Promotor: G.P. van Wezel, Co-promotor: D. Claessen

Promotores: H. Schiessel, G.T. Barkema

During embryonic growth, cells proliferate, differentiate, and collectively migrate to form different tissues at the right position and time in the body.

Synthetic hydrogels that mimic the natural extracellular matrix in the biophysical and biochemical cues it provides to cells are in high demand, however the cell phenotypes as they are observed in vivo in numerous cases have yet to be attained.

Chemist Roxanne Kieltyka has received an ERC Starting Grant of 2 million euros. In her lab, she creates gels that mimic the instructive material that supports cells in our body. With the grant, she aims to make these gels stiff and tough, and to create a bio-printed miniature heart ventricle.

The recently introduced nature-originated deep eutectic solvents, so-called natural deep eutectic solvents (NADES) are considered as truly green solvents, which composed of natural ingredients found abundantly in organisms.

In this thesis, we aim to shed light on the diverse and often opposing roles of integrin α3β1 in cancer.

Promotor: Prof.dr. M. Danhof, Co-promotor: E.C.M. de Lange

Source: Eur J Med Chem, Volume 101, pp. 681-91 (2015)

A novel mathematical model describes spatial-temporal drug distribution within one or more brain units, which are cubic representations of a piece of brain tissue with brain capillaries at the edges.

Cell adhesion signaling

X-Ray Diffraction (XRD), Nuclear Magnetic Resonance (NMR) and Cryo-electron microscopy (Cryo-EM) are the three main methods for solving structures of macromolecules.

PhD Defence

How does the extracellular matrix coordinate endothelial cell behavior during angiogenesis, and how do metabolic waste-products and matrix-degrading enzymes produced by the tumour modify the extracellular matrix so as the change the cellular coordination?

PhD Defence

Promotores: Prof.dr. C.A.M.J.J. van den Hondel, Prof.dr. V. Meyer (Technische Universität Berlin)

Wen Yang is our Institute of Biology Leiden's nominee for the C.J. Kok Jury Award 2020.

Promoter: J.G.E.M.Fraaije, Co-promotor: A. Kros

Develop EPR instrumentation and methodology to investigate intrinsically disordered proteins (IDPs).

Promotores: Prof.dr. G.W. Canters, Prof.dr. T.J. Aartsma

We focus on a better understanding of the mechanisms of cancer drug resistance and metastasis.

PhD Defence

PhD Defence

PhD Defence

Promotor: B. vd Water, T. Schmidt, Co-Promotor: E.H.J. Danen

Promotor: Roeland M.H. Merks

Promotor: Prof.dr. H.P. Spaink Co-promotor: Dr. B.E. Snaar

A new research line is the development of liquid biopsy fingerprints to predict early Alzheimer’s disease (AD) stage in human in readily accessible body fluids in human (in collaboration with: Dr. Geert-Jan Groeneveld, CHDR; Prof. Elga de Vries, Free University Medical Center; and others).

Promotor: Prof.dr. J. den Hertog

Promotor: Prof.dr. J.A. Bouwstra, Co-promotor: Dr. A. El Ghalbzouri

Promotor: Prof.dr. G.P. van Wezel, Co-Promotor: E. Vijgenboom

Acidobacteria is a widely distributed phylum but their functional roles in ecosystem processes are still largely elusive.

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Lecture

How can Staphylococcus aureus bacteria subvert the host immune system?

There is an urgent need for more physiologically relevant cell culture methods to guide compound selection in pre-clinical stages of the drug development pipeline.

Source: Biosens Bioelectron, Volume 74, pp. 233-42 (2015)

Discovery and development of Central Nervous System (CNS) drugs is hampered by high attrition rates.

In this research group, headed by Prof. Erik Danen, the aim is to unravel cellular signaling mechanisms in normal and diseased cells, with a long-standing interest in cell adhesion signaling. In complex multicellular organisms such as ourselves, a division of labor emerges where different tissues and…

The function of TLRs in innate immunity has aroused worldwide attention soon after its discovery. Because of the broad functions of TLR2 in innate immunity, the drive for the development of TLR2-targeted vaccines or therapeutic treatments has accelerated in the last decades.

The research is aimed at development of an efficient gene targeting method that allows controlled integration of DNA at a preselected site in the Trichoderma genome.

The ambition of the Analytical BioSciences and Metabolomics group led by Thomas Hankemeier is to develop innovative analytical strategies for metabolomics-driven health monitoring and systems biology studies. Understanding the intricate balance between health, disease and adaptation to challenges relies…

The lack of success of new CNS drugs in clinical development is in part due to the complexity of the CNS, unexpected side effects, difficulties for drugs to penetrate the brain, but also by the lack of biomarkers.

Source: Mol Psychiatry (2015)

This research group is interested in the physics of living cells, especially their cytoskeleton dynamics under defined external stimuli.

On Friday October 31st 2014 the fourth annual Jan Reedijk LIC Symposium will be held. The main lectures of the day will be

The group of Dr. Roxanne Kieltyka designs and synthesizes molecules that self-assemble into polymeric materials using specific non-covalent interactions. These substrates can be used for numerous applications in medicine ranging from disease detection to cell delivery depending on the (bio)molecular…

The discovery of new medicines is a tedious and lengthy process. On average, over 10,000 molecules need to be studied for one to become a drug and reach the patient. Part of that process are the very costly clinical trials in humans, and candidate drugs often fail due to side effects or lack of efficacy.…