The Bioinformatics and Genomics Core provides bioinformatics advice and genotyping services. The researchers that lead and work for this facilities are experts in their fields and are available for consultation regarding experimental design and interpretation of results.

How did toxin genes evolve from harmless physiological genes?

The facility develops and applies advanced, high-throughput methods for genomic research.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

What are the principles of genome folding and dynamics in bacteria?

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Novel algorithms to detect indels and structural variants from next- and third-generation sequencing data.

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

Can the venom of snakes, scorpions and other animals be sources of new antibiotics?

On 29 June the startup company Future Genomics Technologies will be launched. Its aim is to make DNA technology and research available for businesses faster. Future Genomics Technologies is a collaboration between DNA research laboratory BaseClear and Leiden University.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Conference

Leiden evolutionary biologist Maurijn van der Zee has co-operated on an enormous international project to describe the genetic material of the pea aphid Acyrthosiphon pisum. The more than 100 authors involved in the project have published their findings in the online magazine PLoS Biology.

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

What are the phylogenetic relationships among the members of speciation bursts?

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

Promotor: M. Ubbink, Co-Promotor: R. T. Dame

Do understudied animals contain hidden species?

Mapping of bacterial genomes to combat infectious diseases

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Leiden researcher Dr Ben Zonneveld has determined the size of the genome - the amount of DNA per nucleus - of wild tulips. His conclusion is that there are more than 87 wild species. Various possibly new species have been discovered.

How do balanced lethal systems originate and persist in nature?

An international team from the Netherlands, France, Norway and Austria demonstrate how new sequencing technologies can be used to efficiently generate the genome, DNA, sequence of an endangered animal, the European Eel.

‘It's where disciplines intersect that the most exciting scientific questions arise.' This was the message given by John van Noort, Professor of Biophysics, in his inaugural lecture. His own research is at the interface between biology and physics. Inaugural lecture 23 April.

On March 21 2018, a study was published in Nature, co-authored by Professor M. Soressi from the Faculty of Archaeology of Leiden University, announcing the sequencing of five new Neandertals, raising the number of high-coverage sequenced Neandertals from two to seven. A tooth lost by a Neandertal woman…

This month, a paper was published in Nanoscale by scientists from Dr. Alireza Mashaghi group at the Systems Biomedicine and Pharmacology Division in collaboration with the group of Dr. Sander Tans from TU Delft/AMOLF. In this paper, the authors studied how nanoscale spatial confinement affects the fold…

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Lecture, Van Leeuwenhoek Lecture on BioScience

Course, TechTalk

PhD Defence

Freek Vonk and Mike Richardson, with many collaborators, have published two snake genomes in two parallel articles in the prestigious journal PNAS. Their new findings provide insight into the co-evolutionary arms race between predator and prey.

The Science faculties of Universitas Indonesia (UI) and the Universiteit Leiden signed agreements on Tuesday April 12 that will strengthen cooperation between the Faculties. The agreements were signed at the closing of a two day visit of a delegation from Indonesia. The delegation, which was led by…

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