Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

PhD Defence

Lecture

PhD Defence

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

Twenty years from now, the world population is estimated to be around 9 billion people (now 7.8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables, water and energy.…

The long term goal of the Biophysical Organic Chemistry/SSNMR group, headed by Prof. Huub de Groot, is to reach an understanding of structure, dynamics and functional mechanisms of membrane proteins and self-organized biological assemblies and to translate this knowledge into new concepts for nano-devices,…

Efficient gene-targeting during meiosis

A full overview of BPOC/SSNMR PhD theses.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Stakeholder engagement practices are on the rise in regulatory governance. This raises an important question regarding implications for regulatory legitimacy. Engagement mechanisms are not by default legitimizing: Even when initiated to tap into an array of ‘benevolent’ desiderata, unless carefully…

Modelling supra-regional communities in the early 3rd Millennium BC

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

How can citizen science be used to communicate and provide data for social network analysis?

On Wednesday 13 December 2017 René Hage defended his doctoral thesis entitled ‘Handhaving van privaatrecht door toezichthouders’ (Enforcement of private law by regulatory authorities).

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

The Zmapp medicine has been developed with funding from the US government within the framework of the Small Business Innovation Research programme. The European Commission tried to emulate the success of this programme within the EU. Has its effort been adequate and sufficient? Is procurement of research…

The recent terrorist attacks in Europe are presumably not just acts committed by individuals, but acts facilitated by larger jihadist networks. But how do such networks operate? Understanding their modus operandi can be useful knowledge to counter terrorist threats.

PhD Defence

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

On Wednesday 25 January 2017 Esmeralda Vergeer will defend her doctoral thesis Regeldruk vanuit een ander perspectief (Regulatory burden from a different perspective). The supervisor of the research is Professor W.J.M. Voermans.

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

PhD Defence

John van Noort

This dissertation consists of two parts, with the common theme "Exploration on and of Networks".

How and under what conditions Dutch primary school principals' managerial networking activities affect the performance of their school

This project aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Tracing the residues of Neolithic activities through the study of stone artefacts

Promotor: Prof.dr. G.P. van Wezel

Dementia is a progressive disease, diagnosed at a relatively late stage when intervention may not be effective. Aim of the research is to study scans of brain networks to help discover the early network changes related to dementia. Early diagnosis may benefit effectiveness of future treatment.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Promotor: R. Tijdeman, Co-promotor: H.J.J. te Riele

This thesis develops statistical methods for the analysis of high dimensional data: high dimensional networks reconstruction (Chapters 1-4), incorporation of prior information in networks reconstruction (Chapters 2-4), incorporation of prior knowledge in genetic association studies (Chapter 3).

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

In this thesis, we extend the concept of null models as canonical ensembles of multi-graphs with given constraints and present new metrics able to characterize real-world layered systems based on their correlation patterns.

How do we address the pressing challenges posed by large-scale networks?

The role of transnational, non-institutional networks in the opening up of British transatlantic trade at the end of the 17th/beginning of the 18th century