The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).

Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.

Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…

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A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…

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In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

Science, Institute of Biology Leiden (IBL)

Investigating neurobiological endophenotypes of Social Anxiety Disorder

Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

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Science, Leiden Institute of Chemistry (LIC)

Are traces of fire use detectable in ancient hominin genomes?

How does invasive hybridization affect threatened native species?

This study analyses the prehistory of a northeastern Siberian population, the Sakha, from both a molecular-genetic and a linguistic perspective.

The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.

Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten

Science, Leiden Institute of Advanced Computer Science (LIACS)

Science, Leiden Institute of Advanced Computer Science (LIACS)

Cardiovascular disease is the leading cause of death worldwide.

Promotor: Roeland M.H. Merks

Promotor: Prof.dr. G.R. de Snoo

Promotores: J. Jonkers, K.E. de Visser

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis

How do genetic and environmental factors make us vulnerable to depression?

Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke

Promotor: Prof.dr. T.H.W. Bäck

PhD defence

This project explores the community of engineers in Sri Lanka and their role with regard to three domains of inquiry.

Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.

Promotor: P.M. Brakefield

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

PhD defence

An examination of academic organization at the forefront of the biotechnology revolution

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal

Higher design and engineering educators have different views on what a new or renewed curriculum should entail, content-wise as well as pedagogically. This research aims to describe how these ‘curriculum perspective perceptions’ influence working definitions, end goal formulation, and the scope of results…

Promotor: Prof.dr. R.M.H. Merks

Bandura Witharana defended his thesis on 27 September 2018

... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.

The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.

We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.