1,141 search results for “humanized antibodies” in the Public website
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulations
Promotor: W. Jiskoot, Co-promotor: A. Hawe
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Predicting early Alzheimer's disease stage in human
A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).
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Writing the History of the Humanities: Questions, Themes, and Approaches
What are the humanities? As the cluster of disciplines historically grouped together as “humanities” has grown and diversified to include media studies and digital studies alongside philosophy, art history and musicology to name a few, the need to clearly define the field is pertinent.
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Hard power and the European Convention on Human Rights
On 18 June 2019, Peter Kempees defended his thesis 'Hard power and the European Convention on Human Rights'. The doctoral research was supervised by Prof. R.A. Lawson and Prof. H. Duffy.
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Fire use in human evolution: A genetic approach
Are traces of fire use detectable in ancient hominin genomes?
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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Information activities
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Epistemic Virtues in the Sciences and the Humanities
This book explores how physicists, astronomers, chemists, and historians in the late nineteenth and early twentieth centuries employed ‘epistemic virtues’ such as accuracy, objectivity, and intellectual courage. In doing so, it takes the first step in providing an integrated history of the sciences…
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Environmental Humanities in the New Himalayas: Symbiotic Indigeneity, Commoning, Sustainability
Environmental Humanities in the New Himalayas: Symbiotic Indigeneity, Commoning, Sustainability showcases how the eco-geological creativity of the earth is integrally woven into the landforms, cultures, and cosmovisions of modern Himalayan communities.
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Barrier properties of an N/TERT based human skin equivalent
Human skin equivalents (HSEs) can be a valuable tool to study aspects of human skin, including the skin barrier, or to perform chemical or toxicological screenings.
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Social decision making in humans and great apes
Efficiently responding to others’ emotions has great survival value, especially for social species, such as primates, who establish close, long-term bonds with group members. The closest living relatives to humans are the chimpanzee and the bonobo. Studying these species, and comparing them on the exact…
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Development of human skin equivalents to unravel the impaired skin barrier in atopic dermatitis skin
Promotor: J.A. Bouwstra Co-promotor: A. El Ghalbzouri
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Human skin equivalents for atopic dermatitis: investigating the role of filaggrin in the skin barrier
Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri
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Mini Symposium: Current AI Research at the Faculty of Humanities
Conference
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Ecology and conservation of spotted hyena in human dominated landscapes in northern Ethiopia
Promotors: Prof.dr. G.R. de Snoo, Prof.dr. H. Leirs (Univ. Antwerpen), Co-promotor: H.H. de Iongh
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Proving discriminatory violence at the European Court of Human Rights
On Tuesday 23 May 2017, Jasmina Mackic defended her doctoral thesis ‘Proving discriminatory violence at the European Court of Human Rights’. The supervisor of the research is Vice Dean and Professor of Public International Law Larissa van den Herik. A brief summary of her thesis is provided below.
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European and International Human Rights Law (Advanced LL.M.)
Are you thinking about studying European and International Human Rights Law? Learn more and watch the videos.
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Microengineered Human Blood Vessels For Next Generation Drug Discovery
Heart failure is a major health care problem with high mortality.
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The future of AI is human
From self-driving cars to innovative drug development: artificial intelligence (AI) will fundamentally change our lives in many different ways. We study this technology at a deep and fundamental level. And we seek answers to questions about liability and privacy, for example. Our researchers from…
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Catecholamine function, brain state dynamics, and human cognition
The work presented in this thesis addresses the role of the locus coeruleus (LC) - norepinephrine (NE) system in various aspects of human cognition, and the modulation of brain state.
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Force sensing and transmission in human induced pluripotent stem-cell-derived pericytes
Pericytes, the mural cells of blood microvessels, are important regulators of vascular morphogenesis and function that have been postulated to mechanically control microvascular diameter through as yet unknown mechanisms.
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Child Marriage as a Choice. Rethinking agency in international human rights
On 18 March 2020, Hoko Horii defended her thesis ‘Child Marriage as a Choice. Rethinking agency in international human rights’. The doctoral research was supervised by prof. A.W. Bedner and prof. G.A. van Klinken.
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cold: The adaptive role of pyrotechnology among the earliest modern humans in Europe, ca. 45,000–20,000 years ago
The routine assumption that Upper Palaeolithic early modern humans in Europe were regular fire users who produced fire at will has never been tested against the archaeological record. Utilizing literature, database and microwear analytical approaches, this project seeks to establish the role and forms…
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Benjamin’s Figures: Dialogues on the Vocation of the Humanities
The writings of Walter Benjamin (1892-1940) are famously and purposely marked by fragmentariness. Paradoxically, a central aim of his work was to connect: all his life he sought to further the integration of scholarship in the humanities which, he believed, had too long suffered from the prevalence…
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The right to family unification : between migration control and human rights
The central question in this book is whether there is a human right to family unification.
