What are the functions of autophagy in the filamentous fungus Aspergillus niger?

The mission of the Plant Science research programme is to contribute to the sustainable production of high quality crops, flowers and high-value bio-based products. This is realised by generating fundamental knowledge of basic biological processes related to development of plants and their interaction…

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

The main purpose of this book is to give a description of the Cholón language as represented in the Arte de la lengua cholona (ALC), a colonial grammar written in 1748 by a Franciscan friar, named Pedro de la Mata. The ALC was transcribed by Fray Gerónimo Clota in 1772. This grammar is kept in the British…

PhD at Molecular Biology and Biochemistry Department, University of Malaga - Spain

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

On Monday-Wednesday 10-12 June 2019, Jeroen Wolbers, Wout Broekema and Sanneke Kuipers represented the Institute of Security and Global Affairs (ISGA) at the fourth edition of the Northern European Conference on Emergency and Disaster Studies (NEEDS).

This study looks at the diverse phonological systems found within Central Chadic, and reconstructs the phonological system of their ancestor language.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Key publications of the Analytical BioSciences and Metabolomics group

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

Promotores: K.J. Batenburg, B. Koren

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

Promotor: M.L. van Hecke, Co-Promotor: B.P. Tighe

Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.

Through his project we will unravel the global regulatory networks that control gene expression in Streptomyces bacteria and allow them to properly respond to major changes in the environment; we will then harness this knowledge to activate and identify novel antibiotics

The 2004 Indian Ocean tsunami caused immense destruction and over 170,000 deaths in the Indonesian province of Aceh. The disaster spurred large-scale social and political changes in Aceh, including the intensified implementation of shari‘a law and an end to the long separatist conflict. After the Tsunami…

This dissertation provides an overview of the phonological developments of the Qinghai-Gansu languages, comparing them to the reconstructed ancestral language.

Development of micro-scale analytical tools to be used to address relevant biomedical questions in the field of neuroscience, and other application areas intrinsically dealing with small sample amounts.

On 8 July, the symposium 'The digital reconstruction of the crucifixion of the Lindau master (ca. 1425)' will take place at the auditorium of Museum Catharijnecovent, from where it will also be broadcasted online.

We focus on natural products research, traditional medicine, ethnobotany and phytochemistry.

How can Agile methods improve the quality of project management in IT organizations? Acquire the knowledge necessary to lead an enterprise agile transformation by applying the Scaled Agile Framework, and its underlying principles of lean thinking, and product development flow. This course is organised…

William Pestle and Jason Laffoon recently published a new article entitled 'Quantitative paleodietary reconstruction with complex foodwebs: An isotopic case study from the Caribbean' in the Journal of Archaeological Science: Reports.

This dissertation assesses the influence of British Celtic on the phonological development of English during and shortly after the Anglo-Saxon settlement period, ca. AD 450-700.

The CIGR comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC), the Leiden Academic Centre for Drug Research (LACDR) and the Leiden Institue of Physics (LION).

Research aims: Identification of key genes involved in programming the cellular architecture of A. niger & Genetic engineering of A. niger in order to improve its secretory capacities and rheological behavior under industrial fermentation conditions.

Authoritative and cutting-edge, Bacterial Chromatin: Methods and Protocols aims to be useful as an up-to-date reference work for scholars in the bacterial chromatin field, those entering the field from adjacent research fields, and scientists in the eukaryotic chromatin field.

The CMCB brings together a diverse range of unique expertise in microbial cell biology. Members of the CMCB investigate both model and non-model organisms, bacteria and archaea, pathogens and non-pathogens.

Neurodegenerative diseases, including Parkinson’s disease (PD), are increasing in prevalence due to the aging population. Despite extensive study, these diseases are still not fully understood and the lack of personalised treatment options that can target the cause of the diseases, rather than the symptoms,…

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Is it possible to synthesize industrially relevant compounds in a sustainable manner through the use of light-capturing cyanobacteria?

A palaeogeographical reconstruction of Bronze Age West-Frisia (2000-800 BC)

Promotor: S.M. Verduyn Lunel

The imaging group focuses on bio-imaging, image analysis and visualization.

Inaugural lecture

Inaugural lecture