In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

How do plants lure microscopically small 'support teams' into their roots for protection against diseases? And what functions are activated in the microbes and the plants?

What are the genes and molecular mechanisms involved in bacteria-mediated plant drought tolerance?

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Pectin is a plant cell wall polysaccharide made of mainly D-galacturonic acid (GA) subunits. The potency of the filamentous fungus Aspergillus niger to naturally secrete high amounts of pectinases to degrade pectin has been utilized for the industrial production of pectinases.

John van Noort

On Wednesday 25 January 2017 Esmeralda Vergeer will defend her doctoral thesis Regeldruk vanuit een ander perspectief (Regulatory burden from a different perspective). The supervisor of the research is Professor W.J.M. Voermans.

Efficient gene-targeting during meiosis

On Wednesday 13 December 2017 René Hage defended his doctoral thesis entitled ‘Handhaving van privaatrecht door toezichthouders’ (Enforcement of private law by regulatory authorities).

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Müller, Braun & Fraussen examine the conditions under which commissioners appear in the news and which communication strategies they pursue.

This dissertation studies how domestic regulatory agencies and the officials representing them are influenced by and deal with the increasingly complex transnational environments in which they have come to operate. Based on (social) network analysis it demonstrates how decisions of domestic agencies…

Stakeholder engagement practices are on the rise in regulatory governance. This raises an important question regarding implications for regulatory legitimacy. Engagement mechanisms are not by default legitimizing: Even when initiated to tap into an array of ‘benevolent’ desiderata, unless carefully…

PhD Defence

The Zmapp medicine has been developed with funding from the US government within the framework of the Small Business Innovation Research programme. The European Commission tried to emulate the success of this programme within the EU. Has its effort been adequate and sufficient? Is procurement of research…

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

This project aims to explore and examine the factors that impact upon the efficacy of information disclosure duties pertaining to customer data use in online business.

PhD Defence

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Reputation literature has provided crucial insights about the evolution of the US regulatory state. Daniel Carpenter’s influential account painstakingly demonstrates the relevance of reputation to bureaucratic ‘power’ and to early institutional state-building in the US context. We argue that adopting…

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

PhD Defence

The CMCB comprises research groups from the Institute of Biology Leiden (IBL), the Leiden Institute of Chemistry (LIC) and the Leiden University Medical Center (LUMC).

The recent terrorist attacks in Europe are presumably not just acts committed by individuals, but acts facilitated by larger jihadist networks. But how do such networks operate? Understanding their modus operandi can be useful knowledge to counter terrorist threats.

Promotor: Prof.dr. G.P. van Wezel

How do we address the pressing challenges posed by large-scale networks?

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

The Leiden Leadership Centre is an international and interdisciplinary network organization connecting people and perspectives.

The Leiden Complex Networks Network (LCN2) aims at bringing together scientists from different disciplines, based on a common interest in both theoretical models and empirical analyses of networks and graphs.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

For many system in statistical physics the microcanonical and canonical ensemble are equivalent in the thermodynamic limit, but not for all.

Modelling supra-regional communities in the early 3rd Millennium BC

On 6 June 2019, Edward Donelan defended his thesis 'Regulatory Management Policies and a Universal Model for Public Policy Making, Legislative Drafting and Managing Stocks of Legislation'. The doctoral research was supervised by Prof. W.J.M. Voermans.

How can citizen science be used to communicate and provide data for social network analysis?

Below you can find lists of Leiden-based and international organizations working on Central Asia, and an overview of useful resources on Central Asia.

The ‘Food citizens?’ project is assisted by an advisory board, consisting of academics and stakeholders.

LeiCenSAA is dedicated to the study of Ancient Arabia and the sharing of knowledge and expertise on this topic. Thefore it aims to collaborate closely with other research in the field.

The LGBT+ Network offers a platform for all lesbian, gay, bisexual, transgender and queer staff and students at Leiden University.

This dissertation consists of two parts, with the common theme

The focus of this programme is the inter-community social relationships and transformations of island networks in the Lesser Antilles across the historical divide.