Zebrafish is an excellent model organism for studying various human diseases. Due to opaqueness of the adult phase, in vivo studies are restricted to early embryonic stages. This raises the need for rapid sensitive and non-invasive in vivo imaging methods to follow developmental processes, not only…

Promotor: H.J.M. de Groot, Co-Promotor: A. Alia

Alzheimer's disease (AD) is the most frequent neurodegenerative disorder and the primary cause of dementia. The neuropathological features of AD include the occurrence of senile plaques, neurofibrillary tangles, decreased synaptic density, and loss of neurons. An obstacle in the study and treatment…

In this thesis, we show how MRFM can usefully contribute to the field of condensed-matter.

Promotor: T.H. Oosterkamp

Promotores: Prof.dr. J. Aarts, Prof.dr. J.M. van Ruitenbeek

A network combining 9 academic research groups and 4 collaborating industrial companies will train the next generation of PhD students and post-doctoral researchers, in developing and applying novel experimental and theoretical methods in the NMR spectroscopy of systems containing paramagnetic metals.…

Promotor: H.J.A. Röttgering, Co-promotor: M. Haverkorn

Promotor: Prof.dr.ir. J.W.M. Hilgenkamp, Prof.dr. J. van den Brink

Promotor: S.M. Verduyn Lunel

In photoactivated chemotherapy (PACT), a biologically active compound is caged by a light-cleavable protecting group.

In this thesis, I studied the origin and evolution of the non-thermal radiation in merging galaxy clusters.

The main focus of this thesis is the behaviour of two-dimensional materials, namely (anti)-ferromagnetic materials in the first two chapters, which show topological phases, and energetic square ice in the third and fourth chapter.

What is the relation between brain development and social and cognitive development across childhood, adolescence and adulthood?

SMR can be used to measure the mass of adsorbed protein to nanoparticles with a high precision in the presence of free protein.

The imaging group focuses on bio-imaging, image analysis and visualization.

The ultimate aim of the project is to find out whether there are such things as

The rapid advances in imaging technology enable to see inside the body with ever increasing detail.

How and to what extent the historic house (re-)constructs identity through image-making in China.

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This specialisation focuses on two important trends in health care: early diagnosis and developing the most targeted patient-specific treatment possible with the shortest possible recovery time and minimal side effects.

To study how planetary systems come into existence we study much younger systems still in formation.

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

On the basis of the characteristic aspects of a picture, certain computers can tell us what the picture is showing. They can learn this in the same way that young children are able to learn to recognize images. Further improving these techniques opens the way to a whole range of new applications. Biology…

Obtaining imaging data is nowadays only the start of your project. Once the data has been acquired there are many things that still need to be done.

Light-Harvesting Complex II (LHCII) is responsible for light absorption and excitation energy transfer in plants and photosynthetic algae, while in high light it undergoes conformational changes by which it quenches excitations to prevent photodamage.

Protein–protein complexes are formed via transient states called encounter complexes that greatly influence the formation of the stereospecific complex.

Multi-channel sound and video installation of the on-going project: Decomposing Landscape (2014 -).

In this project we develop algorithms to automatically detect a particular type of archaeological sites in satellite images of the Alps.

This thesis consists of two subjects, that are both a consequence of radiation pressure.

Biodiversity enables ecosystems to thrive through the synergy of functional differences among organisms. While human well-being strongly depends on biodiversity-driven ecosystem services, human actions are also at the root of current unprecedented biodiversity declines.

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This page is under construction.

This thesis focuses on the study of transient and variable radio sources in the universe.

In this research group, led by Dr. Joost Beltman, the aim is to employ mathematical and computational dynamical modelling approaches in order to quantitatively and mechanistically understand the dynamical behaviour and regulation of intracellular networks of genes, proteins and metabolites as well as…

Vera Meester has won the annual Physics Image Award 2016, with her photo of 'smiling' colloids. The Volkskrant published the picture as Image of the Week.

This thesis describes our search to identify and understand possible regulatory mechanisms of integrin α6β4 in cell-matrix adhesion and intracelular signaling.

One of the ways of understanding another culture better is to examine what people experience when they read a text, or look at an image. Leiden experts have a lot of knowledge in this field, for example on culture in ancient Japan.

Metal-containing molecules combine geometrical features and a reactivity that are inherently different from that of organic molecules. My research focuses on light-activatable metal-based anticancer drugs and metal-functionalized liposomes. Light is a very selective way to activate photosensitive drugs…

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

By growing in a soil plants change the biotic and abiotic properties of the soil in which they grow.

This thesis describes the development and validation of new high-contrast imaging techniques, with the ultimate goal of enabling the next generation of instruments for ELT-class telescopes to directly image Earth-like extra-solar planets orbiting around nearby stars.

The challenge of achieving fast quantification in metabolomics is the presence of severe matrix effects during the MS analysis of complex samples.

PhD defence

Promotor: Prof.dr. P. Stevenhagen, Co-Promotor: Dr. J.H. Evertse

Shape and biological function are tightly connected. Physical descriptions are used to connect the shape of a biological system with its function.

Promotores: J.A.van Veen, P.L.G.Klinkhamer. Co-promotor: E.E.Kuramae

Promotor: S.J. Edixhoven, Co-promotor: K.J. Batenburg

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

Understanding the formation and evolution of planetary systems is one of the most fundamental challenges in astronomy. To directly image and study young exoplanets and the circumstellar disks they form from, dedicated high-contrast imaging instruments are built.