57 search results for “hollow microneedles” in the Public website
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
In summary, the collective results described in this thesis show that nanoparticulate vaccines can be delivered intradermally by coated and hollow microneedles and evoke antigen-specific immune responses.
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Transcutaneous vaccination by means of coated and hollow microneedles
Transcutaneous vaccination is attractive because it is non- or minimally invasive, pain free and the site of administration (skin) is easily accessible. What’s more, transcutaneous immunization can lead to a strong immune response owing to the presence of immune-competent cells in the skin.
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Novel Hollow Microneedle Technology for Depth-Controlled Microinjection-Mediated Dermal Vaccination: A Study with Polio Vaccine in Rats
PURPOSE: The aim of the study was to develop a cheap and fast method to produce hollow microneedles and an applicator for injecting vaccines into the skin at a pre-defined depth and test the applicability of the system for dermal polio vaccination.
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Towards controlled microneedle-mediated intradermal immunization
Traditionally, vaccines are administered intramuscularly using conventional hypodermic needles, which cause pain and distress. Microneedles are very short needles (smaller than 1 mm) that are practically invisible to the naked eye.
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Microneedle-mediated vaccine delivery
Promotores: Prof.dr. J. A. Bouwstra, Prof.dr. W. Jiskoot
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Microneedle-based drug and vaccine delivery via nanoporous microneedle arrays
In the literature, several types of microneedles have been extensively described. However, porous microneedle arrays only received minimal attention. Hence, only little is known about drug delivery via these microneedles. However, porous microneedle arrays may have potential for future microneedle-based…
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Parameter optimization toward optimal microneedle-based dermal vaccination
Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.
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Tiny, pain-free vaccinations: microneedles and nanoparticles
If it’s up to PhD student Guangsheng Du, patients don’t need to worry about big needles anymore. At the Leiden Academic Center for Drug Research (LACDR), he studied the use of microneedles and nanoparticles as a new vaccination system. ‘I want to create a more patient-friendly delivery method.’ He defends…
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
Dissolving microneedles are a subgroup of microneedle types that completely dissolve within the skin. During this dissolving process the vaccine, stored in the needle matrix, is released into the skin.
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Monitoring the penetration process of single microneedles with varying tip diameters
Microneedles represent promising tools for delivery of drugs to the skin. However, before these microneedles can be used in clinical practice, it is essential to understand the process of skin penetration by these microneedles.
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Design of dissolvable microneedles for intradermal TB vaccination
Tuberculosis is an infectious disease which is spreaded through the air. It is caused by Mycobacterium tuberculosis and it led 1.7 million people to death in 2016. This mortarlity rate is concentrated in developing countries such as Indonesia, Philippines, Pakistan, and South Africa. These numbers make…
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Ovalbumin coated pH-sensitive microneedle arrays effectively induce ovalbumin-specific antibody and T-cell responses in mice
The aim of this work was to study the applicability of antigen-coated pH-sensitive microneedle arrays for effective vaccination strategies. Therefore, a model antigen (ovalbumin) was coated onto pH-sensitive (pyridine-modified) microneedle arrays to test pH-triggered antigen release by applying the…
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Intradermal delivery of nanoparticulate vaccines using coated and hollow microneedles
PhD Defence
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Key publications
Key publications of the Skin Barrier and Vaccination group.
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Impact-Insertion Applicator Improves Reliability of Skin Penetration by Solid Microneedle Arrays
Source: The AAPS journal, Volume 16, Issue 4, pp. 681-684 (2014)
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Research lines
Current research at the Skin Barrier and Vaccination group.
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effective, safe, and painless intradermal tuberculosis vaccine based on microneedles loaded with antigen-containing nanoparticles
Tuberculosis (TB) is a major global health problem caused by the bacterium Mycobacterium tuberculosis (Mtb). In 2015, there were estimated to be 10.4 million new cases and 1.8 million deaths ascribed to TB, making it one of the top 10 causes of death worldwide. Unfortunately, the only current registered…
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of an intradermal tuberculosis vaccine by combining dissolvable microneedle arrays and Mycobacterium tuberculosis antigen-containing nanoparticles
Mycobacterium tuberculosis (Mtb), the pathogen causing tuberculosis (TB), is the leader among all pathogens responsible for the most human deaths today and it is considered as one of the top 10 causes of death worldwide. There is an increasing occurrence of multidrug-resistant and even totally drug-resistant…
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Skin Barrier and Vaccination
The Skin Barrier and Vaccination group is led by Prof. Joke Bouwstra. One of the key functions of the skin is its barrier function, which is located in the uppermost layer of the skin, the stratum corneum. The stratum corneum consists of enucleated dead cells (corneocytes) embedded in a lipid matrix.…
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One step closer to pain-free vaccinations
Microneedles are a promising tool for the painless administration of vaccines through the skin. But, are these minuscule needles really effective? PhD student Pim Schipper of the Leiden Academic Centre for Drug Research investigated various factors of vaccination via the skin and discovered, among other…
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Third prize awarded to Pim Schipper for oral presentation at GPEN conference
Pim Schipper has won the third prize for his oral presentation during the tenth biennial meeting of the Globalization of Pharmaceutics Education Network (GPEN), which was held from 27 – 30 Aug 2014 at the University of Helsinki, Finland.
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Replacing the needle and syringe for vaccine administration
Promotores: Prof.dr. G.F.A Kersten, Prof dr. J.A. Bouwstra
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Mesoporous silica nanoparticle-based protein delivery systems for biomedical applications
Promotor: A. Kros
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Microfluidics for high-throughput liposome formulation for personalized cancer vaccination
Liposomes hold great promise for peptide-based personalized cancer vaccination, especially when administered intradermally. However, current liposome preparation methods are very time consuming (resulting in long development times per formulation), whereas personalized cancer vaccination requires very…
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Towards controlled microneedle-mediated intradermal immunization
PhD Defence
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Overview
Our research is aimed at a smoother and speedier transition from preclinical research to pharmacological interventions, and the delivery of drugs in the human body by use of small molecules and biologics.
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Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
- Summitry
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Development of hyaluronan-based dissolving microneedle arrays for dermal vaccination
PhD Defence
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Vaccine delivery
Vaccination via the skin or the mucosae
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The unexpected norm-setters: Intelligence agencies in cyberspace
Ilina Georgieva published an article in the journal Contemporary Security Policy on the norm-setting role of intelligence agencies.
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By Heritage Quest
Read all papers and other types of publication created by the project.
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Why Leiden University?
We are committed to provide you with meaningful, rigorous and quality graduate experiences in a personalized environment with a cutting edge research infrastructure and internationally renowned supervisors.
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Research
The research conducted at the Leiden Academic Centre for Drug Research is clustered within the divisions of BioTherapeutics, Drug Discovery & Safety and Systems Biomedicine and Pharmacology.
- Health Diplomacy
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The Wellness Track
These workshops are designed to help you take good care of yourself. They have been organised by LUC's SLO, Lenore Todd, in collaboration with experts on well-being. These workshops give priority access to current LUC students and are completely free of charge.
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Building with flexible blocks
On an apparently normal cube a pattern of hollows and bulges appears when the cube is compressed. A method has been developed to design such three-dimensional structures and to construct these using simple building blocks. Publication in Nature.
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A new building block for the quantum computer
The race to build the first quantum computer is still ongoing, but Morten Bakker has made big step forward in that process with qubits. A qubit is a unit of quantum information that can be produced in large numbers on chips. Qubits capable of exchanging photons (light particles) could be used in the…
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New technique to study vascular growth
Sonja Boas developed new techniques to study vascular growth computationally. The results of her research provide a better understanding into mechanisms behind vascular growth, which is relevant to the development of medical therapies. She defends her thesis 'Computational modeling of angiogenesis'…
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Forum Essays
Forum essays provide a framework for intellectual exchange and debate about the role of diplomacy around a particular theme. The essays are argumentative contributions and are shorter than research articles.
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Podcast #7 | Tristen Naylor on Diplomatic Summits and Meetings During (and after) COVID
The Hague Journal of Diplomacy is delighted to announce it will be starting its own podcast series! The series will be aimed at bringing the themes of the journal’s research off the page, and onto the discussion table. Each episode will feature a guest who will share their insights and personal experience…
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How can you rescue clay tablets from the war in Syria?
On 7 June, the National Museum of Antiquities opened a mini exhibition 'Scanning for Syria'. The exhibition shows how Leiden archaeologists and Delft technical specialists make reconstructions of 3000-year-old Assyrian clay tablets. The originals, stored in museum depots in Raqqa (Syria), have been…
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Olaf van Vliet and Lars van Doorn receive 430,000 euros grant for research
Researchers from the Department of Economics and the Institute of Public Administration – Olaf van Vliet and Lars van Doorn – have been awarded a grant of 430,000 euros from Instituut Gak to analyse the flexibilisation of the labour market and its implications for social policy.
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Discoverer of the Year, Best Dissertation and Education prize 2015
During the Faculty of Science New Year's reception, Daniël Rozen was named Discoverer of the year 2015. Nienke van der Marel and Koen van der Maaden both won the prize for the best dissertation and Jeroen van Smeden was named Best Teacher of 2015.
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The underwater Hobbit – a new shrimp species
‘In a hole under water there lived a hobbit’: a new species of shrimp named after Bilbo Baggings. Biology student Werner de Gier described this newly discovered species during his bachelor internship at Naturalis Biodiversity Center.
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Online exhibition
TEXTS FROM ANCIENT EGYPT. Highlights from the Collection of the Leiden Papyrological Institute. Online exhibition on the occasion of the 80th anniversary of the foundation ‘Het Leids Papyrologisch Instituut’ in 2015.
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Awards and Grants 2018
An overview of awards and prizes granted to our staff and students in 2018, as well as special appointments and royal distinctions.
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The eighty-year-old Leiden Papyrological Insitute has a small but great collection
The Leiden Papyrological Institute celebrated its eightieth birthday on Monday 19 January. Its collection of papyri – including paper, potsherds, pieces of wood and even lead – covers the period from 300 B.C. until after 800 A.D. and is entirely of Egyptian origin. The institute’s anniversary is being…
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Computational modeling of angiogenesis: from matrix invasion to lumen formation
PhD Defence
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CSPPR Opening Lecture, 5 October 2016
Lecture