Promotor: Prof.dr. J.N. Kok, Co-promotor: F.J. Verbeek

This dissertation attempts to describe the linguistic history of Hittite on the basis of a systematic etymological treatment of its entire inherited lexicon, precisely analyzing the phonological and morphological developments.

Bronze Age settlement sites in the Dutch river area (c. 2000-800 BC)

Developing robust algorithms and theory for establishing cause-effect relationships from observational data that scale up to large data sets

The Netherlands X-omics Initiative is a new facility as part of the National Roadmap for Large-Scale Research Infrastructures. It is partly funded by NWO with a total budget of 40 million euro. The project started on September 2018 and will last for ten years.

Do large deletions represent a risk during CRISP/CAS9-mediated genome editing in plants?

PhD defence

This thesis is about cosmological inflation and its relation to observations.

Research projects

Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

Our research primarily focuses on the early universe and its origins in theories that go beyond the Standard Model of particle physics.

This thesis discusses the development in Proto–Indo–European, Latin and Romance of a word–formation pattern which the most adequate terminology in use dubs ‘verbal government compounds with a governing first member’; I use the shorthand ‘pickpocket compounds’.

Lecture

The metabolomics facility is proud to be featured on the NWO website which reflects the landscape analysis of large-scale research infrastructure in the Netherlands implemented by the Permanent Committee for Large-Scale Scientific Infrastructure.

The Dutch X-omics Initiative has received seventeen million euros from NWO as part of the National Roadmap for Large-Scale Infrastructure. Leiden University’s metabolomics research led by Thomas Hankemeier is one of the participators.

PhD defence

PhD defence

PhD defence

PhD defence

Nature uses a special class of histone proteins, histone variants, to modulate the properties of chromatin at defined genomic locations.

The RNA guided endonuclease based on the CRISPR/Cas system of Streptococcus pyogenus is a potent new tool for genome engineering in plants.

Plant Sciences' contribution to the Host-Microbe Interactions research theme is to dissect how microorganisms and microbiomes interact with the plant host and the insects on those plants, and how these insights may be harnessed to improve plant growth and health, by steering microbiome composition and…

The SNP genotyping line offers flexible genotyping for small and large projects at affordable price and high quality. The use as SNPs as molecular markers is very versatile and can be used for a wide variety of scientific questions ranging from paternity analysis, conservatuion genetis towards QTL…

PUMA aims at composing a geological map of the urban mine of Amsterdam for a selection of metals. Where are main deposits of copper, iron and aluminium located, when will they become available for secondary production, in what state and shape are they?

Key publications of the Biomedical Microscale Analytics group.

Cultural anthropologist Annet Pauwelussen has been invited by the University of Washington to participate in an expert meeting on 'Global Measures of the Contribution of Small-Scale Fisheries to Sustainable Development'. 29 - 30 May 2018, Seattle.

The ongoing increase in antimicrobial resistance combined with the low discovery of novel antibiotics is a serious threat to our health care.

Does a moving hybrid zone leave a genomic footprint?

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

This study aims to make a practical contribution to a new understanding and use of 3D reconstructions, namely as ‘laboratories’ to test hypotheses and visualize, evaluate and discuss alternative interpretations.

PhD defence

Catalysts are indispensable in everyday life. We know what they do and more or less how they do it, but we still lack a fundamental understanding about their functioning at an atomic scale. Therefore, Irene Groot from the Leiden Institute of Chemistry develops new measuring techniques to unravel the…

- How to deconvolute metabolic mixture of precursors and products by biontransformation? - How to optimize the reaction conditions to produce bioactive compounds in biotransformation? - What is the effect of co-treating fungi or bacteria for biotransformations?

Development of Natural Resource for New Medicines

The master’s specialisation BioTherapeutics at Leiden University is a two-year programme which trains students in research in specific drug delivery techniques. The programme also examines the development of new therapeutic approaches to treat immune-based disorders, such as atherosclerosis, metabolic…

Dr. at Max Planck Institute for chemical Ecology, Jena - Germany

This dissertation studies the Asymptotics of Bayesian nonparametric inference for Gaussian linear models.

Research lines within the Pharmacy group:

On 15 November Joost Visser started as Professor of Large Scale Software and Data Science at the Leiden Institute of Advanced Computer Science (LIACS). He will head the software engineering research at LIACS and becomes head of the ICT in Business and the Public Sector master's program.

Conference

Ancient Greek was spoken in a large number of different dialects. Although we do not find direct evidence for syllabic liquids in any of our sources, comparative evidence shows that these sounds must have been present in Proto-Greek, and that they were retained until comparatively recently in the prehistory…

This study aims to provide a long time perspective of human landscape manipulation. Studying the roles of prehistoric foragers in past ecosystems is of great importance to establish the character of past 'natural' landscapes and to enhance the management of current ones.

PhD defence

The emergence of metalwork deposition during the Bronze Age in Northwest Europe, c. 2300-1500 BC

Promotores: Prof.dr. J. Schaye, Prof.dr. S.D.M. White (MPA Garching)

Ichthyoarchaeological and biomolecular research to assess the trophic ecology of the Rhine-Meuse delta in the Holocene