In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Increasing the efficiency of gene targeting (GT) as a genome editing tool in plants has been an important goal in plant biotechnology.

John van Noort

Efficient gene-targeting during meiosis

Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Is translocation of nucleases possible via Agrobacterium T4SS and is it efficient enough for mutagenesis?

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

The Academic Language Centre interpreting and translation service has extensive experience in translating to and from Dutch and English. Our services are characterised by professionalism, quality, and reliability.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

The Summer School in Languages and Linguistics has been a regular event on the Leiden Centre for Linguistics calendar for over 14 years.

The molecular mechanisms that instigate a healthy cell to become malignant are fueled by (epi)genetic alterations in so-called driver genes.

Promotor: Prof.dr. G.P. van Wezel

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

In this special edition of Information Polity there is a focus on the transparency challenges of using algorithms in government in decision-making procedures at the macro-, meso-, and micro-levels.

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Just Published: EU Banking and Insurance Insolvency (second edition) Authored and Edited by Gabriel Moss QC, Bob Wessels and Matthias Haentjens Published by Oxford University Press

Drug development is a time- and resource-consuming process that starts with the discovery and validation of a (protein) target that contributes to pathogenesis or disease progression.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

The Law of the European Union is a complete reference work on all aspects of the law of the European Union, including the institutional framework, the Internal Market, Economic and Monetary Union and external policy and action.

On 12 March 2019, KPN published the sixth edition of the European Cyber Security Perspectives. Sergei Boeke, researcher at the Institute of Security and Global Affairs, has written an article about Cyber ​​Warfare.

Introduction to Medieval Europe 300–1500 provides a comprehensive survey of this complex and varied formative period of European history, covering themes as diverse as barbarian migrations, the impact of Christianisation, the formation of nations and states, the emergence of an expansionist commercial…

This project will lead to a critical edition and annotated translation of the Niśvāsamukha, the opening book of the Niśvāsatattvasaṃhitā.

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

Harvesting rice from the same field, without planting new rice plants? A discovery may bring this scenario closer. Leiden scientists have discovered a gene that allows annual plants to grow after flowering, instead of dying. Publication on 13 April in Nature Plants.

The aim of this dissertation is to present a critical edition of kāṇḍa 15 of the Paippalādasaṁhitā (PS) of the Atharvaveda.

This critical edition covers the first two parts of De secundis intentionibus by Hervaeus Natalis (14th century).

We exploit secondary metabolites of plant to develop pharmaceutical compounds and we genetically modify plant genomes to improve crops.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Just like us, plants also produce growth hormones, and they also go through an ageing process. The study of the genes and mechanisms behind these processes is useful not only for crop breeding and agriculture, but also for medical research. That is the view held by Professor of Plant Developmental Genetics…

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

This book, written by two representatives of Leiden Law School, describes the framework of the European Insolvency Regulation (recast) (‘EIR Recast’), in force since June 2017.

Our DNA molecules are packaged by proteins in compact structures. The aim of this project is to understand how modern gene editing techniques nevertheless get access to their target in the DNA.

PhD student Esmee Koedoot studied the underlying processes responsible for metastases in a dangerous type of breast cancer. She hopes to find new possibilities to fight the disease. In December 2019 she obtained her doctorate cum laude.

Plant researchers have been wrong for years about how plant growth and development are regulated, as Yao Xiao pointed out during his PhD project. They overlooked the role of a protein that turns out to be essential, just as it is in the development of animals and yeasts. In plants, it regulates the…

Leiden biologists have shown that a gene present in plants, animals and yeasts does play an important role in plants, although for years the gene was considered unimportant. It turns out the gene plays a crucial role in the development of vascular tissue in plants. Publication in Nature Plants on 11…

The way genes are folded determines their activity in our body. Leiden biophysicists are now the first to unravel this structure molecule-by-molecule. Publication on December 1st in Nature’s Scientific Reports.

A publication in Nature Plants by a team of Leiden biologists has received national and international media attention. The researchers can have annuals flower multiple times thanks to a particular gene they discovered.

Have you ever wondered what makes immigrants legally different no matter which legal system they have moved into and no matter what rights have been granted there? Have you ever wondered why immigrants are considered ‘the other’ despite claims that their ‘integration’ and non-discrimination is a top…

Master's student Thalia Luden receives an NWO grant for her research proposal about a gene that brings flowering plants back into a growth phase. Companies in floriculture and vegetable seed breeding also contribute to the research.

In a publication in Science, Noam Zelcer from the Division of Biopharmaceutics describes a previously unrecognized pathway to regulate LDL-cholesterol levels. He is also able to modulate this pathway. This opens the possibility for complementing and improving the efficacy of statins: A class of drugs…

Just published:

On the 11th of June, Umberto Selva successfully defended his doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Umberto on this great result.

Researchers and clinicians at Leiden University Medical Centre (LUMC) are about to begin a milestone clinical study. It will be the first time a stem cell gene therapy developed in the Netherlands is used in a clinic. The therapy will be used to treat children with SCID, a rare disorder where children…

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