Biosynthetic gene clusters (BGCs) for natural products are widespread in microbial genomes, and they are rapidly exchanged. This research assesses the factors that control the spread of BGCs and resistance genes in nature. This includes risk assessment for the spread of engineered DNA in nature.

Promotor: G.P. van Wezel, Co-promotor: Y.H. Choi

Promotor: Prof.dr. G.P. van Wezel

Can a new proteomics workflow be developed to link genes and gene clusters to bioactive molecules, identify novel compounds and enhance the production in the Streptomyces lividans enzyme?

Efficient gene-targeting during meiosis

Promotores: T.H.W. Bäck, A. Plaat, Co-promotor: F.J. Verbeek

Promotor: Prof.dr. H.J.A. Rottgering, Co-promotor: David Sobral

Promotor: G.P. van Wezel

Promotor: Prof.dr. K.H. Kuijken, Co-Promotor: Dr. H.Hoekstra

This thesis focuses on the X-ray spectral analysis of merging galaxy clusters and the plasma code development for future high-resolution X-ray spectroscopy observations.

Promotor: Jelle S. Kaastra Co-promotor: Jelle de Plaa

In this thesis, we used genetically engineered mouse models to identify genes and pathways that are involved in ILC formation and in the development of resistance to FGFR-targeted therapy.

This monograph focuses on clustering of objects in high-dimensional data, given the restriction that the objects do not cluster on all the attributes, not even on a single subset of attributes, but often on different subsets of attributes in the data.

This project aims to assess the risk of spread of antimicrobial resistance genes in the environment derived from currently used synthetic biology approaches in the field of drug discovery.

In the research programme Microbial Sciences we perform state-of-the-art research in the field of biotechnology and microbial sciences.

In this thesis, I study the formation of large-scale structure and the physics of particle acceleration at large scales (~Mpc).

Promotor: Koen Kuijken Co-promotor: Henk Hoekstra

A galaxy is already incredibly large, but it can get even bigger. Astronomer Reinout van Weeren investigates clusters of galaxies, one of the largest structures in the universe. For his research into the origins and evolution of these clusters, he obtained an ERC Starting Grant of 1.5 million euros.…

We aim to unravel the complex and intertwining regulatory systems that control development and antibiotic production in streptomycetes.

Leiden University is partner of the Netherlands Centre for One Health (NCOH). This initiative brings together leading academic research institutes in the Netherlands in an open innovation network that responds to the theme: One Health. NCOH interviewed Doris van Bergeijk: PhD student of the project…

The renovation of Cluster Zuid (P.N. van Eyckhof-Van Wijkplaats) is the third project in the redevelopment of the Humanities Campus. With the renewal of these buildings, the university ensures a modern campus that offers space to the growing faculty. The university wants to create an attractive educational…

This project focuses on a striking parallelism between two macro-groups of languages: southern Italian dialects and the so-called split-ergative languages, like Basque, Georgian, Dyirbal, Hindi/Urdu.

PhD Defence

The objective of this study was to investigate the expression and function of GRHL2 in different breast cancer subtypes.

Researchers at Leiden University have mapped genes that cause breast cancer cells to migrate. The Leiden toxicologists Professor Bob van de Water, Dr Wies van Roosmalen, Dr Sylvia E. Le Dévédec and colleagues studied 1500 individual genes. They found eight, including the SRPK1 gene, that regulate the…

Perform cutting-edge research in the area of the STAR mathematics cluster.

PhD Defence

John van Noort

In this thesis, "culture" refers to the collection of subjective human traits, such as preferences an opinions, that a given, geographically bounded population has at a given moment in time.

My PhD project studies how the temporally sequential Hox gene expression is regulated during head-tail patterning of the frog embryo.

This thesis describes the functional analysis of the Arabidopsis AHL15 gene.

Plant-microbe interaction resulted in different physio/chemical responses by host plant and interacting rhizobacteria.

Salicylic acid (SA) is a plant hormone, which is involved in the defense responses to pathogens and to abiotic stress, and in the regulation of plant growth and development.

Plant architecture has distinct forms in different plant species, but also within a species the finalarchitecture of a plant is determined by its gradual development and changes therein induced by environmental conditions during the plant’s life cycle.

Which genes are involved in woodiness and associated traits such as drought stress resistance, flowering time, stem elongation, life span, and plant herbivory, and how do these QTLs overlap?

Promotor: D. Bouwmeester, Co-promotor: D. Kraft

On Monday the 8th of December, the annual symposium of the IBL will be organized at the main building of the LUMC Leiden. This year’s theme is “Integrative Biology towards Healthy Communities”.

We exploit secondary metabolites of plant to develop pharmaceutical compounds and we genetically modify plant genomes to improve crops.

PhD student Esmee Koedoot studied the underlying processes responsible for metastases in a dangerous type of breast cancer. She hopes to find new possibilities to fight the disease. In December 2019 she obtained her doctorate cum laude.

On October 31st, Margarita Gulian succesfully defended her doctoral thesis and graduated. The Leiden University Centre for Linguistics congratulates Margarita on this great result.

Promotor: P. T. de Zeeuw, Co-promotor: N. Neumayer; G. van de Ven

Promotor: J.N. Kok, Co-Promotor: A.J. Knobbe

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

Simon Portegies Zwart, professor of Computational Astrophysics, uses computers to simulate the evolution of stars. We speak with him about his field and about the challenges of working with huge amounts of complex data.

Starting from September, the four Dutch mathematics clusters DIAMANT, NDNS, GQT and STAR will each be given 1 ME from NWO Exact Sciences, to be spent within a period of two years.

Climate change is a challenge for both current and future generations. New biological resources have to be developed in order to meet the demand for energy as well as the demand for food.

ALICE is Leiden University's newest computing miracle. The computing cluster is a first step in the development of infrastructure for computational and data-intensive research that is accessible to everyone within Leiden University and the LUMC. This includes both experienced users of high-performance…

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

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