Leiden evolutionary biologist Maurijn van der Zee has co-operated on an enormous international project to describe the genetic material of the pea aphid Acyrthosiphon pisum. The more than 100 authors involved in the project have published their findings in the online magazine PLoS Biology.

Tomography is a powerful technique to non-destructively determine the interior structure of an object.Usually, a series of projection images (e.g.\ X-ray images) is acquired from a range of different positions.

HomininSpace is an agent based modelling and simulation system in which fluctuating carrying capacity is the key attractor for hominin dispersal. A parameterized and spatially explicit reconstructed palaeo-environment models available energy in the form of secondary biomass using reconstructed climate…

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

Promotor: J.P. Abrahams, Co-promotor: T. Grüne

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Large-scale computing infrastructure, such as supercomputers, cluster, and clouds, are already pervasive, most members of our society interact with them daily: social networks, government services, media streaming services--all systems heavily interfacing with the members of our society--are powered…

Promotor: Prof.dr. T. Hankemeier, Co-promotor: R.J. Vreeken

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

PhD defence

Predicting whether someone will fall ill and which treatment will benefit them most: that is the aim of the techniques that Professor of Analytical Biosciences Thomas Hankemeier and his research group are developing at Leiden University. In order to scale up and further develop this technology, he works…

The theoretical explanation of cosmic acceleration is nowadays one of the biggest puzzles in cosmology.

Anna Scott is a Canadian pianist-researcher interested in using the early twentieth century recordings of the Brahms circle of pianists to question persistent gaps between the loci of knowledge, ethics, and act in both modern mainstream and historically-informed performances of Brahms’s late piano w…

Clearance is the most important pharmacokinetic parameter for drug dose selection. Pharmacokinetic information is typically first available in the adult population, and in general only limited pharmacokinetic data are available in children when drugs enter into the market. It is therefore of the utmost…

All life on earth contains DNA, which is used to store biological information. Organisms compact their DNA in order for it to fit inside their cell(s).

Promotor: E.R. Eliel, Co-Promotor: M.J.A. de Dood

Quantifying physical activity (using accelerometers) and combining the frequency and intensity of activities with health data (brain MRI, traditional clinical parameters and metabolomics) is of utmost importance to monitor mobility and health among older individuals and study health promotion during…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Leiden researcher Dr Ben Zonneveld has determined the size of the genome - the amount of DNA per nucleus - of wild tulips. His conclusion is that there are more than 87 wild species. Various possibly new species have been discovered.

A technique originally developed for satellite imaging can now be used to recover pictographic texts from underneath the surface of a five hundred year old Mexican manuscript.

Attitudes towards cultural heritage have long been characterised by an ‘endangerment sensibility’ concerned with preventing losses. Recently, however, critical heritage scholars have argued that loss can be generative, facilitating the formation of new values and attachments. Their arguments have focused…

What can languages spoken in the Lesser Sunda Islands today tell us about the histories of its various population groups?

This thesis is based on five papers on several topics.

Central Limit Theorem associated to a particular case of ergodic total automorphisms. Finally, Chapter 6 proves that the isoperiodic foliation is connected for a meromorphic differential with three poles on a torus.

A research data infrastructure in computational social science

What kinds of vocal music were not typically transmitted in written musical notation? Can specific ‘lost’ song forms - siciliane, giustiniane, le Grechesche, gli stili “regionali“ nel canto del quattrocento - be more precisely identified than they have been until now, both in musicological research…

Promotor: J.W.M. Frenken, Co-Promotor: R. Felici

Female and male songbirds sing equally elaborate songs in some species, but in others, females do not sing like males or not at all. How did such pronounced differences in male and female communication evolve?

How to reconstruct the middle parts (videlicet haute-contres, tailles and quintes) from French orchestral pieces, which survived only in their reduced forms (featuring primarely dessus and continuo), according to historical examples?

In 2010, the remnants of a 16th century indigenous village were discovered in St. Vincent, on the construction terrain of the new International Argyle Airport.

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Voting Advice Applications represent popular election campaign tools in many countries, enabling voters to discover which party or candidate provides the best match with their political preferences. Political scientists Martin Rosema (University of Twente) and Tom Louwerse (Leiden University) examine…

The work in this thesis describes the fundamental role of Lkb1 as a conductor of metabolism-related processes in zebrafish larvae.

Leiden biotech startup Azafaros has successfully completed a funding round, raising 25 million euros of investments for developing treatments of rare metabolic disorders. The company holds exclusive license to a library of novel patented compounds discovered by experts from Leiden University.

What are the 'dark' components of the universe?

ChEMBL is a large-scale drug discovery database containing bioactivity information primarily extracted from scientific literature.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: M.R. Hogerheijde

In condensed matter systems electron-electron interactions, negligible in everyday metals, can dramatically alter the electronic behavior of the system. Examples of such altered behavior include high-temperature superconductivity and modulation of the electron density.

What are the phylogenetic relationships among the members of speciation bursts?

An international team from the Netherlands, France, Norway and Austria demonstrate how new sequencing technologies can be used to efficiently generate the genome, DNA, sequence of an endangered animal, the European Eel.

Promotor: W.Th.F. den Hollander Co-Promotor: F.M. Spieksma

‘It's where disciplines intersect that the most exciting scientific questions arise.' This was the message given by John van Noort, Professor of Biophysics, in his inaugural lecture. His own research is at the interface between biology and physics. Inaugural lecture 23 April.

In this work the reconstruction of a tau neutrino signal in the KM3NeT detector is discussed.

The thesis describes experimental steps towards reduction of friction on the macroscopic scale by scenarios of thermo- and superlubricity well-known on the nanoscale.

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

In this thesis, I targeted the orchid genus Lepanthes, one of the six genera of angiosperms that surpasses 1,000 species in the Neotropics, as a study model to investigate the evolutionary processes that promoted species diversifications.

Promotor: J.W.M. Frenken

Lecture, Comparative Indo-European Linguistics (CIEL) Seminars