The factors that dynamically sculpt the inter-regional correlation of brain patterns are poorly understood. Here, we test the hypothesis that they are shaped by the catecholaminergic neuromodulators norepinephrine and dopamine.

Promotor: S.M. Verduyn Lunel

The outermost layer of the skin, the stratum corneum (SC), is responsible for the skin barrier function, protecting the body from pathogens, chemicals and other unwanted substances from the external environment. The SC lipid matrix provides the only continuous pathway through the SC and is considered…

The research described in this thesis focused on the preparation of S/N functionalized carbene ligands and their transition metal complexes, and the exploration of their application as electrocatalysts for proton reduction.

My PhD thesis investigates the ecological significance of resistance against drought-induced air bubble formation inside the water conduits of plants (embolism), and the plasticity and functional aspects of stem anatomical traits in woody and herbaceous species.

The skin protects the body from unwanted influences from the environment as well as excessive water loss. The barrier function of the skin is located in the stratum corneum (SC).

During the course of drug discovery translational steps are made.

This study explores regional variation in the use of utterance-final particles by analyzing spoken Taiwan Mandarin data recorded from spontaneous conversations.

Form and Function in Greek Grammar. Linguistic Contributions to the Study of Greek Literature is a new book, written by Albert Rijksbaron. Rijksbaron is internationally known as one of the leading scholars of the Ancient Greek language, whose work has exerted a strong and lasting influence on the scholarly…

The aim of this thesis was to study the link between hearing loss, language skills, and social functioning in deaf and hard of hearing (DHH) children. Sufficient language skills are an essential prerequisite to develop appropriate communication skills, in order to join in conversations with others.…

Promotor: J.M. van Ruitenbeek, Co-Promotor: S.J. van der Molen

Promotor: P.J.J. Hooykaas, Co-Promotores: P.B.F. Ouwerkerk, M. Wang

What are the precise identities, possibilities and current practice examples of the various time frames in music and what bearings do they have individually and in combinations on the speed of the music?

We will study how inoculation of former arable land with soil (including the microbiome, soil fauna and seeds/rhizomes of ground flora) from old forests along with planting targeted tree species mixtures will improve productivity and more rapidly restore forest-adapted communities and ulttimately result…

Streptomyces present a valuable platform for natural product discovery. Lugdunomycin is a novel angucycline-derived polyketide from Streptomyces sp QL37, with unprecedented skeleton and antimicrobial activity.

OBJECTIVES: To determine whether the lipid/protein ratio and the total dry SC mass per surface area are related with the skin barrier function of controls and AE patients.

An important feature of atopic eczema (AE) is a decreased skin barrier function. The stratum corneum (SC) lipids - comprised of ceramides (CERs), free fatty acids (FFAs) and cholesterol - fulfill a predominant role in the skin barrier function.

To argue that people can control the relative contributions of goal-driven and stimulus-driven processes to decision-making and action selection.

The barrier function of the skin is primarily provided by the stratum corneum (SC), the outermost layer of the skin. Skin barrier impairment is thought to be a primary factor in the pathogenesis of atopic eczema (AE).

In this Ph.D. thesis, we characterized two novel upstream regulators of JUB1, HB40, and HB22, in Arabidopsis thaliana. In Chapter 2, we described functions of HB40 in modulating growth and development via the regulation of JUB1 and GA inactivation genes GA2OXs.

This research will focus on the relationship between the musical structure and musical time in the performance of 19th century music.

Promotor: A. Kros, Co-promotor: R.R.C.L. Olsthoorn

The four possible segments A, T, C and G that link together to form DNA molecules, and with their ordering encode genetic information, are not only different in name, but also in their physical and chemical properties.

Promotor: E.F. Smets Co-promotor: J. Geml

Birds sing to be heard, but how do they cope with increasing noise levels? Which species persist in cities and why? And do they thrive or suffer in the urban soundscape?

To what end and how does Plautus constantly underline the Helleni(sti)c provenance of his art? How does this aspect relate the author’s originality?

This study’s main aim is to test whether children’s learning behaviour explains why they do not benefit from a literate environment.

Source: British Journal of Dermatology, Volume 170, Number 6, pp. E18-E19 (2014) ISBN:0007-0963

Martijn Ridderbos, MSc, will be appointed member and Vice-President of the Executive Board of Leiden University with effect from 8 May 2017. He succeeds Willem te Beest, who is retiring.

On 22 May 2017 Dr Carolien Metselaar (54) will be appointed Secretary to the Executive Board / Director-General of the Administration and Central Services Department at Leiden University.

On 7 November 2018, Catherine Harwood defended her thesis 'Navigating Between Principle and Pragmatism: The Roles and Functions of Atrocity-Related United Nations Commissions of Inquiry in the International Legal Order'. The doctoral research was supervised by Prof. dr. L.J. Van den Herik and Prof.…

The Dies Natalis for alumni on 11 February was an online event. Almost 1,000 alumni tuned in to Bastiaan Rijpkema’s interview with Annetje Ottow, who had then been President of Leiden University’s Executive Board for all of three days. Alumni are part of her portfolio on the Executive Board.

Four years ago, the Institute of Security and Global Affairs (ISGA) first started with an executive master’s programme called Cyber Security. The programme proved to be a huge success and has continued to develop. This academic year, Els de Busser was appointed as Educational Director and Chantal de…

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Effects of maternal smoking, premature birth, intra-uterine growth retardation and asphyxia on child development.

Fundamental insights into the working of the adolescent brain help lecturers and parents to teach adolescents to function better. Professor Eveline Crone studies executive functions – such as planning and behaviour – in the adolescent brain.

Source: Journal of Investigative Dermatology, Volume 135, pp. S59-S59 (2015)

The Executive Board of Leiden University has distanced itself from the Minister of Education, Culture and Science’s response to the Van Rijn Committee report. According to the University’s calculations, following the advice would have serious financial consequences for the entire University and would…

Following a period of intensive discussion, the University Council (UR) approved the University Quality Standards Plan on 10 December. The UR endorses the content of the plan in broad terms and is pleased with the extra efforts made by the University.

Professor Wim van den Doel, dean of the Faculty of Humanities at Leiden University, has been appointed member of the Executive Board of the Netherlands Organisation for Scientific Research (NWO) with effect from 1 January 2017.

The group Clinical Neurodevelopmental Studies has expertise in individual differences in child development, in particular the development of psychopathology, ranging from mild to severe neurodevelopmental disorders. Focus is on etiology, developmental course, diagnosis, prevention and treatment of neurodevelopmental…

Which educational and child welfare interventions offer optimal opportunities for positive development to children with severe behavioral and emotional disorders.

A list of relevant links:

On January 14th the executive Master’s programme Cyber Security started for the second time at the HSD Campus

An international partnership of brain researchers from 35 research centres - from the US to China - including the Leiden Institute for Brain and Cognition (LIBC), has collected resting-state functional MRI data from more than 1400 healthy volunteers and put the information online so that it is available…

Are disturbances to the brain, such as Alzheimer's or autism, linked to specific defects in the underlying communication networks in the brain? If this is the case, subtle changes in the networks can act as a marker for brain disturbances. Neuroscientist Serge Rombouts will be investigating this, together…