486 search results for “gpcr stabilization” in the Public website
-
EU Bank Resolution Framework: A comparative study on the relation with national private law
On 19 September 2019, Lynette Janssen defended her thesis 'EU Bank Resolution Framework: A comparative study on the relation with national private law'. The doctoral research was supervised by Prof.mr. W.A.K. Rank and prof. M. Haentjens.
-
Membrane Fusion Mediated Intracellular Delivery of Lipid Bilayer Coated Mesoporous Silica Nanoparticles
Alexander Kros and co-workers describe how mesoporous silica nanoparticles (MSNs) are delivered into cells via membrane fusion thereby omitting endocytosis pathways. Fusion is induced by a pair of complementary coiled-coil lipopeptides inserted into the membrane of cells and in the bilayer of lipid-coated…
-
Dynamic real-time substrate feed optimization of anaerobic co-digestion plants
Promotores: Prof.dr. T.H.W. Bäck, Prof.dr. M. Bongards (Cologne University)
-
Mast cell-mediated immune modulation in experimental Rheumatoid Arthritis and Atherosclerosis
In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.
-
Financial Collateral
November 2020 saw the publication of the book ‘Financial Collateral; Law and Practice’. This book was published by Oxford University Press, and edited and authored by Professor Matthias Haentjens. Other authors who contributed to the book are Anthony Zacaroli (High Court, Chancery Division), Yael Diamant…
-
Gauss's theorem on sums of 3 squares, sheaves, and Gauss composition
Promotor: Bas Edixhoven, Promotor: Qing Liu
-
Biodiversity and Sustainability (MSc)
The master’s specialisation Biodiversity and Sustainability at Leiden University provides students with a much better understanding of the biological processes which are essential for creating a sustainable society.
-
Photo-activation of ruthenium-decorated upconverting nanoparticles
Metal-based prodrugs based on ruthenium(II) polypyridyl complexes have proven to be very suitable for application in both photodynamic therapy (PDT) and photo-activated chemotherapy (PACT).
-
David Overy
Dr. at Agriculture and AgriFood Canada, Ottawa Research & Development Center - Canada
-
EU-STRAT: ‘The EU and Eastern Partnership Countries: An Inside-Out Analysis and Strategic Assessment’
What should the EU do to support Ukraine, Belarus and Moldova? How can the European Union adapt its policies towards these countries in a very difficult and challenging geopolitical context?
-
The (im)possibilities of addressing election interference and the public core of the internet in the UN GGE and OEWG
Article by Dennis Broeders in the Journal of Cyber Policy on the (im)possibilities of addressing election interference and the public core of the internet in the UN GGE and OEWG.
-
The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement
On 26 June 2019, Lisa Louwerse defended her thesis 'The EU’s Conceptualisation of the Rule of Law in its External Relations: Case Studies on Development Cooperation and Enlargement'. The doctoral research was supervised by Prof. C.A.P. Hillion.
-
Promoting Accountability for War Crimes: Should UN Peacekeepers be involved?
Tom Buitelaar is an Assistant Professor in the War, Peace & Justice programme of the Institute of Security and Global Affairs. This paper discusses four important challenges to the involvement of UN peace operations in international criminal justice: its effects on host state relations, peace and justice…
- Quantum Optics
-
Civil Society against Corruption in Ukraine: Political Roles, Advocacy Strategies and Impact
This project aims to provide evidence-based knowledge on the conditions for successful anti-corruption activism in Ukraine.
-
Post-Crimea Shift in EU-Russia Relations: From Fostering Interdependence to Managing Vulnerabilities
Ludo Block wrote the eleventh chapter of the book 'Post-Crimea Shift in EU-Russia Relations: From Fostering Interdependence to Managing Vulnerabilities'. His chapter 'Business as Usual? Police Cooperation under a Cloud of Political Animosity' can be found on page 204 of the book.
-
Synthetic Methodology Towards ADP-Ribosylation Related Molecular Tools
Phosphorylation affects all four major biomolecules – proteins, lipids, carbohydrates and nucleic acids – and plays a pivotal role in the most fundamental cellular functions.
-
Laura Heitman appointed as Professor of Molecular Pharmacology
As of 1 November, Laura Heitman has been appointed full Professor of Molecular Pharmacology at the Leiden Academic Centre for Drug Research (LACDR). Heitman has been working on the understanding and improvement of drug-receptor interactions in early drug discovery. ‘My ultimate aim is to make medicines…
-
Climate change presents African grazers with tricky decision
Lions limit their prey, such as zebra and gnu, in their options for adapting to global warming. This is what Leiden researcher Michiel Veldhuis, from the Institute of Environmental Sciences, and a group of international colleagues have discovered. The research was published today in Nature Ecology &…
-
Invited speakers
Speakers that have accepted to participate:
-
Chemical biology of glucosylceramide metabolism: fundamental studies and clinical applications for Gaucher disease
How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?
