349 search results for “hospital-acquired infections” in the Public website
-
The quest for new medicines against tuberculosis
Can drug screening for tuberculosis treatment be made more efficient?
-
Research in Africa reduces health spending and prevents diseases of affluence
Health workers have always sought ways to fight disease in vulnerable groups in the population. It is now clear that such research also benefits more prosperous countries. African worm infections and innovative thermometers have shown Leiden researchers how to fight diseases of affluence and keep health…
-
Anti-microbial and Anti-biofilm compounds From Indonesian Medicinal Plants
Promotor: C.A.M.J.J. van den Hondel, Co-promotor: Sandra de Weert
-
Mycobacterial cell wall-deficiency and its role in the persistence of tuberculosis
What is the role of cell wall-deficiency in the persistence of tuberculosis?
-
Immunoproteomic Profiling of Bordetella pertussis Outer Membrane Vesicle Vaccine Reveals Broad and Balanced Humoral Immunogenicity
The current resurgence of whooping cough is alarming, and improved pertussis vaccines are thought to offer a solution. Outer membrane vesicle vaccines (omvPV) are potential vaccine candidates, but omvPV-induced humoral responses have not yet been characterized in detail.
-
Animal Sciences
We perform multidisciplinary research at molecular, cellular, and organismal levels of animal biology to increase fundamental understanding of health and disease.
-
Glucocorticoid modulation of the immune response
Unraveling the immune-suppressive actions of drugs like prednisone.
-
IFITMs – Nature’s weapon against viral infections
Lecture
-
Efficient and flexible platform to isolate and study bacteriophages
We aim to develop a microfluidic platform that can parallelize testing the performance and characteristics of pure, mixed and environmental bacteriophage samples.
-
Developing systems for high-throughput screening of infectious diseases using zebrafish
Promotor: Prof.dr. H.P. Spaink, Co-promotor: Prof. dr. A.H. Meijer
-
Innate immune defence against intracellular pathogens
What are the host immune defence mechanisms that control intracellular infections and how are these subverted by pathogens?
-
European Lead Factory
The European Lead Factory has been created with the ultimate goal to develop lead drug candidates to address neglected diseases including bacterial infections, psychiatric disorders and oncology.
-
Individualized dosing of aminoglycosides and glycopeptide antibiotics in (morbidly) obese patients (AMIGO)
Timely, adequate and optimal treatment of infectious diseases is essential for the survival of patients with bacterial infections (Surviving Sepsis campaign).
-
Chitin in the fungal cell wall: towards valorization of spent biomass of Aspergillus niger
Aspergillus niger is an important industrial producer of organic acids and enzymes producing large amounts of spent fungal biomass.
-
Functional analysis of agrobacterium tumefaciens virulence protein VirD5
Supervisor: P.J.J. Hooykaas
- Contact
-
Unwiring beneficial functions and regulatory networks in the plant endosphere
How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?
-
Influenza T-cell epitope-loaded virosomes adjuvanted with CpG as a potential influenza vaccine
Influenza CD8(+) T-cell epitopes are conserved amongst influenza strains and can be recognized by influenza-specific cytotoxic T-cells (CTLs), which can rapidly clear infected cells. An influenza peptide vaccine that elicits these CTLs would therefore be an alternative to current influenza vaccines,…
-
Quantitative Pharmacology
The Quantitative Pharmacology group headed by Coen van Hasselt focusses on the application of state-of-the-art quantitative pharmacological mathematical and statistical (pharmacometrics) modeling combined with systems biology modeling approaches, to characterize biomarkers for of disease and treatment…
-
Worm and stomach bacteria: our allies in the battle against allergic asthma
Parasitic worms and stomach bacteria suppress immune reactions such as allergic responses. Parasitologist Hermelijn Smits and lung specialist Christian Taube from the LUMC are trying to learn from these micro-organisms.
-
Quest for new antibiotics
Gubbens
- Treatment duration and prognostics in febrile urinary tract infection
-
LUMC involved in development of novel drugs to treat and prevent SARS-CoV-2 and other coronaviruses
The Department of Medical Microbiology at Leiden University Medical Center (LUMC) is researching antiviral drugs that could treat and prevent SARS-CoV-2 in various projects. One part of the PanCoroNed project is being led by Martijn van Hemert and involves lab tests into the antiviral effect of molecules…
-
Strategies in prevention and treatment of prosthetic joint infections
PhD Defence
-
Anti-glycan antibody responses during infection with Schistosoma
PhD Defence
-
Optimizing triage and treatment strategies in urinary tract infection
PhD Defence
-
Host-Directed Therapy for Intracellular Bacterial Infections
PhD Defence
-
BK polyomavirus infection after kidney transplantation: risk and prevention
PhD Defence
-
Hypoxic Signalling and Tuberculosis
IBL-researcher Phil Elks in the group of Annemarie Meijer won the Cell Observatory Publication of the Year 2013. He received the award for his paper in PLoS Pathogens, showing that activation of hypoxia signaling protects against mycobacterial infection.
-
Consequences of congenital cytomegalovirus infection in early childhood
PhD Defence
-
Mechanisms of immune evasion in Epstein-Barr virus infection
PhD Defence
-
Selective autophagy in host defense against mycobacterial infection
PhD Defence
-
Brazil, Guilherme Henriques
How do our Leiden alumni cope with the restrictive measures in their country, the possible finding of a vaccine, medication to combat corona or how do they cope with working from home, with or without children? Read the story of Guilherme Dias Henriques (Latin American Studies, 2019), living in B…
-
VARIS
When does it rain when air is oversaturated with moisture? How does an infection spread among the population? The problems that mathematician Professor Frank den Hollander tries to solve come from physics, chemistry and biology.
- Opening hours
-
ImageInLife: Training European experts in multilevel bioimaging, analysis and modelling of vertebrate development
How can novel bioimaging technologies and vertebrate model species be used to gain a better understanding of early cellular behaviours with the ultimate goal to increase our understanding of human development and disease processes?
-
Better vaccines against malaria and tuberculosis
The infectious diseases malaria and tuberculosis are responsible for 2.1 million deaths every year. Leiden researchers are currently testing a new tuberculosis vaccine.
-
Key publications
Key publications of the Quantitative Pharmacology group
-
Biology Lecture: Carbohydrate-binding Proteins as Targets for Anti-Infectives and Diagnostics
Lecture
-
Mechanisms underlying the resistance of Human papillomavirus- infected or -transformed cells to Th1 immunity
PhD Defence
-
Chemokine signaling mechanisms underlying inflammation and infection control: insights from the zebrafish model
PhD Defence
-
New strategies for the prevention and treatment of burn wound infections
PhD Defence
-
Pathogenesis of congenital cytomegalovirus infection: finding prognostic markers and correlates of protection
PhD Defence
-
Epidemiology of Clostridium difficile infections in the Netherlands and Europe: implications for surveillance and control
PhD Defence
-
Respiratory tract infection: prevention, early detection and attenuation of immune response
PhD Defence
-
respiratory viruses and insight in clinical implications of rhinovirus infections
PhD Defence
-
trichodysplasia spinulosa-associated polyomavirus; Discovery, Prevalence, Infection and Expression
PhD Defence
-
Parasitic Infections during Pregnancy in Gabon: Birth outcomes and immunological changes
PhD Defence
-
Plasmodium falciparum sporozoites in the controlled human malaria infection model
PhD Defence
-
Synthetic biology and genomics platform for new-to-nature bioactive peptides
Can the venom of snakes, scorpions and other animals be sources of new antibiotics?