3128 search results for “g protein-coupled receptor” in the Public website
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Salma BalazadehWiskunde en Natuurwetenschappen
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Activity-based protein profiling and bio-orthogonal chemistry
Conference
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NWO ECHO grant for research on fickle RNA production
Genes are active sometimes, and other times they remain dormant for a while. Leiden physicist John van Noort receives an NWO ECHO grant to find out how this happens.
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Chemical Biology Lecture: Carbohydrate-binding Proteins as Targets for Anti-Infectives and Diagnostics
Lecture
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Leiden iGEM students win prize with squid protein
The Leiden students who participated in the iGEM synthetic biology competition have won the prize for best production. They developed a way to have bacteria produce the substance suckerine, a protein derived from the Humboldt squid. By doing so, they want to help heal burn wounds. ‘The announcement…
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Imaging of alkyne-functionalized ruthenium complexes for photoactivated chemotherapy
In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.
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Heme biosynthesis and regulation in the filamentous fungus Aspergillus niger
Promotors: Prof.dr. P.J. Punt, Prof.dr. C.A.M.J.J. van den Hondel
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Targeting Human Proteasomes: Substrates, Inhibitors and Prodrugs
Large parts of the research described in this Thesis aims at the development of oligopeptide-masked toxins and their in situ immunoproteasome-mediated activation.
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G.F. Stout and the Psychological Origins of Analytic
The philosopher and psychologist G.F. Stout was the teacher of Moore and Russell around 1894. This book shows that Stout's ideas have played a role in Moore and Russell's development from their early idealism towards analytic realism, where Stout's ideas often find their origin in early phenomenolog…
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The Use of Activity-Based Protein Profiling to Study Proteasome Biology
PhD Defence
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Applications for activity-based probes in biomedical research on glycosidases
Lysosomal glycosidases are acid hydrolases that fragment glycoconjugates in lysosomes.
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Student team hopes to heal skin with squid protein
Eleven ambitious Leiden students hope to heal burns with a special substance from squid teeth. They are taking part in the international iGEM competition. They need to raise almost 10,000 euros to fund their project this summer.
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Unwinding a hank of yarn: how do cellular machines unfold misfolded proteins?
Protein chains typically fold to function. Folding is a complex process and if done correctly leads to a unique functional fold topology for a given protein chain. Other topologies are also possible but are often non-functional or toxic. These misfolded proteins are then unfolded and subsequently refolded…
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The RNA-binding protein Quaking in vascular health and disease
PhD Defence
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Activity-based protein profiling of glucosidases, fucosidases and glucuronidases
PhD Defence
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Sticky & Dirty Proteins
PhD Defence
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Structural characterization of bacterial proteins involved in antibiotic resistance and peptidoglycan biosynthesis
PhD Defence
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Decomposing tears in order to detect Dry Eye Disease
By measuring proteins in tears, ophthalmologists can more easily diagnose dry eyes (Dry Eye Disease). Peter Raus, a Belgian ophthalmologist and PhD student at the Institute of Biology Leiden, developed a new method for protein determination in tear fluid. The technique is also promising for the early…
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New cellular imaging paves way for cancer treatment
A new technique using fluorescent imaging to track the actions of enzymes might aid drug design for new anti-cancer, inflammation and kidney disease treatments. Researchers at the University of York and Leiden University have published these findings in Nature Chemical Biology.
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applications of paramagnetic NMR spectroscopy for protein research
PhD Defence
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Pharmaceutical Aspects of Subvisible Particles in Protein Formulatins
PhD Defence
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Mass spectrometry based protein profiling
PhD Defence
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Chemical tools to study the cannabinoid receptor type 2
PhD Defence
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Tailoring adjuvant therapy for hormone receptor-positive early breast cancer
PhD Defence
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Mass spectrometry based protein profiling
PhD Defence
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FRESH Lecture: NikA as versatile protein scaffold for the design of artificial oxidases/oxygenases for sustainable chemistry
Lecture
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Jelle van Buuren and Dennis Broeders on 5G: Technological Dangers and European Chances
The 4G network will soon be replaced by 5G. 5G will enable users to set up faster and more reliable data links as well as better privacy protections. For intelligence agencies, however, the upgrade in data protections will create huge problems.
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Microbial Chemotaxis
In order to gain insight into the structure and function of the molecular complexes involved in chemotaxis, we use electron cryotomography (ECT). This technique allows us to directly study microbes in their native state at resolutions capable of visualizing individual proteins.
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Research Grant for tuning into photosynthesis
Biophysicist Anjali Pandit has been awarded a FOM 'Projectruimte' research grant for her proposal ‘Tuning into the photosynthetic membrane with atomistic precision’.
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Advances in GPCR Modeling Evaluated by the GPCR Dock 2013 Assessment: Meeting New Challenges
Source: Structure , Volume 22, Issue 8, pp. 1120-1139 (2014)
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Same-sex couples in Europe: more rights in more countries
Launch database
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Maria van der SchaarFaculty of Humanities
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Quantitative live cell imaging of glucocorticoid receptor dynamics in the nucleus
PhD Defence
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Toll-like receptor signaling in the innate immune system of zebrafish larvae
PhD Defence
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to insurmountability: Novel avenues to better target CC Chemokine receptors
PhD Defence
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in zebrafish caudal fin regeneration: differential requirement for protein-tyrosine phosphatases
PhD Defence
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Regulation of Target Proteins by Small Ubiquitin-like Modifiers
PhD Defence
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Innovation and Tradition: The Odd Couple
Debate
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Design, synthesis and application of paramagnetic probes for protein structure studies
PhD Defence
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FRESH Lecture: CO2 splitting by inductively-coupled hybrid plasma catalysis and Boudouard reactions
Lecture
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Controlling growth and morphogenesis of the industrial enzyme producer Streptomyces lividans
Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom
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Jaap de Hoop Scheffer on the position of Europe during the G20 summit in Osaka
Jaap de Hoop Scheffer, Professor International Relations and Diplomatic Practice at the Institute of Security and Global Affairs at Leiden University spoke to Belgian (Flemish) news magazine Knack about the position of Europe in relation to the United States and China. ‘Europe has to be careful to avoid…
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The Effects of Breast Cancer Therapy on Estrogen Receptor Signaling Throughout the Body
PhD Defence
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Anti-Carbamylated protein antibodies in Rheumatoid Arthritis
PhD Defence
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Activity-based Protein Profiling of the Diacylglycerol Lipases
PhD Defence
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Functional analysis of Agrobacterium tumefaciens virulence protein VirD5
PhD Defence
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Activity-based protein profiling in drug discovery
PhD Defence
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Fluorescence Polarization Activity-Based Protein Profiling on Retaining Glycosidases
PhD Defence
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Feodor-Lynen research fellowship for Bela Bode
Dr Bela Bode receives a Feodor Lynen research fellowship for postdoctoral researchers by the Alexander von Humboldt-Foundation for development of new methods for signal enhancement in solid state NMR. He aims to create a specific analytical tool for surface studies and research on membranes and membrane…
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Two Leiden astronomers awarded with prestigious IAU PhD Prize
Two Leiden astronomers will receive the prestigious IAU PhD Prize. Both Jorryt Mathee and Niels Ligterink of the Leiden Observatory won a prize. Scientific director Huub Röttgering: We are proud that this year two of our PhD students receive an IAU prize for the best thesis in their field of researc…