-
MAXCAP
The research project MAXCAP: Maximizing the integration capacity of the European Union: Lessons and prospects for enlargement and beyond starts with a critical analysis of the effects of the 2004-2007 enlargement on stability, democracy and prosperity of candidate countries, on the one hand, and the…
-
Regulating shadow banking - China's perspective
On 24 May 2017, the Hazelhoff Centre for Financial Law welcomed Shen Wei, Dean and Professor of law at Shandong University School of Law in China, for the 14th Hazelhoff Guest Lecture.
-
Natural deep eutectic solvents: A new green solvent from nature
- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?
-
Unfolding the principles of genome folding and dynamics in bacteria
What are the principles of genome folding and dynamics in bacteria?
-
Microbial Chemotaxis
In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.
-
Operando research in electrochemistry
The central theme of Rik Mom’s research group is to identify what the electrode-electrolyte interface looks like when electrocatalysis is taking place. Using specialized forms of Raman and X-ray spectroscopy, we study the chemical state and bonding environment of the electrode surface and near-surface…
-
Kraft Lab (Self-assembly in Biological and Soft Matter)
Research in the Daniela Kraft Lab focuses on self-assembly in biological and soft matter systems, ranging from anisotropic colloidal particles to lipid membranes, emulsions, and viruses.
-
Career prospects
The MSc IRD prepares you specifically for a career in international diplomacy, international government and non-governmental organisations, national or international public administration, ‘think tanks’ and research institutions, international interest associations or international business.
-
Education
CML’s education programme aims at training (under)graduate and graduate students for integrated and multidisciplinary sustainability research and for better decision making in managing the world’s natural resources, environmental quality and biodiversity.
-
Host-Microbe Interactions in Plant Sciences
Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…
-
Single gold nanorods in live cells
Visualization of biomolecules in living cells by tagging with gold nanoparticles.
-
Impact
Leiden Law School at the heart of society
-
SiTaSol
What are the life-cycle environmental impacts and risks to human health and ecosystems of a III-V/Si PV system? How can these be expected to change when the system is deployed at industrial scale? What are the most favourable recycling scenarios?
-
Self-assembly properties and applications of metal-binding peptides and proteins
It is estimated that approximately 30% of all proteins require a metal to function. Investigating the relationship between metal-binding and peptide/protein folding allows us to uncover fundamental rules for creating metallo-peptides and proteins, which in turn leads to the creation of new structures,…
-
The Unforeseen 2012 Crisis in Mali: The Diverging Outcomes of Risk and Threat Analyses
The 2012 crisis in Mali, where the state collapsed and terrorist groups took over the north, came as a surprise to many. Mali had been considered a poster-child for democracy and was judged as considerably more stable than its neighbors by leading quantitative indices of state fragility. This article…
-
Quantum Matter and Optics
The quantum nature of matter and light has grown into a broad and fruitful research field for theorists and experimentalists alike. It combines foundational research with toward applications, the most well known of which is the quantum computer.
-
Overcoming the Debye screening length with radiofrequency-operated graphene biosensors
Can a proposed new radiofrequency approach to graphene biosensors lead to groundbreaking changes in genome mapping?
-
Understanding emergence and growth of interests in daily life
How are interests embedded and experienced in daily life and to what extent can their origin and development be understood in terms of this contextualization?
-
Alternative delivery of a thermostable inactivated polio vaccine
In the near future oral polio vaccine (OPV) will be replaced by inactivated polio vaccine (IPV) as part of the eradication program of polio. For that reason, there is a need for substantial amount of safe and more affordable IPV for low-income countries. Bioneedles, which are biodegradable mini-implants,…
-
Anisotropic Colloids
While colloidal aggregates are often undesirable due to their random shapes, we exploit them as a starting point to synthesize patchy particles.
-
Foreign intelligence in the digital age. Navigating a state of 'unpeace'.
The Hague Program for Cyber Norms, a research program at the Institute of Security and Global Affairs, published its first policy brief, in which Dennis Broeders, Sergei Boeke and Ilina Georgieva explore the role of intelligence agencies in cyberspace and the (im)possibilities of oversight and regulation…
-
About this minor
The minor SSJ gives insight into security issues you read about in the newspaper: terrorist threats, criminality, integrated security and stability. Basic knowledge and research techniques are acquired centered around three themes: security, safety, and justice.
-
water quality and spatial heterogeneity: consequences for sediment stability and seston trapping
PhD Defence
-
Research
Research in the POD-group addresses all features of random phenomena – modelling, structuring, analysis, control, optimisation – and covers both fundamental and applied aspects.
-
Inverse Agonism and Constitutive Activity
-
-
Teaching
Research projects for students of the University of Leiden and other Dutch Universities are often available at the MacBio group. The research lines are also described in the Research section. For details of specific projects contact the supervisor (Ubbink, Dame, Boyle).
-
A diverse meadow is less easy to damage
Plant communities consisting of many different species are less vulnerable to attacks of plant eating animals or diseases than less diverse communities. It also helps if plant species in one community are not closely related to each other. That is the outcome of an international study published in Nature…
-
Biotransformation of plant metabolites in microorganisms
- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?
-
PhD Theses
A full overview of MacBio PhD Theses.