To study how planetary systems come into existence we study much younger systems still in formation.

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

This thesis aims to demonstrate how the achromatic nature and design flexibility of liquid-crystal optics can be used to improve high-contrast imaging instruments to facilitate detailed exoplanet characterization.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

One of the key limitations of the direct imaging of exoplanets at small angular separations are quasi-static speckles that originate from evolving non-common path aberrations (NCPA) to which the primary adaptive optics system is inherently blind. The main focus of this thesis is the development and…

Promotor: Prof. dr. I. Snellen, Co-Promotor: Dr. M. Kenworthy

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

PhD defence

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

In this project we develop algorithms to automatically detect a particular type of archaeological sites in satellite images of the Alps.

PhD defence

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Double Bind. Public service professionals coping with contrasting demands. How do public service professionals align their PSM with contrasting demands set by the organizational and social contexts in which they work?

The imaging group focuses on bio-imaging, image analysis and visualization.

PhD defence

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

A computer can look at, and learn from, many more images than a human specialist. AI systems are rapidly becoming indispensable for medical and biological applications. But they still have to learn how to explain their decisions.

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Even though more than 4000 extra-solar planets are known today, only a small fraction of these has been captured in an image. To better understand the planet formation mechanisms in solar-like environments we started the Young Suns Exoplanet Survey (YSES).

This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Promotor: M.A.G.J. Orrit

Promotores: S.J. Edixhoven, P.Parent

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Obtaining imaging data is nowadays only the start of your project. Once the data has been acquired there are many things that still need to be done.

Promotor: C.U. Keller, Co-Promotor: F. Snik

This page is under construction.

PLATO is a centre for research and development in education and training. 4 areas of expertise and 4 methods.

Which immune mechanisms are involved in host defense against Staphylococcal infection?

The thesis introduces three methods for high-dimensional prediction problems in the biomedical field. The methods make use of empirical and variational Bayes in the estimation.

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

How and to what extent the historic house (re-)constructs identity through image-making in China.

This thesis focuses on the study of transient and variable radio sources in the universe.

This thesis mainly focuses on cross-modal retrieval and single-modal image retrieval via deep learning methods, i.e. by using deep convolutional neural networks.

PhD defence

A high performance computer or supercomputer owes its massive processing capacity to the fact that it chops a single overarching task into a whole series of smaller tasks. It simultaneously tackles each of those smaller problems.

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

One of the ways of understanding another culture better is to examine what people experience when they read a text, or look at an image. Leiden experts have a lot of knowledge in this field, for example on culture in ancient Japan.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

High Performance Computing previously the domain of theoretical scientists and computer and software developers is becoming ever more important as a research tool in many research areas. A University facility, providing serious computational capabilities, combined with easy and flexible local access,…

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek