Science

Atoms and molecules are the basic units of matter. If we keep dividing a bar of gold or a glass of water into smaller parts, at the end we are left with a single gold atom or a water molecule.

Before the large scale use of renewable energy sources can be implemented in our society, the storage of electrical energy needs to be tackled. Storage the energy as hydrogen via the reduction of protons is a good option.

Can drug screening for tuberculosis treatment be made more efficient?

The research described in this thesis has, using the zebrafish as a model system, shed new light on the intricate relationship between TB and DM2, in particular on the role of leptin, SHP-1 and glucocorticoids.

The zebrafish is a promising vertebrate model organism in early drug discovery and development.

Science, Leiden Institute of Physics (LION)

Science, Leiden Institute of Physics (LION)

Humanities, Centre for Linguistics

Metal complexes and 2D materials like graphene were combined to produce structures that can function as sensors.

Cell-based medicinal products (CBMPs) show great promise when it comes to the treatment of genetic disorders. However, there is limited knowledge about CBMP stability during their production, storage, and administration to patients. The main focus of my research is the characterization of CBMPs using…

We have examined sequences from the ligand-binding domain of the nicotinic acetyl choline receptor (nAChR) in 148 vertebrate species. We are in interested in this receptor because the α-neurotoxins of many venomous snakes binds to this receptor in its location at the neuromuscular junction in all ve…

Fascinated by science since high school, Alireza Mashaghi Tabari is driven to explore new ways of thinking in medicine. With a strong academic network, he educates students and gives public lectures. For his research at LACDR, he won the C.J. Kok Public Award 2018, making him the Faculty of Science's…

Promotor: Prof.dr. E.F. Smets, Co-promotor: T.R. van Andel

The clinical potential of applying synthetic lethality to cancer treatment is famously demonstrated by the BRCA1/PARP1 paradigm: a tumor specific defect in BRCA1 – a component of the DNA double-strand break (DSB) repair pathway homologous recombination (HR) – results in a remarkable sensitivity to PARP1…

This study examines the mutual intelligibility between all 225 pairs of 15 Chinese dialects, in two main branches, i.e., six Mandarin dialects and nine non-Mandarin (Southern) dialects.

Science, Leiden Institute of Chemistry (LIC)

Source: Mediators Inflamm (2014)

We have developed a microfluidic platform for complex 3D organotypic cell cultures (so-called organ-on-a-chip systems) which are suited for integration in 96 or higher well plate format.

Promotor: Prof.dr. E.F. van Dishoeck, Co-Promotor: G.J. Herczeg

The main objective of this thesis was to develop clinically relevant survival models for patients with high-grade soft tissue sarcoma of the extremities, in particular the development and validation of prediction models for use in clinical practice.

This project employs a systematic experimental approach to examine the interaction of these two hitherto independent lines of research (tone sandhi and focus realization) in six dialects of Chinese, which lie on a continuum between dialects with dense tonal distributions and sparser distributions. In…

Promotor: J. A. Bouwstra

The overall objective of this project is to identify novel drug candidates that are capable of slowing down the progression of neurodegeneration in the subset of Parkinson’s disease (PD) patients with overt mitochondrial dysfunction. Multimodal phenotypic characterisation of cohorts of monogenic PD…

This thesis aims at contributing to our understanding of the semantic and prosodic properties of object foci in Greek, employing theoretical and experimental tools.

This dissertation aims at discussing the nature and the linguistic factors assumed responsible for speech intelligibility problems of Sudanese learners of English.

Collecting as much information as possible about administering a new medicine to people can save a lot of money.

Supervisor: P.J.J. Hooykaas Co-Supervisor: R. Offringa

Promotor: Prof.dr. J. den Hertog

The explosive radiation and diversification of the advanced snakes (superfamily Colubroidea) was associated with changes in all aspects of the shared venom system. Morphological changes included the partitioning of the mixed ancestral glands into two discrete glands devoted for production of venom ormucous…

The electrochemical oxygen reduction reaction (ORR) is an essential half-reaction for the utilization of hydrogen as a sustainable fuel, via the conversion of hydrogen to electrons and protons facilitated by the ORR. In the most common fuel cells, the ORR is requires high loadings of non-abundant platinum…

This dissertation provides an account of polar questions in Italian dialects from a typological, theoretical and empirical perspective.

In this research project, we aimed to obtain more insight in the role of mast cells in the immune driven disorders rheumatoid arthritis and atherosclerosis.

The thesis explores how interstellar chemistry evolves as a function of time and changing physical architectures during the formation of stars.

This thesis is an experimental study of the UV irradiation of the interstellar ice analogues, relevant for the different stages of the star and planet formation sequence.

PhD Defence

Indonesia is experiencing various environmental challenges related to its fast economic growth. Therefore, it is necessary to have measurable and applicable indicators to obtain accurate data and information regarding the costs of adverse environmental impacts arising from economic activities to support…

How is inflammation in tuberculosis controlled by interplay between autophagy and inflammasome signalling?

In this dissertation iron-based homogeneous catalysts were synthesized, characterized and investigated for water oxidation activity.

Promotor: G.P. van Wezel, Co-promotor: D. Claessen

This article by Honorata Mazepus and Florian van Leeuwen in the journal Governance: An International Journal of Policy, Administration and Institutions looks at how evaluations of authorities were influenced by four aspects of a governmental response to a hypothetical disaster.

Can the (industrial) herbal extraction process be mathematically described and can this model be used to optimize the extraction in terms of quality and economical parameters?

Source: J Cheminform, Volume 6, Issue 1 (2014)

An investigation into how racial stereotypes were created and used in the European Middle Ages.

Source: Br. J. Pharmacol., Volume 172, Issue 3, pp. 940-55 (2015)

Medicines do not follow the one size fits all principle, because genetic differences can influence their efficiency. That is what research by PhD candidate Julia Hillger shows. She defends her PhD dissertation Take it Personal on Thursday 7 December.

The dissociative chemisorption of methane on metal surfaces is of fundamental and practical interest, being a rate-limiting step in the steam reforming process. The reaction is best modeled with quantum dynamics calculations, but these are currently not guaranteed to produce accurate results because…

The 10th Experimental Archaeology Conference of EXARC took place in Leiden, Netherlands, over three days; 20th to the 22nd April 2017, in Leiden University’s Faculty of Archaeology. A conference report was published on the website of EXARC.