Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

The human body consists of hundreds, perhaps thousands of different types of cells, each with different morphologies and functions, despite having the same genome.

Promotor: Prof.dr. H.J.A. Rottgering, Co-promotor: David Sobral

Soil is a home for an unbelievable diversity and abundance of microbial life that is essential for supporting life on our planet.

John van Noort

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

In this book, Sarah Giest, Assistant Professor at the Institute of Public Administration, provides insight into the collaborative and absorptive capacities needed to provide public support to local innovation through cluster organizations.

Promotor: Prof.dr. G.P. van Wezel

Efficient gene-targeting during meiosis

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Perform cutting-edge research in the area of the STAR mathematics cluster.

The renovation of Cluster Zuid (P.N. van Eyckhof-Van Wijkplaats) is the third project in the redevelopment of the Humanities Campus. With the renewal of these buildings, the university ensures a sustainable campus with modern facilities. The university wants to create an attractive educational environment…

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

My PhD research is devoted to studies of the conjectural cluster-algebraic symmetry in the theory of topological string, which is the simplest, however already non-trivial sector in the theory of string.

CADS researchers give methodology their own unique signature through two parallel engagements: (a) teaching and researching the full range of social science methods, from audio-visual engagements, through global ethnography, to statistical analysis; and (b) interrogating these multiple modalities employing…

The CADS Research Cluster Diversity aims to further theoretical and methodological debates on the classifications of human difference, such as gender, race, ethnicity, sexuality, class, age, ability, religion, level of development, time, etc., and the way these classifications organize social life.

The CADS Asia Research Cluster extends the legacy of the Institute’s Asia focus into the future, as an important hub in international networks on the study of Asia and through active engagement with colleagues in Asia. Within the Institute the Asia Research Cluster offers a platform for anthropologists…

Actinobacteria are Gram-positive bacteria that have a complex multicellular life cycle and are well known for their ability to produce a wide range of bioactive natural products (NPs).

The d12n Research Cluster provides a space for inquiry and intervention into the ongoing digit(al)isation of culture, society, and scholarship. The research cluster aims to link CADS Institute researchers to each other as well as to experts and praticioners from around the world as we combine thinking…

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

The Sustainability Research Cluster fosters dialogue and collaboration among anthropologists and sociologists researching aspects of socio-cultural, ecological, and economic sustainability in and affiliated with the Institute of Cultural Anthropology and Development Sociology. It also seeks to stimulate…

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Can new variants of daptomycin and the polymyxins be found?

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: Dr. H.Hoekstra

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In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

This project focuses on a striking parallelism between two macro-groups of languages: southern Italian dialects and the so-called split-ergative languages, like Basque, Georgian, Dyirbal, Hindi/Urdu.

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

Science, Leiden Academic Centre for Drug Research (LACDR)

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

Nucleoid associated proteins maintain the architecture of the bacterial chromosome and regulate gene expression, hinting that their role as transcription factors may involve local three-dimensional chromosome re-modelling.

In this thesis,

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Science, Leiden Academic Centre for Drug Research (LACDR)

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

Which genes are involved in woodiness and associated traits such as drought tolerance, flowering time, stem elongation, life span, and plant herbivory, and how do these gene regulatory pathways overlap?

Promotor: G.P. van Wezel

PhD defence

Bacterial biocatalysis constitutes a sustainable alternative for high-value chemicals production by enabling the utilization of renewable feedstocks.

Science, Leiden Institute of Chemistry (LIC)

PhD defence

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

DNA carries various forms of information. Out of these forms of information the most well-known is classical genetic information.