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Local Knowledge Syndrome and Donor-Promoted Public Sector Reforms in Developing Countries. Effective development often fails because relief organizations don't study the local knowlegde and problems, says Moosa Elayah. A Local Bank of Knowledge can be the answer.

The role of language in self-regulation and social behavior in children with an extra X chromosome

FSW Professor Jan Dirk Blom has written a book on Alice in Wonderland syndrome. This is the first scientific book on this rare disorder, which was first described in 1955 by the British psychiatrist John Todd. Todd was inspired by the famous book by Lewis Carroll, in which Alice experiences all kinds…

Brain development in children with an extra X chromosome as compared to children with autism: evidence from MRI

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

In the master’s specialisation Molecular Genetics and Biotechnology at Leiden University students are trained by experts in the areas of molecular biology, microbiology, plant genetics, cellular imaging, animal disease models, and various –omics technologies and the corresponding bioinformatics.

Investigating neurobiological endophenotypes of Social Anxiety Disorder

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

Promotor: Prof.dr. J. den Hertog

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Are traces of fire use detectable in ancient hominin genomes?

This longitudinal study is focused on neurodevelopmental problems in young children with XXY, XXX and XYY, aged 1 to 6 years.

How does invasive hybridization affect threatened native species?

This study analyses the prehistory of a northeastern Siberian population, the Sakha, from both a molecular-genetic and a linguistic perspective.

Promotor: Prof.dr. G.R. de Snoo

How do genetic and environmental factors make us vulnerable to depression?

Research in the group Clinical Neurodevelopmental Studies is focused on understanding and influencing developmental mechanisms in children and adolescents, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders.

Promotor: P.M. Brakefield

Description of Triple bottom line approach for risk-benefit analysis of genetically modified crops.

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

The applications of studying the early development of insects range from agriculture to material science.

Freshwater is an important resource, but at a great risk of species decline due to habitat loss, pollution and over-exploitation, and invasive alien species.

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PhD Defence

What is the population size/structure and distribution of tiger and leopard inside the Bardia National Park (BNP) compared with the population outside? What is the movement and home range and conflict pattern in time and space of tigers and leopards inside the BNP compared with outside? What constitutes…

When children wean off from heavy medication, they often experience withdrawal symptoms. The severity of these symptoms is often difficult to predict. Pharmacologist Bas Goulooze developed a computer model to determine the best weaning strategy for each child. His research has now been published in…

An interdisciplinary team of Leiden researchers has discovered that wasting syndrome, a severe byproduct of tuberculosis, is the same for all humans and animals studied. The discovery offers new opportunities to investigate the still insufficiently understood condition. The scientists also developed…

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

In an innovative study, Radboudumc and LUMC jointly tested a candidate vaccine based on a genetically weakened malaria parasite. The results of this clinical trial, published in Science Translational Medicine, show that the vaccine is safe and elicits a defense response against a malaria infection.

Leiden University Medical Center (LUMC) has spent the past five years coordinating an international study of genetic mutations and breast cancer risks. The results will make it easier to determine which genes increase the risk of breast cancer and to what extent. The researchers published their results…

This thesis describes the genetic and prokaryotic diversity of giant barrel sponges.

It was already known that social anxiety disorder often affects more than one person in the same family. But research by PhD student Janna Marie Bas-Hoogendam has now shown that there are genetic brain characteristics that are associated with social anxiety. The PhD ceremony will take place on 14 Ja…

On 29 June the startup company Future Genomics Technologies will be launched. Its aim is to make DNA technology and research available for businesses faster. Future Genomics Technologies is a collaboration between DNA research laboratory BaseClear and Leiden University.

A collaboration between the IBL and LUMC has resulted in the discovery that the polymerase theta enzyme is essential for the integration of Agrobacterium T-DNA into the genome of plants. The finding means a break-through for the development of more efficient systems for targeted genome modification…

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Promotor: J.M. Memelink

The recognition that there may be more, so-called allosteric binding sites on a given receptor has also fueled our synthetic efforts. Over the last few years we have focused on many drug targets (adenosine A1, A2A and A3 receptors, the mGlu2 receptor and a classic ‘anti-target’, the hERG channel) to…

Cardiovascular disease is the number one cause of death worldwide. The most important risk factor for developing this disease is high cholesterol levels in the blood.

In this thesis, the discovery and optimization is described of chemical tools to study the N-acylethanolamine (NAE) biosynthetic pathway.

Promotor: E. Gittenberger, Co-promotor: B.W. Hoeksema

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

We aim to unravel the molecular mechanisms involved in the transformation of eukaryotic cells by Agrobacterium.