A century ago, it was unclear whether the stars in the sky were clustered in groups, or widely spread in the universe.

For centuries astronomers studied the Universe by collecting light. Nowadays, we are living in times of great technological advancements, which allow us to explore our Universe in a new way - though gravitational wave radiation.

Promotor: W. Jaffe, Co-promotor: K. Meisenheimer

It is a common technique in global optimization with expensive black-box functions to learn a surrogate-model of the response function from past evaluations and use it to decide on the location of future evaluations.

Historiography of science is in its current self-image a non-evaluative discipline. Its main goal is to understand past processes of knowledge formation on their own terms. In the last few decades this approach has greatly improved our understanding of the phenomenon of science. Yet, something strange…

Microneedle-based vaccination has several advantages over vaccination by using conventional hypodermic needles.

Chemical biology research at the Leiden Institute of Chemistry is aimed at understanding biological processes at the molecular level to strengthen the knowledge base of human health and disease. The approach to achieve this goal is a fundamental chemical one; with the aid of chemical probes biological…

Twenty years from now, the world population is estimated to be around 9 billion people (now 7.8 billion). In combination with the improvements in living standards and the corresponding growth in consumption, this will result in an enormous increase in the demand for food, consumables, water and energy.…

Promotor: M. de Jong, Co-Promotor: Samtleben

Through metabolism, biochemical processes give rise to the complexity of life. Acquired and inborn errors in metabolism underlie many diseases occurring in man. The challenge for present day medical biochemistry is to find, and integrate, pieces of information at molecular, cell and organismal level…

Arts and leisure , Arts and leisure

Recently Cambridge University Press published dr. Jan Osters monograph “Media Freedom as a Fundamental Right”.

The high velocity tail of the total velocity distribution of stars provides essential insight into fundamental properties of the Galaxy.

What opportunities and threats flow from the existence of institutional and normative diversity in the area of fundamental rights for the effective protection of those rights in a pluralist world?

Poly(lactic-co-glycolic acid) (PLGA) particles have been extensively studied as biodegradable delivery system to improve the potency and safety of protein-based vaccines. In this study we analyzed how the size of PLGA particles, and hence their ability to be engulfed by dendritic cells (DC), affects…

Overkleeft

Galaxies are environments where gas coalesces, cools, and is converted into stars. However, it remains unclear the exact mechanisms through which galaxies acquire, redistribute and lose their gas.

Promotor: Prof.dr. H. J. A. Röttgering, Co-Promotor: Dr. M. Haverkorn

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

This thesis presents pioneering work on the panchromatic emission of some of the most luminous galaxies in the early Universe: star forming galaxies and active galactic nuclei.

This thesis describes biochemical investigations of glucocerebrosidase (GBA), the lysosomal β- glucosidase that is deficient in Gaucher disease (GD).

The studies described in this thesis deal with glycosidases, in particular alpha-galactosidases.

How can we develop new chemical biology tools and approaches to understand and interfere with glucosylceramide metabolism in relation to Gaucher disease?

Why do we need fundamental science? For a lot of reasons, speakers showed at the Lustrum Symposium ‘Science Matters’. This symposium was held on 18 March 2016 to celebrate the 200th anniversary of the Faculty of Science.

Promotor: Prof.dr. K.J. Batenburg

On 22 September, the Social Justice Expertise Center and the Dutch Association on Labor Rights (VVA) brought together eighty (Dutch) labor law lawyers to discuss the relationship between corporate social responsibility (CSR) and fundamental labor rights.

In this thesis, the research focuses on the properties of dark matter and dark matter haloes and how they connect with the galaxies we can observe in the Universe.

This dissertation investigates A'-dependencies in Standard German, Zurich German and Dutch where the dislocated constituent is indirectly, i.e. not transformationally, related to the position where it is interpreted. The analysis is carried out within the Principles & Parameters framework.

Promotor: W. Jiskoot, Co-promotor: H.A. Every

‘Free-market economics has reduced the value of higher education to a question of efficiency and productivity,’ says Sarah de Rijcke. And, she adds, there is no clear description of what we actually want scientific research to achieve. Inaugural speech on Friday 17 May.

In this thesis, we present new laboratory data of interstellar dust analogues.

Poama and Theuns co-wrote an opinion piece on why voting in prison should be mandatory worldwide. It appeared on National Interest's website on February 12.

In what ways do matters of cybersecurity affect the relationship between governments and citizens, have a bearing on (fundamental) rights and civil liberties, and alter the role and responsibilities of governments?

On 22 April 2016, the Social Justice Expertise Center (SJEC) hosted the first global conference for international labour law judges and other adjudicators themed ‘Ensuring Coherence in Fundamental Labour Rights Case Law: Challenges and Opportunities’ at the Academy Building of the University of Leid…

This collaborative project aims to explore the history of the concept “barbarism” in Europe from the 18th century to the present, with a particular emphasis on the role of literature and art in the concept’s shifting functions.

On April 7th, the February 2017 cohort of the MSc specialisation Science Based Business successfully completed the Management Fundamentals course.

The League of European Research Universities (LERU) calls for greater appreciation of fundamental research that does not have an immediate application. A working group headed by Geert de Snoo, dean of the Leiden Faculty of Science, issued a memorandum on the subject on 29 August.

Promotor: K. Kuijken, Co-Promotor: H. Hoekstra

Rossi

The Graduate School of Science has a centuries-old tradition in cutting edge education and research in science.

Researchers at Leiden Observatory study the fundamental physics that creates structure in the Universe. These processes collect matter into galaxies and gas into stars. With the use of powerful telescopes and advanced calculations and computer simulations, Leiden astronomers seek to understand the origin,…

Researchers at Leiden Observatory study the fundamental physics that creates structure in the Universe. These processes collect matter into galaxies and gas into stars. With the use of powerful telescopes and advanced calculations and computer simulations, Leiden astronomers seek to understand the origin,…

Leiden Professor Marc Koper will be carrying out research on the chemical process underlying tin coating in order to optimise the quality of tin coatings. He has been awarded a subsidy of 285,000 euros from the STW Technology Foundation and Tata Steel.

With the energy transition toward a renewable energy supply and a CO2-neutral economy, electrification of the energy system is rising in importance, which leads to the challenge of long-term storage of renewable electricity.

PhD Defence

PhD Defence

A former employee of Leiden University breached academic integrity. This is the conclusion of the University’s Academic Integrity Committee in its recommendation to the Executive Board on 11 January 2019.

GLOBOX is a spatially differentiated multimedia fate, exposure and effect model. It is used for the calculation of spatially differentiated LCA characterisation factors on a global scale.