2,214 search results for “gene editing” in the Public website
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mutagenesis to identify breast cancer drivers and therapy resistance genes in mice
In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.
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Strategies for the improvement of genome editing in Arabidopsis thaliana
Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.
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Gene regulation in embryonic development
The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.
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Chromatin dynamics in single genes
John van Noort
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Efficient gene-targeting during meiosis
Efficient gene-targeting during meiosis
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Horizontal gene transfer and spreading of biosynthetic gene clusters and antimicrobial resistance
Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.
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Agrobacterium-mediated protein therapy for genome editing
Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?
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Tom van der Wel
Science
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Translation & editing
The Academic Language Centre interpreting and translation service has extensive experience in translating to and from Dutch and English. Our services are characterised by professionalism, quality, and reliability.
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Exploring Grainyhead-like 2 target genes in breast cancer
The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.
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Image analysis for gene expression based phenotype characterization in yeast cells
Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek
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Earlier editions
The Summer School in Languages and Linguistics has been a regular event on the Leiden Centre for Linguistics calendar for over 14 years.
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ERC funded Postdoc – Molecular Biologist – gene control with synthetic tools
Science, Leiden Academic Centre for Drug Research (LACDR)
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TARGETBIO: Transmission of Antimicrobial Resistance Genes and Engineered DNA from Transgenic Biosystems in Nature
This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.
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Precision modeling of breast cancer in the CRISPR era
The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.
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Identification and characterization of developmental genes in streptomyces
Promotor: Prof.dr. G.P. van Wezel
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Special edition Information Polity
In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.
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interplay between local three- dimensional chromatin architecture and gene expression
Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.
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The role of the Arabidopsis AHL15/REJUVENATOR gene in developmental phase transitions
This thesis describes the functional analysis of the Arabidopsis AHL15 gene.
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PhD student / post-doc researcher in Quantitative transcriptional gene network analysis in systems toxicology.
Science, Leiden Academic Centre for Drug Research (LACDR)
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analysis of Dof transcription factors controlling heading date and PPDK gene expression in rice
Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang
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Unravelling the genes responsible for life history traits in the giant woody cabbage (Brassica oleracea)
Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?
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Targeting for success: Mechanistic insights into microRNA-based gene therapy for Huntington disease
PhD defence
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PhD candidate in Bioinformatics Safety Assessment of Gene and Cell Therapy
Science, Leiden Institute of Chemistry (LIC)
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EU Banking and Insurance Insolvency (second edition)
Just Published: EU Banking and Insurance Insolvency (second edition) Authored and Edited by Gabriel Moss QC, Bob Wessels and Matthias Haentjens Published by Oxford University Press
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Chemical genetic approaches for target validation
Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.
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Functional characterization and unraveling the Gene Regulatory Networks (GRNs) of HD-Zip transcription factor HB40 (and HB22) in Arabidopsis
In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.
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Freedom of additional signals on genes: on the combination of DNA mechanics, genetics and translation speed
DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.
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A time-space translation mechanism for patterning the vertebrate anteroposterior axis
My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.
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Chemical genetics strategy to profile kinase target engagement reveals role of FES in neutrophil phagocytosis, Nat. Comm. 2020
Chemical tools to monitor drug-target engagement of endogenously expressed protein kinases are highly desirable for preclinical target validation in drug discovery. Here, we describe a chemical genetics strategy to selectively study target engagement of endogenous kinases.
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Novel role of the AT-HOOK MOTIF NUCLEAR LOCALIZED 15 gene in Arabidopsis meristem activity and longevity
Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.
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Sixth edition of the European Cyber Security Perspectives
On 12 March 2019, KPN published the sixth edition of the European Cyber Security Perspectives. Sergei Boeke, researcher at the Institute of Security and Global Affairs, has written an article about Cyber Warfare.
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The Law of the European Union, Fifth Edition
The Law of the European Union is a complete reference work on all aspects of the law of the European Union, including the institutional framework, the Internal Market, Economic and Monetary Union and external policy and action.
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Introduction to Medieval Europe 300–1500, Third Edition
Introduction to Medieval Europe 300–1500 provides a comprehensive survey of this complex and varied formative period of European history, covering themes as diverse as barbarian migrations, the impact of Christianisation, the formation of nations and states, the emergence of an expansionist commercial…
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Critical edition and annotated translation of the Niśvāsamukha
This project will lead to a critical edition and annotated translation of the Niśvāsamukha, the opening book of the Niśvāsatattvasaṃhitā.
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Gene networks-based mechanistic assessment of drug-induced organ toxicity: a focus on liver and kidney
Drug induced organ toxicity is the main problem of the drug development and drug usage in the clinic. The liver and kidneys are the most sensitive organs towards drug induced toxicity.
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is gold: impacts of local FoxP1 knockdowns on auditory perception and gene expression in female zebra finches
The experiments described in this thesis employ local lentiviral knockdowns in brain areas of female zebra finches followed by behavioural assays consisting of preference and Go/Nogo tasks.
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Leiden researchers discover genes that affect spread of breast cancer
Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…
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live longer? Leiden physicist makes discovery in protective layer in genes
With the aid of physics and a minuscule magnet, researchers have discovered a new structure of telomeric DNA. Telomeres are sometimes seen as the key to living longer. They protect genes from damage but get a bit shorter each time a cell divides. If they become too short, the cell dies. The new discovery…
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Longevity gene discovered in plants
Harvesting rice from the same field, without planting new rice plants? A discovery may bring this scenario closer. Leiden scientists have discovered a gene that allows annual plants to grow after flowering, instead of dying. Publication on 13 April in Nature Plants.
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The Paippalādasaṁhitā of the Atharvaveda, Kāṇḍa 15: A New Edition with Translation and Commentary
The aim of this dissertation is to present a critical edition of kāṇḍa 15 of the Paippalādasaṁhitā (PS) of the Atharvaveda.
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Natalis, De secundis intentionibus, Distinctiones I&II : Critical Edition with Introduction and Indices
This critical edition covers the first two parts of De secundis intentionibus by Hervaeus Natalis (14th century).
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Exploring novel regulators and enzymes in salicylic acid-mediated plant defense
Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.
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Modulation of plant chemistry by rhizosphere bacteria
Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.
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Phyto-pharmaceuticals and gene targeting
We exploit secondary metabolites of plant to develop pharmaceutical compounds and we genetically modify plant genomes to improve crops.
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Regulation on Insolvency Proceedings: An Introductory Analysis (Fourth Edition)
This book, written by two representatives of Leiden Law School, describes the framework of the European Insolvency Regulation (recast) (‘EIR Recast’), in force since June 2017.
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What plant genes can teach us
Just like us, plants also produce growth hormones, and they also go through an ageing process. The study of the genes and mechanisms behind these processes is useful not only for crop breeding and agriculture, but also for medical research. That is the view held by Professor of Plant Developmental Genetics…
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Packaging and accessing DNA molecules
Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.
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Advocating for gene therapies for rare diseases
‘If we don’t start talking about this, who else will?’ This is what Arjan Lankester, paediatrician/immunologist at the Leiden University Medical Center (LUMC) and Professor of Paediatrics, thought when it seemed that various extremely effective gene therapies for rare diseases would no longer be available…
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Linking the gene regulatory network with the functional physical structure of whole-genome engineered Arabidopsis mutants : an HR-MAS NMR-based
Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.