Publication by: Anouk Wezel, Sabine Welten, Wida Razawy, Max Lagraauw, Margreet de Vries, Eveline Goossens, Martin Boonstra, Jaap Hamming, Ekambar Kandimalla, Johan Kuiper, Paul Quax, Yaël Nossent and Ilze Bot. Annals of Surgery. 2015;262:841-848.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

On 12 November Ingrid Leijten was a guest on Dutch NOS NPO Radio 1 programme Met het Oog op Morgen. She was asked to speak about the right to freedom of expression.

Combining different disciplines, researchers work together to formulate innovative solutions to societal problems.

Education programmes span the entire spectrum of science ranging from Mathematics and Statistical Science, Computer Science and Data Science, Astrophysics, Physics, Chemistry and Pharmaceutical Science to Biology and Environmental Sciences.

The Corstens Commission that investigated whether there are any grounds for the rumours of antisemitism at the Faculty of Law has found no indication whatsoever for such expressions. This also applies to the professor in question. This is evident from the report that the commission chaired by Professor…

Proactive zebrafish appear to have a much stronger wake-sleep rhythm than reactive fish. In the most reactive fish, rhythmicity appears to be lacking completely. This is shown with research by Leiden biologists, published in December 2018 in the journal BMC Biology.

New research published in the Journal of Leukocyte Biology suggests that these changes to the behavior of the immune system are persistent and can continue even after diet is improvedAlmost everyone knows that improving your eating habits will most likely improve your health. What most people may not…

Dancing in style at the University Sport Centre, and cooking together or visiting the cinema. These two initiatives for bringing Dutch and international students together were the winners of the 2016 Van Bergen Prize. The awards were presented at the annual Diversity Symposium at Leiden University on…

Promotor: P.M. Brakefield

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Netherton Syndrome (NTS) is a rare genetic skin disease caused by mutations in the serine protease inhibitor Kazal-type 5 gene, which encodes the lympho-epithelial Kazal-type-related inhibitor. NTS patients have a profound impaired skin barrier function. Because SC lipids play a crucial role in the…

Streptomyces are multicellular, Gram-positive bacteria in the phylum of actinobacteria which produce a high amount of bioactive natural products of which the expression is tightly coordinated with the life cycle.

How is vegetative development regulated in plants and how does this affect a plant’s life history strategy?

Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.

Our focus is to optimize the fungal cell wall to both increase chitin production and chitin extractability.

In an Advance Online Publication biophysicist John van Noort and others show using magnetic tweezers that DNA is folded in compliant helices of chromatin. This allows enzymes access to the DNA needed for gene expression. Van Noort's research group made the discovery in close partnership with researchers…

Freek Vonk and Mike Richardson, with many collaborators, have published two snake genomes in two parallel articles in the prestigious journal PNAS. Their new findings provide insight into the co-evolutionary arms race between predator and prey.

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

Triple-negative breast cancer (TNBC) constitutes a small subtype (~15%) of breast cancer, but causes the majority of breast cancer-related deaths.

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Mashaghi lab conducts research at the interface of physics, engineering and biomedicine. We develop and use theoretical and experimental approaches to address basic and applied research problems.

Physics and Engineering Approaches to Biomedicine and Pharmacology

Ebru Alazi ‘hacked’ an enzyme-producing system in the fungus Aspergillus niger in order to produce renewable energy more easily. She manipulated the fungus, making it produce more pectinases: enzymes mainly used in the food industry and in the production of renewable energy, such as biofuels. Promotion…

The research master's specialisation Developmental Psychology consists of five main parts: the general courses, the specialisation-specific courses, the elective courses, a research internship and a thesis.

He is said to be one of the greatest living statisticians. Bradley Efron gave a lecture in Marekerk and opened LUXs, the Leiden University Center for Statistical Science, the first university statistics centre in the Netherlands.

Some people are predisposed to develop cancer. Mutations in genetic material that increase a person’s chances of developing cancer can already be present at birth. Researchers are closely examining these mutations to learn more about how cancer begins to develop.

PhD Defence

“Endophenotypes of Social Anxiety Disorder: Can we detect them and are they useful in clinical practice”

Can epigenetic changes explain associations between early life stress and health outcomes?

Advanced fluorescence microscopy techniques have revealed how steroid receptors move inside the nucleus. The results were published by a team from Leiden University and the Erasmus Medical Center in Rotterdam, led by IBL-researcher Marcel Schaaf.

This thesis describes the use of bioorthogonal proteins in immunological settings. It provides an introduction towards the field of protein modification, which was used throughout the thesis for the expression of proteins containing unnatural amino acids.

The Europa Institute has invited Dorjana Bojanovska from Macedonia to visit Leiden Law School to conduct her master thesis research from 6 March - 31 March 2017. Dorjana is a student at the Comparative Constitutional Law program at the Legal Studies Department of the Central European University. The…

Carl Li defended his thesis on 30 June 2015

Can zebrafish provide a fast, sensitive in vivo vertebrate model for identifying novel mechanisms of Ewing sarcoma progression and for development of new anticancer compounds in a time- and cost-effective manner?

The genetic information of all living organisms is contained in their DNA. Cells modify the degree of DNA compaction by epigenetics, which largely determines what genes are read out and which genes are transcriptionally silent.

Publication by: Vanessa Frodermann, Janine van Duijn, Gijs van Puijvelde, Peter van Santbrink, Max Lagraauw, Margreet de Vries, Paul Quax, Ilze Bot, Amanda Foks, Saskia de Jager and Johan Kuiper. Journal of Internal Medicine. 2016;279:592-605.