) is an on-going archaeological project that aims to study the long-term history of settlement and landscape in the Pontine region

Science, Institute of Biology Leiden (IBL)

Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…

Physics and Engineering Approaches to Biomedicine and Pharmacology

Infecting each other with viruses and bacteria while protecting yourself with medicines and vaccinations. Sounds like a fun evening, right? Master students Life Science & Technology Rafael Jezior and Dennis de Beeld certainly think so. Together, they developed ImmunoWars: an exciting card game based…

Leiden chemists discovered a new mechanism which might explain how multiple sclerosis shifts to a more severe form. Their findings contribute to unravelling the mysterious course of the disease. They have published their findings in the journal Biochemistry.

The major aim is to determine the psychophysiological responses to stress and stress-management interventions and to examine the role of stress and stress-related psychophysiological mechanisms (e.g., cognitions, behaviors, and physiological stress responses) in both healthy and medical populations.

Despite the fact that gold nanoparticles (GNPs) are one of the most studied nanoparticles, there is still a necessity for new approaches allowing for effective protective coating to enable wider use of GNPs in biomedical applications.

The Leiden University Medical Center (LUMC) is committed to improving healthcare and the health of individuals. The LUMC staff put this mission into practice on a daily basis with their leading research, cutting-edge teaching and optimal, innovative healthcare.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Research at the BIOSYN group is comprised of the following research themes:

The word ¨pyroptosis¨ can be understood as ¨fiery falling¨, which describes the bursting of pro-inflammatory signals from the dying cell. Our observations indicate that pyroptosis also ¨spreads like wildfire¨ and once a cell dies via pyroptotic cell death, neighbouring cells are more prone to die as…

The Dutch empire fulfilled the goals, interests and necessities of the central state, of the local elites and of the common man. This thematic issue of Tijdschrift voor Geschiedenis goes beyond traditional views of the Empire as a ‘trading enterprise’, and argues that the Dutch empire, like all other…

This five year research project aimed to investigate the role of minor central places in the economy of Roman Central Italy.

In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.

A combination of two potential drugs gives hope of a 'super blockage' of an over-active immune system, Leiden researchers report in Nature. The breakthrough came from the crystallisation of a membrane protein.

Science, Institute of Biology Leiden (IBL)

Science, Institute of Biology Leiden (IBL)

Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…

Is it possible for sugar patterns on cells to activate the immune system to combat cancer?

In the Leiden University Medical Centre (LUMC) we strive to improve health care and the health of people.

PhD defence

Can we find and commercialise new treatments for chronic disease that affect our ageing population? And how can we customise this research and development programme to the small but highly-developed Netherlands research economy?