- Which metabolites could be components of NADES? - How can we prove the presence of NADES in nature? - What are the roles of NADES in nature? - How to apply NADES in life sciences?

Physics and Engineering Approaches to Biomedicine and Pharmacology

In April, the X-omics initiative was granted 17 million euros from the Dutch Organization for Scientific Research. The subsidy is part of the National Roadmap for large-scale scientific infrastructure, intended to build or renew large-scale research facilities. What new insights will this investment…

Can new variants of daptomycin and the polymyxins be found?

Source: Nature Biotechnology, Volume 2014, Issue June (2014)

The availability of complete plant genome sequences together with the ever increasing amount of data on the molecular, cellular and physiological mechanisms of plant development require mathematical and computational models to obtain a complete overview of and generate new insights into the quantitative…

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Bacteria often experience external challenges, such as changes in environmental conditions or attacks by bacteriophages.

Promotor: Prof.dr. J. Brouwer, Co-promotor: Dr. Remus Th. Dame

An integrated approach of physiological concepts, advanced statistical approaches and large clinical datasets.

Which compounds and microorganisms that live near and inside plant roots are beneficial? Can we use this knowledge to improve the health and growth of crop plants?

What are the differences between the trade in Chinese herbal drugs in Europe between 1800 and now? Can we see the major metabolic changes after 200 yours?

Promotor: Prof.dr. R. Verpoorte, Co-promotores: Dr. Y.H.Choi, N.R. Mustafa

To increase clinical success rate of drugs, a better understanding of drug action mechanism and disease dynamics is required. Metabolomics, which studies small molecules involved in biochemical processes in organisms, has shown to be a useful tool for this better understanding.

Advanced mass spectrometry of glycosphingolipids takes the central stage in this thesis. Investigations focus on characterization of glycosphingolipid metabolism in health and disease with emphasis to the detection and accurate quantitation of known and so far unknown glycosphingolipids and closely…

Are traces of fire use detectable in ancient hominin genomes?

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

A major new study of ancient DNA has traced the movement of people into southern Britain during the Bronze Age. In the largest such analysis published to date, scientists examined the DNA of nearly 800 ancient individuals. Publication in Nature on December 22, 2021.

The long-held desire - to link structure directly to function and to explain molecular mechanisms based on basic chemical or physical principles - is finally coming closer, satisfying not only our scientific curiosity but also offering new solutions to the many challenges in the field of health, energy…

The Institute of Biology Leiden (IBL) is an internationally oriented institute for research and education in biology.

Our object is to identify and characterize transcription factors involved in lignocellulosic biomass degradation in the filamentous fungus Aspergillus niger.

We aim to gain a better understanding of the natural disease progression of ALS in order to improve clinical trial design and analysis and to support drug discovery and clinical development of new drugs.

PhD defence

Annually, the Dutch Palynologische Kring invites nominations for the Florschütz Award for best MSc thesis in Palynology and Palaeobotany. This year, the thesis of Archaeology alumna Oda Nuij was deemed to be the best one. Oda was surprised to hear she won, since she was not sure that the thesis would…

Lecture

How can zebrafish research help understanding human diseases?

How might we include circularity into the models often used in IPCC reporting (in technical language, how can IAMs, dMFA models and CGE models be integrated?) What are possible futures for global resource use and what are the consequences for greenhouse gas emissions in these scenarios?

How are links between macro-invertebrate diversity and ecosystem functioning influenced by anthropogenic pressures?

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

Analysis of drug adversity

An overview of Quantitative Pharmacology projects

This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).

Lecture, Special Topics in Dialectology (2023)

PhD defence

PhD defence

What if you could watch a CT scan live, instead of analysing the images afterwards? If it is up to the Leiden mathematician Jan-Willem Buurlage, that will soon be a reality. He is developing methods to make the algorithms behind 3D scans faster. Quite a challenge: ‘Just like mathematicians, computers…

Conference

An international and multi-disciplinary research consortium spent two days at Leiden University for the launch of their ‘GOLD MATTERS’ project, funded jointly by NORFACE and Belmont Forum. The project 'Sustainability Transformations in Artisanal and Small-scale Gold Mining: A Multi-Actor and Trans-Regional…

Leiden archaeologists investigate how people in the past impacted their environment. Together with scientists, environmental scientists, and humanities experts, they use this information to draw conclusions about the present – and show what we can learn from it for the future.

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence

PhD defence