We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.

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In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

Investigating neurobiological endophenotypes of Social Anxiety Disorder

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

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Are traces of fire use detectable in ancient hominin genomes?

This study analyses the prehistory of a northeastern Siberian population, the Sakha, from both a molecular-genetic and a linguistic perspective.

How does invasive hybridization affect threatened native species?

Representing Japanese Colonial 'Heritage' in Taiwan

Promotor: Prof.dr. G.R. de Snoo

Globalization, migration, technological innovation and climate change pose challenges to citizens in European countries. These challenges test the limits of cross-national and cross-generational solidarities, touching upon the very foundations of governance and society. This research program aims at…

The authors in this volume explore how external innovations (products, technologies, services, institutions and processes) have been appropriated in African societies in order to be acceptable and relevant to local conditions, expectations and demands.

A monumental and extraordinary Early Iron Age Hallstatt C barrow from the ritual landscape of Oss-Zevenbergen

Welcome to the Global Transformations and Governance Challenges (GTGC) programme at Leiden University!

How do genetic and environmental factors make us vulnerable to depression?

Promotor: P.M. Brakefield

One of the three long-term research interests of our group concerns the Transformation of the Roman World (c AD 450-900).

Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.

How such did the traditional text of the Sinews Transformation Classic remain interesting to a changing readership?

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.

This project is a three-year collaborative research between European and Chinese researchers (2015-2018). As a part of the China-Europe “Understanding Population Change” Collaborative Research Initiative, the project utilizes multidisciplinary research methodologies (social and cultural anthropology,…

Natascha van der Zwan, Assistant Professor at Leiden Univeristy, together with two other authors, wrote a book that explored some of the ways coronavirus is impacting the global capitalist system – and how this could change for better and for worse.

On 31 January 2018 Vestert Borger defended his dissertation entitled ‘The Transformation of the Euro: Law, Contract, Solidarity’. The dissertation has been written under the supervision of Professor Stefaan Van den Bogaert (supervisor) and Dr Jorrit Rijpma (co-supervisor).

The article 'Co-productive agility and four collaborative pathways to sustainability transformations' is published in Global Environmental Change and accessible via OpenAccess. Professor Anthropology of Sustainability and Livelihood Marja Spierenburg of the Institute of Cultural Anthropology and Development…

The applications of studying the early development of insects range from agriculture to material science.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

This subproject, carried out by post-doctoral researcher Dr. O. Nieuwenhuyse, investigates changes and continuities in the functional, social and symbolic uses of the material culture, c. 6800-5800 BC. A contextually oriented approach is adopted, which pays attention to the local socio-economic and…

Sonorous phenomena are always on the verge of becoming something else. As it unfolds, sound constitutes spaces, mediates presence, articulates time. Furthermore, it may prompt emotions, generate awareness, organise patterns of behaviour or trigger a sense of belonging. As sound becomes audible, it is…

This recently released book takes a critical view of conceptual issues and practical problems that inevitably emerge when ‘excellence’ takes center stage in science systems in the Global South. What is ‘excellent science’? And how to recognize and assess it? After decades of inquiry and debate there…

In this project, we will study the genetic and environmental drivers of woodiness and stem lignification at the level of plant‐to‐gene‐to‐molecule.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

Fungal food spoilage often starts with a contamination with spores. Experimental data strongly indicate the existence of subpopulations of spores with different levels of resistance to preservation methods.

Starting from Husserl’s somewhat controversial claim about the immortality of the constituting subjectivity, this thesis uses the limit-case of death in order to present a phenomenological exploration of the notion of subjectivity and its relationship to nature. It also offers a second-order discussion…

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Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.

‘The Survival of Pliny in Padua. The Botanical Renaissance and the Transformation of Classical Scholarship’ in: Transformations of the Classics via Early Modern Commentaries, ed. by K.A.E. Enenkel. Intersections 29 (Leiden/Boston: Brill, forthcoming autumn 2013), pp. 327-62.

Agrobacterium tumefaciens, a gram-negative plant pathogen belonging to the family Rhizobiaceae, is the causative agent of crown gall disease, which can affect many plant species including agronomically important ones.

How is Pol θ responsible for T-DNA integration, and how do other DNA double-strand break repair pathways interact with Pol θ? How may we manipulate T-DNA integration to stimulate error-free integration at a predetermined genomic site?

Promotor: P. J. J. Hooykaas Co-promotor: B. S de Pater

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

From Crisis to Critique

Irna Hofman defended her thesis on 10 January 2019.

This thesis addresses the problem of designing performance and energy efficient embedded streaming systems, that is, systems which process a stream of input data coming from the environment and generate a stream of output data going into the environment.

Lecture, Research seminar

Promotor: A.P.IJzerman Co-promotor: A. Bender

How can theatricality act as a mediating process between public space and public as ‘audience’? Does the presence of an observer change the nature of the observed and if so, how?

This abrupt climate change of 8200 years ago (the so-called 8.2k calBP climate event) has received wide attention among natural scientists, also because of today's rapid climate changes and their impact on our own society. The archaeological implications, however, have not been investigated so far.…