To study how planetary systems come into existence we study much younger systems still in formation.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

The field of exoplanet research is rapidly advancing through the development of new technology, observing techniques, and post-processing methods.

Promotor: Prof. dr. I. Snellen, Co-Promotor: Dr. M. Kenworthy

Promotor: Christoph U. Keller, Co-promotores: Matthew A. Kenworthy, Frans Snik

The next generation of high-contrast imaging instruments on space-based observatories requires sophisticated wavefront sensing and control in addition to a high-performance coronagraph.

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PhD Defence

Promotor: B. van de Water, Co-Promotores: J.H.N. Meerman, F.J. Verbeek

In this project we develop algorithms to automatically detect a particular type of archaeological sites in satellite images of the Alps.

This thesis investigates the relations between metabolism and anatomy through the use of Magnetic Resonance Imaging (MRI).

We have studied shape with a particular focus on the zebrafish model system. The shape is an essential appearance of the phenotype of a biological specimen and it can be used to read out a current state or response or to study gene expression.

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Double Bind. Public service professionals coping with contrasting demands. How do public service professionals align their PSM with contrasting demands set by the organizational and social contexts in which they work?

PhD Defence

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

From surface science towards industrial practice using high-pressure scanning tunneling microscopy.

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This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Promotores: S.J. Edixhoven, P.Parent

Promotor: M.A.G.J. Orrit

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotor: C.U. Keller, Co-Promotor: F. Snik

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PLATO is a centre for research and development in education and training. 4 areas of expertise and 4 methods.

Can chemical safety assessment be improved with zebrafish embryo-based reporter assays?

Which immune mechanisms are involved in host defense against Staphylococcal infection?

Optical projection tomography (OPT) is a tomographic 3D imaging technique used for specimens in the millimetre scale.

High Performance Computing previously the domain of theoretical scientists and computer and software developers is becoming ever more important as a research tool in many research areas. A University facility, providing serious computational capabilities, combined with easy and flexible local access,…

This thesis focuses on the study of transient and variable radio sources in the universe.

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

How can zebrafish research help to understand and fight human cancer?

This page is under construction.

One of the ways of understanding another culture better is to examine what people experience when they read a text, or look at an image. Leiden experts have a lot of knowledge in this field, for example on culture in ancient Japan.

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Detection of cerebral beta-amyloid (Abeta) by targeted contrast agents remains of great interest to aid the in vivo diagnosis of Alzheimer's disease (AD). Bis-styrylbenzenes have been previously reported as potential Abeta imaging agents.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Science

The aim of this project is to study what makes an act or form of violence a specifically political reality.

In Shimmering Images, Eliza Steinbock traces how cinema offers alternative ways to understand gender transitions through a specific aesthetics of change.

How do documentary moving images and fictional narratives involve and evolve each other?

Promotor: B. van de Water

The reintegration of high profile ex-offenders frequently receives great political and public attention. While this attention, more often than not in the form of negative sentiments, may be understandable from a moral perspective, it raises several important questions: how do such offenders reintegrate…

This project aims to study the Aesopian fable from 1500 to the present day in its complex relationship between text, illustration and education, adopting a broad, transnational perspective.

Advancing the understanding of the interaction of light and matter on the single-quantum level is important for near-future quantum technologies but also to answer fundamental questions.

In 2018, the number of mobile phone users will reach about 4.9 billion. Assuming an average of 5 photos taken per day using the built-in cameras would result in about 9 trillion photos annually.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.