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based toxicity assessment: towards quantitative risk prediction in humans
Promotor: Prof.dr. M. Danhof, Co-promotor: O.E. Della Pasqua
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Human epidermal lipid biosynthesis in health and disease
How are the epidermal lipid pathways involved in health and disease.
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Innovative strategies to clinically characterize the human tear proteome
Transplantation of labial salivary glands to the eyelids for patients with dry eye appears to give excellent results clinically.
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Online Master’s Experience European and International Human Rights Law
Study information, Online Master’s Experience
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Exploring the potentials of nurture: 2(nd) and 3(rd) generation explant human skin equivalents
BACKGROUND: Explant human skin equivalents (Ex-HSEs) can be generated by placing a 4mm skin biopsy onto a dermal equivalent. The keratinocytes migrate from the biopsy onto the dermal equivalent, differentiate and form the epidermis of 1(st) generation Ex-HSEs. This is especially suitable for the expansion…
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How Bio-questionable are the Different Recombinant Human Erythropoietin Copy Products in Thailand?
The high prevalence of pure red cell aplasia in Thailand has been associated with the sharp increase in number of recombinant human erythropoietin (rhEPO) copy products, based on a classical generic regulatory pathway, which have entered the market.
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PhD Position in the Virtual Human for Safety (VHP4Safety) Project
Science, Leiden Academic Centre for Drug Research (LACDR)
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Comparative ecology and genetics of sympatric wild cats in relation to human wildlife conflict in Bardia National Park, Nepal
What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…
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Formulation of influenza T cell peptides: In search of a universal influenza vaccine
Promotoren: G.F.A. Kersten, W. Jiskoot, Co-promotor: J-P. Amorij
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Intracellular allosteric modulators for human CC chemokine receptors
Supervisor: Natalia Ortiz Zacarías
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Chemical tools to monitor and control human proteasome activities
Promotores: H.S. Overkleeft; G.A. van der Marel Co-Promotor: B.I. Florea
- Teaching Social Sciences and Humanities in Secondary Education (MA)
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Human-lion conflict around Nairobi National Park: Lion Population Structure, Diet, and Movement in a Semi-Fenced Park.
What is the population size and social structure in time and space? What is the lion diet and food preference in time and space? What is the home range (MCP and Kernel) and movement in time and space? What are human – lion conflict and responses of lions to traditional herding in time and space? What…
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Clinical Glycomics of Antibodies by Mass Spectrometry
PhD defence
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The Fate of Freedom Elsewhere. Human Rights and U.S. Cold War Policy
This is the 2017 paperback release of William Michael Schmidli's The Fate of Freedom Elsewhere, which won the 2013 Foreign Affairs Magazine Best Book of the Year.
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An ex vivo human skin model for studying skin barrier repair
In the studies described in this study, we introduce a novel ex vivo human skin barrier repair model. To develop this, we removed the upper layer of the skin, the stratum corneum (SC) by a reproducible cyanoacrylate stripping technique.
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JLGC 08: Animals (Un)tamed: Human-Animal Encounters in Science, Art, and Literature
The eighth issue of the JLGC explores the diverse and interdisciplinary research on our multifaceted relationship with animals which is currently taking place, re-examining the relationship between humans and animals, and the definitions involved.
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Ecology of the Ethiopian wolf in a changing landscape: Human carnivore interactions in Afroalpine ecosystems of Ethiopia
Do Ethiopian wolves change their diet and foraging strategy in the landscape under different land uses? How land use affect Afro-alpine rodent Communities? How important are Afro-alpine natural resources utilisation for local livelihoods? What is the human perception of conflict in the Afro-alpine a…
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Freedom on the Offensive: Human Rights, Democracy Promotion, and US Interventionism in the Late Cold War
In Freedom on the Offensive, William Michael Schmidli illuminates how the Reagan administration's embrace of democracy promotion was a defining development in US foreign relations in the late twentieth century.
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Human nature and governance: soulcraft and statecraft in eleventh century China
On the 2nd of September Jiyan Qiao successfully defended a doctoral thesis and graduated.
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Human Security and Conflict in Ukraine: Local Approaches and Transnational Dimensions
The project investigates the implementation of policies and practices related to reconciliation and the strengthening of government capacity in the Odesa and Kharkiv regions of Ukraine.
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pharmacokinetic models to the prediction of local CNS drug concentrations in human
Clinical development of drugs for central nervous system (CNS) disorders has been particularly challenging and still suffers from high attrition rates.
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Spatio-temporal dimensions of human-carnivore interactions in Chitwan National Park, Nepal
This is a joint PhD of the Faculty of Social and Behavioral Sciences at Leiden University and the Evolutionary Ecology Group at Antwerp University.
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Next generation human IPSC-derived reporter systems for image-based analysis of drug adversity
Analysis of drug adversity
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culture medium based approach to optimize the stratum corneum barrier of human skin equivalents
uman skin equivalents (HSEs) are in vitro 3D-skin models that mimic many aspects of the native human skin (NHS) and can be a valuable tool.