2,051 search results for “genetically engineered mouse models” in the Public website
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Resistance to PARP inhibition by DNA damage response alterations in BRCA1/2-deficient tumors
Inactivating mutations in BRCA1 or BRCA2 genes predispose to several types of cancer.
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Cancer chess: molecular insights into PARP inhibitor resistance
The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…
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Using insertional mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Regulation of actomyosin contraction as a driving force of invasive lobular breast cancer
In this thesis, we used genetically engineered mouse models and a variety of cell-culture based assays to identify genes and pathways that are involved in the development and treatment of invasive lobular carcinoma (ILC).
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Cholesterol metabolism in mouse models of atherosclerosis and adrenal steroidogenesis
Cholesterol influences many pathways, including serving as precursor for adrenal steroidogenesis. Imbalance of cholesterol levels has been implicated in several diseases including cardiovascular diseases and its underlying pathology, atherosclerosis.
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Development of a Transgenic Mouse Model to Study the Immunogenicity of Recombinant Human Insulin
Mouse models are commonly used to assess the immunogenicity of therapeutic proteins and to investigate the immunological processes leading to antidrug antibodies. The aim of this work was to develop a transgenic (TG) Balb/c mouse model for evaluating the immunogenicity of recombinant human insulin (insulin)…
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Genetic syndromes
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Development of innovative engineered models for viral diseases
A main goal of MSBB research is to address the major bottle-necks in combatting viral diseases: the lack of experimental models that are representative of human pathology and are cost effective and versatile. Viral diseases such as those that cause viral hemorrhagic syndromes or severe acute respiratory…
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Genetic risk & atypical development: 22q11 Syndrome
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Genet Haile
Faculty Governance and Global Affairs
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Engin Yüksel
Faculty of Humanities
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Molecular Genetics and Biotechnology (MSc)
In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.
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Junior Technician for Metabolic Engineering
Science, Institute of Biology Leiden (IBL)
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Extremely shy and genetically close
Investigating neurobiological endophenotypes of Social Anxiety Disorder
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Zebrafish as vertebrate model of Gaucher disease
Lysosomal storage disorders (LSDs) are a group of orphan diseases characterized by lysosomal dysfunction or impaired lysosomal catabolism and affect collectively about 1 in 5000 live births.
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Dedicated genetics and compound libraries
This page is under construction.
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Assistant Professor in Chemical Genetics
Science, Leiden Institute of Chemistry (LIC)
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Fire use in human evolution: A genetic approach
Are traces of fire use detectable in ancient hominin genomes?
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The complicated conservation problem of genetic pollution
How does invasive hybridization affect threatened native species?
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Contact in the Prehistory of the Sakha (Yakuts): Linguistic and Genetic Perspectives
This study analyses the prehistory of a northeastern Siberian population, the Sakha, from both a molecular-genetic and a linguistic perspective.
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Towards a working model of industry and higher education collaboration in enhancing engineers’ soft skills for better employability
The discussion on employability of higher education graduates has been around for several years, with more emphasis in the 21st century. Yet, universities are still challenged in the pursuit of providing work-ready graduates who can meet industry expectations.
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Interactive scalable condensation of reverse engineered UML class diagrams for software comprehension
Promotores: Prof.dr. J.N. Kok, Prof.dr. M.R.V. Chaudron, Co-Promotor: P. van der Putten
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Research Software Engineer
Science, Leiden Institute of Advanced Computer Science (LIACS)
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Research Software Engineer
Science, Leiden Institute of Advanced Computer Science (LIACS)
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Cholesterol metabolism and hematopoiesis interaction in atherothrombosis
Cardiovascular disease is the leading cause of death worldwide.
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Computational modeling of angiogenesis: from matrix invasion to lumen formation
Promotor: Roeland M.H. Merks
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Genetic diversity in the lion (Panthera leo (Linnaeus 1758)): unravelling the past and prospects for the future
Promotor: Prof.dr. G.R. de Snoo
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Pulling the strings on anti-cancer immunity
Promotores: J. Jonkers, K.E. de Visser
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Evaluation of the zebrafish embryo as an alternative model for hepatotoxicity testing
Promotor: Prof.dr. B. van de Water, Co-promotores: L.T.M. van der Ven, A.S. Kienhuis
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Genetic, biochemical and neural correlates of vulnerability to depression.
How do genetic and environmental factors make us vulnerable to depression?
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Abstract delta modeling: software product lines and beyond
Promotor: Prof.dr. F.S. de Boer, Co-promotor: D. Clarke
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Different Design Space Description Methods for Analysing Combustion Engine Operation Limits
Promotor: Prof.dr. T.H.W. Bäck
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Genetic-Tracing of CD8+ T cell fate decisions
PhD defence
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Negotiating Power and 'Constructing' the Nation: The Engineering Profession in Sri Lanka
This project explores the community of engineers in Sri Lanka and their role with regard to three domains of inquiry.
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PI3K signaling and adherens junctions in invasive lobular breast cancer
Invasive lobular carcinoma (ILC) is the second most common type of breast cancer.
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Temperature effects on genetic and physiological regulation of adaptive plasticity
Promotor: P.M. Brakefield
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Molecular engineering of plant development using Agrobacterium-mediated protein translocation
Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa
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Genetics and Life Course Epidemiology of Cardiometabolic Disease
PhD defence
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Universities as engines of technological change
An examination of academic organization at the forefront of the biotechnology revolution
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Mathematical modelling of advanced herbal extraction
Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?
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Phenotypic engineering of photosynthesis related traits in Arabidopsis thaliana using genome interrogation
Promotor: P.J.J. Hooykaas, Co-Promotor: E.J. van der Zaal
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Curriculum Perspective Perceptions within Higher Design and Engineering Curriculum Innovation
Higher design and engineering educators have different views on what a new or renewed curriculum should entail, content-wise as well as pedagogically. This research aims to describe how these ‘curriculum perspective perceptions’ influence working definitions, end goal formulation, and the scope of results…
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High-throughput simulation studies of angiogenesis - Reverse engineering the role of tip cells and pericytes in vascular development
Promotor: Prof.dr. R.M.H. Merks
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Negotiating Power and Constructing the Nation: Engineering in Sri Lanka
Bandura Witharana defended his thesis on 27 September 2018
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Self-regulation models
... which build on self-regulation and stress-regulation theories and considers the modification of cognitions as a mediator of therapeutic change.
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Bayesian uncertainty quantication in complex models
The aim of this project is to determine in which cases uncertainty statements resulting from a Bayesian statistical analysis can be trusted.
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Abstract Behavioral Specification: unifying modeling and programming
We strive to address the challenge of constructing a modeling language to write software which can take advantage of recent hardware developments (multicore, cloud) without compromising in its abstraction levels.