This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

PhD defence

Science, Institute of Biology Leiden (IBL)

This thesis is based on five papers on several topics.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

Systems pharmacology aims to apply techniques from systems biology to pharmacological models.

This thesis seeks to combine two different research topics; Multi-Objective Optimization and Complex Network Analysis.

Science

-

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

The Automated Design and Analysis of Algorithms (ADA) research group pursues the development of Artificial Intelligence techniques that complement, rather than replace, human intelligence.

A new research data infrastructure in computational social science

Promotor: Prof.dr. E. Deprettere

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

How does the cluster bootstrap procedure in combination with various types of linear models perform in the analysis of longitudinal data, compared to other methods.

A research goal for ABS is to develop miniaturized platforms for research in (stem)cell, in-vitro systems and application in clinical and preventive research. Combined with the high throughput, this development will make it possible to study the dynamics of pathogenesis in human and cellular models…

Can we develop a platform for raw materials intelligence?

Are you thinking about studying Cultural Analysis: Literature and Theory? Learn more and watch the videos.

This paper, written by Silvia D'Amato & Andrea Terlizzi, investigates the extent to which the European Union is strategically engaging against terrorism.

The aim of this project is to study what makes an act or form of violence a specifically political reality.

In Shimmering Images, Eliza Steinbock traces how cinema offers alternative ways to understand gender transitions through a specific aesthetics of change.

How do documentary moving images and fictional narratives involve and evolve each other?

How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?

Science is typically a patchwork of research contributions without much coordination. Especially in clinical trials, the follow-up studies that we do fail to be the most promising.

The master in Cultural Analysis: Literature and Theory at Leiden University focuses on the study of literature from a comparative and theoretical perspective, with a special emphasis on literary movements and genres of the 19th, 20th, and 21st centuries. It covers a wide range of languages and cultures…

Science, Mathematical Institute (MI)

Thanks to data science, we can chart and search enormous quantities of related information. This generates all kinds of new insights, for example in complex global financial structures or such societal problems as loneliness.

The most famous monument of the Dutch Golden Age is undoubtedly the Amsterdam Town Hall by architect Jacob van Campen inaugurated in 1655.

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

This project aims to improve understanding of, and responses to, the phenomenon of lone actors through analysis of comprehensive data on cases from across Europe.

This project aims to study the Aesopian fable from 1500 to the present day in its complex relationship between text, illustration and education, adopting a broad, transnational perspective.

Human and animal cells are very complex: very different chemical processes are going on at the same time, but they are separated from each other because the cells are divided in compartments. These compartments may also have a profound effect on the potential efficacy of therapeutics, because the drug…

Promotor: C.U. Keller, Co-Promotor: F. Snik

The wealth of shoes, sandals and other footwear from ancient Egypt is poorly understood due to lack of research. This is remarkable, because from the very beginning of Egypt’s long history footwear served practical as well as more spiritual purposes.

Science, Mathematical Institute (MI)

In meta-analysis, heterogeneity often exists between studies. In such cases, it is essential to investigate the sources of heterogeneity and understand the relationship between effect size and study characteristics (i.e., moderators).

Promotor: B. van de Water

D2.2 comprises the in-depth legal analysis of the initial heuristic model, focused on addressing, in more detail, the main legal concerns for data reusers in the European data economy. This detailed analysis of the legal propositions presented in D2.1 is supplemented by an analysis of the technological,…

The chemical and structural heterogeneity of toxoid vaccines makes their analysis challenging. However, detailed insights on a molecular level can be obtained by mass spectrometry.

-

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

Can we develop a generic method for Quan/Qual analysis of small molecule drugs, their metabolites and endogenous metabolites in (pre-)clinical samples?

Analytical tools for environmental design and management in a systems perspective. The combined use of analytical tools.

D1.2 reports on the findings of an analysis of framework conditions relevant in the context of the data economy from a legal, a socio-economic and a technological perspective. The analysis is a key foundation for the creation of an initial, heuristic model of the European data economy. The deliverable…

Promotors: W. Jiskoot; G.J. Witkamp, Co-promotor: M.R. Nejadnik

Supervisor: Gerard van Westen